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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Indian hedgehog

Ihh, X-bhh, X-hh
Top mentioned proteins: Parathyroid Hormone-Related Protein, Shh, Gli, Runx2, CAN
Papers on Ihh
Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters.
New
Ohno et al., Nagoya, Japan. In Biochem Biophys Res Commun, Feb 2016
Moreover, tranilast upregulated mRNA expression of essential signaling molecules involved in endochondral ossification (Pthrp, Ihh, and Axin2).
Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies.
New
Cohn et al., Carbondale, United States. In Proc Natl Acad Sci U S A, Jan 2016
We identify Indian hedgehog (Ihh) as a novel downstream target of AR in external genitalia and show that conditional deletion of Ihh inhibits penile masculinization.
Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.
New
Lanske et al., Boston, United States. In Bone, Dec 2015
One such factor is Ihh, a gene linked to BDA1 and distal symphalangism in humans.
The Hedgehog signalling pathway in bone formation.
Review
New
Yang et al., Chengdu, China. In Int J Oral Sci, Jun 2015
Indian Hedgehog (Ihh) has an essential function in endochondral ossification and induces osteoblast differentiation in the perichondrium.
Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption.
McIntyre et al., Cleveland, United States. In Plos One, 2014
Loss of PTAFR also abolished ethanol-stimulated Sonic (Shh) and Indian hedgehog (Ihh) expression, and abolished transcription and accumulation of Gli1.
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β.
Knight et al., New York City, United States. In Arthritis Res Ther, 2014
METHODS: Isolated articular chondrocytes from the bovine metacarpal-phalangeal joint were stimulated for up to 24 hours with the agonist, recombinant Indian hedgehog (r-Ihh).
Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease.
Review
Wei et al., Providence, United States. In Connect Tissue Res, 2014
The Hedgehog (Hh) family of proteins consists of Indian hedgehog (Ihh), sonic hedgehog (Shh), and desert hedgehog (Dhh).
[Identification of osteogenic signal and the development of artificial bones].
Review
Tei et al., Tokyo, Japan. In Clin Calcium, 2013
During the endochondral ossification, indian hedgehog (Ihh) /parathyroid hormone-related protein (PTHrP) negative-feedback loop regulates the distance between epiphysis and the layer of hypertrophic chondrocytes.
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
Impact
Neel et al., Providence, United States. In Nature, 2013
Chondroid neoplasms arise from these cells and show decreased extracellular signal-regulated kinase (ERK) pathway activation, increased Indian hedgehog (Ihh) and parathyroid hormone-related protein (Pthrp, also known as Pthlh) expression and excessive proliferation.
Small-molecule antagonists of Gli function
Review
Chen et al., Bethesda, United States. In Unknown Journal, 2013
Hh signaling is normally initiated by the binding of Hh ligands (Shh, Ihh, and Dhh) to the 12TM Patched1 (Ptch1) receptor resulting in accumulation and activation of the G protein-coupled receptor-like protein Smoothened (Smo) within the primary cilium.
Indian hedgehog signaling is required for proper formation, maintenance and migration of Xenopus neural crest.
GeneRIF
Aybar et al., San Miguel de Tucumán, Argentina. In Dev Biol, 2012
By a combination of embryological andmolecular approaches the results demonstrated that Indian hedgehog protein signaling drives the migration of neural crest cells by autocrine or paracrine mechanisms.
Hedgehog signaling.
Review
Cheng et al., Hong Kong, Hong Kong. In Vitam Horm, 2011
The hedgehog family consists of sonic hedgehog (Shh), desert hedgehog (Dhh), and Indian hedgehog (Ihh).
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.
Impact
Chan et al., Hong Kong, Hong Kong. In Nature, 2009
It is associated with heterozygous missense mutations in indian hedgehog (IHH).
Hedgehog signaling in development and homeostasis of the gastrointestinal tract.
Review
Impact
van den Brink, Amsterdam, Netherlands. In Physiol Rev, 2007
Three mammalian hedgehog genes, sonic hedgehog (Shh), indian hedgehog (Ihh), and desert hedgehog (Dhh) have been identified.
Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus.
Impact
DeMayo et al., Houston, United States. In Nat Genet, 2006
Indian hedgehog (encoded by Ihh) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone.
Expression profile of Xenopus banded hedgehog, a homolog of mouse Indian hedgehog, is related to the late development of endochondral ossification in Xenopus laevis.
GeneRIF
Yamaguchi et al., Nagasaki, Japan. In Biochem Biophys Res Commun, 2005
Considered collectively, the present study suggests that X-bhh evolutionally acquired the function to induce osteogenesis; however, the expression profile of X-bhh in epiphysis is related to the late development of endochondral ossification in X. laevis.
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Impact
Peppelenbosch et al., Amsterdam, Netherlands. In Nat Genet, 2004
We report that Indian hedgehog (Ihh) is expressed by mature colonocytes and regulates their differentiation in vitro and in vivo.
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