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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Immunoglobulin heavy constant mu

IgM, mu-H
Top mentioned proteins: CAN, IgA, HAD, AGE, Phosphogluconate Dehydrogenase
Papers using IgM antibodies
Anti-citrullinated protein antibodies have a low avidity compared with antibodies against recall antigens
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Trouw Leendert A et al., In Arthritis Research & Therapy, 2010
... incubated at 1:25 dilution at 37°C for 1 hour, bound antibodies were detected using rabbit anti-human IgM (Dako Denmark A/S, Glostrup, Denmark), ...
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.
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Navarro Alfons, In PLoS ONE, 2009
... were treated for 4 h with 10 µg/ml whole antibody (Rituximab (Roche), LT20 (Exbio), anti-IgG antibody, anti-IgM antibody (SouthernBiotech), isotype (SouthernBiotech) ...
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
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Houtman Jon CD., In PLoS ONE, 2008
... Agonistic IgM anti-human CD95 mAb clone 7C11, hamster anti-mouse CD95 mAb clone JO2 and anti-human CD95 mAb clone DX2 were purchased from BD Biosciences (Le Pont de Claix, ...
The investigation of parvovirus B19 infection in patients with haematological disorders by using PCR and ELISA techniques
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Kumar Archana et al., In The Indian Journal of Medical Research, 2006
... B19 virus specific IgM and IgG antibodies in serum samples were determined using quantitative ELISA kits (IBL Hamburg, Germany) ...
Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups
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Brezinschek Hans-Peter et al., In Arthritis Research & Therapy, 2005
... of anti-cyclic-citrullinated peptide (aCCP) (Immunoscan RA; Euro Diagnostica, Malmö, Sweden) and rheumatoid factor (AutostatTMII RF IgM; Hycor Biomedical, Kassel, Germany) ...
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Papers on IgM
Effect of yeast-derived products and distillers dried grains with solubles (DDGS) on antibody-mediated immune response and gene expression of pattern recognition receptors and cytokines in broiler chickens immunized with T-cell dependent antigens.
New
Slominski et al., Winnipeg, Canada. In Poult Sci, Feb 2016
Serum samples were analyzed by hemagglutination test for antibody response to SRBC, and by ELISA for serum IgM and IgG response to BSA.
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.
New
Hörkkö et al., Oulu, Finland. In Immunol Res, Feb 2016
UNASSIGNED: Natural antibodies are predominantly antibodies of the IgM isotype present in the circulation of all vertebrates that have not been previously exposed to exogenous antigens.
Detection of specific immunoglobulin E antibodies toward common airborne allergens, peanut, wheat, and latex in solvent/detergent-treated pooled plasma.
New
Kristoffersen et al., Bergen, Norway. In Transfusion, Feb 2016
STUDY DESIGN AND METHODS: Consecutive batches of S/D-plasma transfused during September 2014 through March 2015 were investigated for IgE, IgG, IgA IgM, C3, C4, haptoglobin, anti-nuclear antibodies (ANAs), and red blood cell (RBC) antibodies.
The effects of increasing dietary levels of amino acid-supplemented soy protein concentrate and constant dietary supplementation of phosphorus on growth, composition and immune responses of juvenile Atlantic salmon (Salmo salar L.).
New
Thompson et al., Stirling, United Kingdom. In Fish Physiol Biochem, Feb 2016
Enhanced plasma haemolytic activity, increased total IgM, and a rise in thrombocytes were demonstrated in SPC50 and SPC65 salmon on Day 97, while increased lysozyme activity was demonstrated for these groups on Days 63, 70 and 97.
Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1.
New
Wahlgren et al., Stockholm, Sweden. In Cell Rep, Feb 2016
Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood malaria and pregnancy-associated malaria.
A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.
Review
New
Ptak et al., Kraków, Poland. In Ann N Y Acad Sci, Dec 2015
sB-1a cells resemble memory B2 cells, as they are stimulated within 1 h of immunization and depend on T helper cytokines-uniquely IL-4 from hepatic iNKT cells-for activation and rapid migration from the peritoneal cavity to the spleen to secrete IgM antibody (Ab) and Ab-derived free light chains (FLCs) by only 1 day after immunization.
Developments in the production of mucosal antibodies in plants.
Review
New
Schiermeyer et al., Aachen, Germany. In Biotechnol Adv, Dec 2015
Plant cells are able to produce high-quality mucosal antibodies as shown by the successful expression of the secretory immunoglobulins A (IgA) and M (IgM) in various antibody formats in different plant species including tobacco and its close relative Nicotiana benthamiana, maize, tomato and Arabidopsis thaliana.
New Insights in the Pathogenesis of Autoimmune Hemolytic Anemia.
Review
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Barcellini, Milano, Italy. In Transfus Med Hemother, Sep 2015
The pathogenic role of autoantibodies depends on their class (the most frequent are IgG and IgM), subclass, thermal amplitude (warm and cold forms),as well as affinity and efficiency in activating complement.
Responsiveness of B cells is regulated by the hinge region of IgD.
New
Impact
Jumaa et al., Ulm, Germany. In Nat Immunol, May 2015
Mature B cells express immunoglobulin M (IgM)- and IgD-isotype B cell antigen receptors, but the importance of IgD for B cell function has been unclear.
Development of Globo-H cancer vaccine.
New
Impact
Wong et al., New York City, United States. In Acc Chem Res, Apr 2015
In addition, a new glycolipid adjuvant was designed to target the CD1d receptor on dendritic cells and B cells for presentation to and activation of T cells to modulate the immune response and induce a class switch from IgM to IgG, thereby overcoming the common problem of carbohydrate-based vaccines that often induce mainly IgM antibodies.
The active intrathecal B-cell response in LGI1-antibody encephalitis.
New
Impact
von Büdingen et al., San Francisco, United States. In Lancet, Mar 2015
Bioinformatics clustering of related IgM-VH or IgG-VH transcripts was used to determine whether active B-cell diversification could be observed, and whether intrathecal B-cell repertoires, if present, were related to peripheral B cells.
Immunosuppression - tough ally in torrid time.
Review
Fol et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2014
This is related to the variable levels of deficiency for each antibody class (IgG, IgM, IgA) and a decrease in the number and function of immune cells, mainly T cells which results in the inhibition of cytokine production, signaling transduction and clonal expansion.
Antibody Isotype Switching in Vertebrates.
Review
Zarrin et al., San Francisco, United States. In Results Probl Cell Differ, 2014
Different immunoglobulin (Ig) classes include IgM, IgD, IgG, IgE, and IgA, which exist as surface-bound and secreted forms.
ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism.
Impact
Grassi et al., Bellinzona, Switzerland. In Immunity, 2014
The ensuing depletion of mucosal bacteria resulted in reduced systemic translocation of microbial components, lowering B1 cell stimulation and serum IgM concentrations.
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
Impact
Fillatreau et al., Berlin, Germany. In Nature, 2014
During Salmonella infection, IL-35- and IL-10-producing B cells corresponded to two largely distinct sets of surface-IgM(+)CD138(hi)TACI(+)CXCR4(+)CD1d(int)Tim1(int) plasma cells expressing the transcription factor Blimp1 (also known as Prdm1).
T helper cell- and CD40-dependent germline IgM prevents chronic virus-induced demyelinating disease.
GeneRIF
Ludewig et al., Sankt Gallen, Switzerland. In Proc Natl Acad Sci U S A, 2012
Coronavirus-induced demyelinating CNS disease can be efficiently prevented by a long-lasting germline-encoded IgM response.
Core fucosylation of μ heavy chains regulates assembly and intracellular signaling of precursor B cell receptors.
GeneRIF
Taniguchi et al., Dalian, China. In J Biol Chem, 2012
Core fucosylation of mu heavy chains regulates assembly and intracellular signaling of precursor B cell receptors.
Excessive amounts of mu heavy chain block B-cell development.
GeneRIF
Dunnick et al., Ann Arbor, United States. In Int Immunol, 2011
deficiencies in B-cell development increase with increased transgene copy number
A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.
GeneRIF
Winkler et al., Erlangen, Germany. In Embo J, 2011
The critical importance of pre-BCR and BCR receptor levels for the normal development of B-lymphocyte subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire.
Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina.
GeneRIF
Kolls et al., Pittsburgh, United States. In J Exp Med, 2011
Data suggest a novel role for the IgM isotype in shaping the earliest steps in recognition and clearance of fungus.
More papers using IgM antibodies
Alterations of N-glycan branching and expression of sialic acid on amniotic fluid alpha-1-acid glycoprotein derived from second and third trimesters of normal and prolonged pregnancies.
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Egles Christophe, In PLoS ONE, 2005
rat anti-mouse IgM monoclonal and R-PE-conjugated rat anti-mouse IgM monoclonal antibodies were purchased from BD Biosciences (Franklin Lakes, NJ, USA) ...
Tularemia in Denmark: identification of a Francisella tularensis subsp. holarctica strain by real-time PCR and high-resolution typing by multiple-locus variable-number tandem repeat analysis
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Wakasa Haruki et al., In Virchows Archiv, 2004
... Kumamoto, Japan), Langerin (Novocastra Laboratories Ltd.), S-100 (Dako), D2-40 (Nichirei Corp.), Fascin, HLA-DR, IgG, IgA, IgM, κ, λ (all Dako), and anti- ...
Human embryonic stem cell lines with genetic disorders
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Lavon Neta et al., In In Vitro Cellular & Developmental Biology. Animal, 2004
... As secondary antibodies, we used goat anti-mouse IgG PE, goat anti-mouse IgM FITC, and donkey anti-rabbit FITC (Santa Cruz Biotechnology Inc) ...
Two distinct cytoplasmic regions of the β2 integrin chain regulate RhoA function during phagocytosis
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Caron Emmanuelle et al., In The Journal of Cell Biology, 2004
... RBCs were purchased from TCS Biosciences, Ltd., anti–sheep erythrocyte IgM antibodies were purchased from Cedarlane Laboratories, Ltd., and gelatin ...
Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies.
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Câmara Niels Olsen Saraiva, In PLoS ONE, 2003
... For immunofluorescence, 3 µm cryostat sections sections were stained with polyclonal FITC-conjugated antibodies to IgG, IgA, IgM, C3, kappa, lambda, fibrinogen and albuminn (Dako).
Identification of a novel isoform of Cdk9.
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Zeleznik-Le Nancy, In PLoS Biology, 2002
... The monoclonal anti-MLL IgM (HRX107) antibody [33] is available from Santa Cruz Biotechnology.
Chemokine Receptor CCR9 Contributes to the Localization of Plasma Cells to the Small Intestine
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Förster Reinhold et al., In The Journal of Experimental Medicine, 2002
... Cells were stained using the following antibodies: anti-CD3-PE (Caltag), IgA-biotin, CD19-biotin (Biosource International), CD138-PE, B220-PerCP, IgM, and IgD (BD Biosciences).
Affective style and in vivo immune response: neurobehavioral mechanisms.
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Akbarian Schahram, In PLoS ONE, 2002
... using Elisa plates coated with TNP-OVA, whereupon the bound IgM were measured using the rat IgM detection kit of Bethyl laboratories (cat nr.E110-100) as ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
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Ploplis Victoria A et al., In Vascular Cell, 2002
Where required the secondary antibodies were HRP-conjugated goat anti-rabbit IgG (Cell Signaling Technology), goat anti-mouse IgM, and goat anti-armenian hamster (Santa Cruz Biotechnology).
Melanoma cell attachment, invasion, and integrin expression is upregulated by tumour necrosis factor alpha and suppressed by alpha melanocyte stimulating hormone
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Mac Neil S et al., In British Journal of Cancer, 2001
... Murine anti-HMB45 IgM was from Dako, Carpintera, USA ...
The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting
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Schäkel Knut et al., In The Journal of Experimental Medicine, 2001
... CD36, CD64, CD86, HLA-DR, HLA-DP (all from BD Biosciences), E-cadherin (Santa Cruz Biotechnology, Inc.), and IgM nonbinding control (BD Biosciences), CD83 (Serotec), control mAb ...
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
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Ron David et al., In The Journal of Cell Biology, 2001
... to the vendor’s specification: anti-PDI (Stressgen), anti-KDEL (Stressgen), anti–β-actin (Sigma-Aldrich), anti–bovine insulin (Millipore), and anti–mouse IgM (Rockland).
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Pesce Maurizio, In PLoS ONE, 2000
... from Cayman Chemical (Ann Arbor, Michigan, USA); the monoclonal phycoerythrin (PE)-anti-hCD36 and isotype control PE-mouse IgM from BD Biosciences (Franklin Lakes, NJ, USA); ...
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites
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Simons Mikael et al., In The Journal of Cell Biology, 1999
... Signaling), clathrin heavy chain (monoclonal IgG; BD Transduction Laboratories), GFP (Synaptic Systems GmbH), caveolin-1 (monoclonal IgM; BD Biosciences), and Lamp-1 (CD107a, rat ...
The B Cell Antigen Receptor Controls Integrin Activity through Btk and PLCγ2
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Pals Steven T. et al., In The Journal of Experimental Medicine, 1999
... Mouse anti-T7-tag (Novagen); anti-CD45R(B220) and anti-mouse IgM microbeads (Miltenyi Biotec); mouse anti-human IgM (MH15; ...
Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response
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Jenkins Marc K. et al., In The Journal of Experimental Medicine, 1999
... 3-83 IgM/D transgenic B10.D2nSn/J mice ( ...
Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis.
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Bonini Marcelo G., In PLoS ONE, 1999
... CD11b-PE, and isotype control IgG1-PE were obtained from Serotec (Oxford, UK), and isotype control mouse IgM-PE from Dako (Glostrup, Denmark).
An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene.
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Haber James E., In PLoS ONE, 1998
... cells were stained with anti-chicken IgM-RPE (Southern Biotechnology Associates, Birmingham, AL), and analyzed on a FACScan with CellQuest software (BD Biosciences).
Interaction of SLP adaptors with the SH2 domain of Tec family kinases
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Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 1998
... surface expression of BCR or CD16 was analyzed by FACScan™ (Becton Dickinson) using FITC-conjugated anti–chicken IgM Ab (Bethyl) or FITC-conjugated anti–human CD16 ...
Auto-antibodies to T-lineage cells in aged mice
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Taub Dennis D. et al., In International Journal of Medical Sciences, 1997
... The nitrocellulose filters were then probed using HRP-conjugated specific antibodies to the immunoglobulin heavy chain M (IgM) and IgG obtained from Abcam (Cambridge, MA) ...
Silencing of B Cell Receptor Signals in Human Naive B Cells
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Müschen Markus et al., In The Journal of Experimental Medicine, 1996
... ) using a rat anti-CD77 IgM antibody (BD Biosciences) together with a mouse anti–rat ...
A mouse model of Borrelia meningitis after intradermal injection.
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Rotzschke Olaf, In PLoS ONE, 1996
... The polyclonal goat anti-IgM F(ab')2 was obtained from ICN/MP Biomedicals, (Irvine, CA, USA), and ...
Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin
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Davoust J. et al., In The Journal of Experimental Medicine, 1995
... Anti-CCR7 (clone 2H4 mouse IgM) was obtained from Becton Dickinson.
Integrin transmembrane signaling and cytoskeletal control
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Holly Jeff M. P. et al., In Frontiers in Endocrinology, 1994
... A negative control mouse IgM was bought from Dako, Cambridgeshire, UK ...
Enumeration and characterisation of DJHstructures in mouse fetal liver
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Ehlich Andreas et al., In The Journal of Experimental Medicine, 1991
... ) or antibody CD11B (anti–Mac-1; Miltenyi Biotec), and in addition rat anti–mouse IgM (Miltenyi Biotec) antibodies for the experiment with subsequent κ protein staining, coupled to magnetic beads (Miltenyi Biotec).
Proteoglycans as modulators of growth factor activities
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Pals Steven T. et al., In The Journal of Experimental Medicine, 1990
(IgG1) (R&D Systems, Abingdon, UK); anti-CD3, OKT-3 (IgG2a) (ATCC); anti-DRC-1, R4/23 (IgM) (DAKO, Glostrup, Denmark); anti-CD19, HD37 ...
Prognosis of aggressive lymphomas: a study of five prognostic models with patients included in the LNH-84 regimen
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Ahn Hee-Bae et al., In Korean Journal of Ophthalmology : KJO, 1988
... Immunohistochemical testing was performed using the peroxidase-antiperoxiadase (PAP) technique with antibodies against IgG, IgM, CD3 (1:50, Dako Corporation, Santa Barbara, CA, ...
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
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van Noesel Carel J.M. et al., In The Journal of Experimental Medicine, 1988
... Monoclonal antibodies used: IgM, κ- and λ-light chains (Becton Dickinson), IgG, IgA, CD20 (L26; ...
Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis
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Wienands Jürgen et al., In The EMBO Journal, 1987
... DT40 B cells by incubation of the cells with 2 μg/ml mouse anti-chicken IgM (M4, Bethyl) for various time points ...
Immunohistochemical localization of the epithelial marker mam-6 in invasive malignancies and highly dysplastic adenomas of the large-intestine
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King Michael R. et al., In Frontiers in Oncology, 1986
... control, purified mouse anti-human CD15s (clone CSLEX), APC rat anti-mouse IgM, and FITC goat anti-mouse IgG/IgM were all purchased from BD Biosciences (San Jose, CA, USA) ...
The human gut contains a novel population of B lymphocytes which resemble marginal zone cells
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Goodnow Christopher C. et al., In The Journal of Experimental Medicine, 1984
... IgM-transgenic mice were produced previously ...
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