Identification of gene expression signature for cigarette smoke exposure response-from man to mouse.
Neuchâtel, Switzerland. In Hum Exp Toxicol, Dec 2015
The signature consisted of LRRN3, SASH1, PALLD, RGL1, TNFRSF17, CDKN1C, IGJ, RRM2, ID3, SERPING1, and FUCA1.
Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.
Scottsdale, United States. In Leukemia, 2014
Rearrangements reposition MYC near a limited number of genes associated with conventional enhancers, but mostly with super-enhancers (e.g., IGH, IGL, IGK, NSMCE2, TXNDC5, FAM46C, FOXO3, IGJ, PRDM1).
Nasal mucus proteomic changes reflect altered immune responses and epithelial permeability in patients with allergic rhinitis.
Graz, Austria. In J Allergy Clin Immunol, 2014
Five proteins were found to be significantly upregulated in patients with allergic rhinitis (apolipoprotein A-2 [APOA2], 9.7-fold; α2-macroglobulin [A2M], 4.5-fold; apolipoprotein A-1 [APOA1], 3.2-fold; α1-antitrypsin [SERPINA1], 2.5-fold; and complement C3 [C3], 2.3-fold) and 5 were found to be downregulated (antileukoproteinase [SLPI], 0.6-fold; WAP 4-disulfide core domain protein [WFDC2], 0.5-fold; haptoglobin [HP], 0.7-fold; IgJ chain [IGJ], 0.7-fold; and Ig hc V-III region BRO, 0.8-fold) compared with levels seen in healthy control subjects.
The plasma cell signature in autoimmune disease.
Gaithersburg, United States. In Arthritis Rheumatol, 2014
Whole-genome microarray analysis of sorted cellular fractions identified a panel of genes, IGHA1, IGJ, IGKC, IGKV4-1, and TNFRSF17, expressed predominantly in PCs.
[Development of polycomponent metabolite probiotic].
In Zh Mikrobiol Epidemiol Immunobiol, 2013
CONCLUSION: Polycomponent metabolite probiotic based on CF supernatant of Lactobacillus helveticus NKJC, Lactobacillus helveticus JCH and Lactobacillus casei KAA strains completely retains bactericidal and fungicidal activity of the native culture of the consortium of strains and at the same time lacks disadvantages of compositions containing live microorganisms.
Theoretical investigations of α,α,α-trifluoro-3, -p and o-nitrotoluene by means of density functional theory.
Bolu, Turkey. In Spectrochim Acta A Mol Biomol Spectrosc, 2012
This study reports the optimized molecular structures, vibrational frequencies including Infrared intensities and Raman activities, corresponding vibrational assignments, (1)H and (13)C NMR chemical shifts, the magnitudes of the JCH and JCC coupling constants, Ultraviolet-visible (UV-vis) spectra, thermodynamic properties and atomic charges of the title compounds, α,α,α-trifluoro-3, -p and o-nitrotoluene, in the ground state by means of the density functional theory (DFT) with the standard B3LYP/6-311++G(d,p) method and basis set combination for the first time.