The multiple facets of FcRn in immunity.
Amsterdam, Netherlands. In Immunol Rev, Nov 2015
Herein, the function of FcRn will be reviewed, with emphasis on its recently documented significance for IgG polymorphisms affecting the half-life and biodistribution of IgG3, on its role in phagocyte biology, and the subsequent role for the presentation of antigens to lymphocytes.
IgG1 protects against renal disease in a mouse model of cryoglobulinaemia.
Cincinnati, United States. In Nature, Feb 2015
IgG3, which self-associates to form large immune complexes, accounts for more than 97% of the mouse Ig in this cryoglobulin; furthermore, glomerular disease develops when mice are injected with IgG3 anti-trinitrophenyl (TNP) monoclonal antibody followed by a TNP-labelled protein.