IGF-I in major depression and antidepressant treatment response.
München, Germany. In Eur Neuropsychopharmacol, Jun 2015
A genetic association analysis of polymorphisms in 10 genes contributing to the IGF-I system (IGF1, IGF1R, IGFBP1 to IGFBP7, and IGFBPL1) in the currently largest genetic databases for major depression (Psychiatric Genomics Consortium) revealed nominal associations with susceptibility for depression and treatment response, although results did not remain significant after multiple testing correction.
Determinants of growth in diabetic pubertal subjects.
Sweden. In Diabetes Care, 1997
Despite decreased IGF-I levels, target final height was attained, probably because of adequate insulin compensation leading to normal IGFBP-l, thus adequate bioavailability of IGF-I.
Circulating binding proteins for the insulinlike growth factors.
Australia. In Trends Endocrinol Metab, 1993
IGFBP-l, which is metabolically regulated by insulin and carbohydrates, may act as a counterregulator in blood glucose regulation and could also be important in targeting IGF delivery from the circulation to the tissues, while recent studies of IGFBP-2 physiology suggest that this protein may function as an additional IGF carrier when IGFBP-3 levels are inadequate.