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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Insulin-like growth factor binding protein 6

IGFBP-6, Insulin-Like Growth Factor Binding Protein 6
high-affinity IGF binding ptotein with substantially greater affinity for insulin-like growth factor-II (IGF-II) than IGF-I [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Insulin-Like Growth Factor Binding Protein 3, IGFBP-2
Papers on IGFBP-6
The transcribed-ultraconserved regions in prostate and gastric cancer: DNA hypermethylation and microRNA-associated regulation.
New
Yasui et al., Hiroshima, Japan. In Oncogene, Jan 2016
Furthermore, Uc.416+A was associated with cell growth through the regulation of IGFBP6 (insulin-like growth factor-binding protein 6) in GC.
Insulin-like growth factor binding proteins 4-6.
Review
New
Bach, Australia. In Best Pract Res Clin Endocrinol Metab, Oct 2015
IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances.
IRE1 inhibition affects the expression of insulin-like growth factor binding protein genes and modifies its sensitivity to glucose deprivation in U87 glioma cells.
New
Minchenko et al., In Endocr Regul, Oct 2015
OBJECTIVE: The aim of the present study was to investigate the effect of inhibition of endoplasmic reticulum stress signaling mediated by IRE1/ERN1 (inositol-requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) on the expression of genes encoding different groups of insulin-like growth binding proteins (IGFBP6 and IGFBP7) and CCN family (IGFBP8/CTGF/CCN2, IGFBP9/NOV/CCN3, IGFBP10/CYR61/CCN1, WISP1/CCN4, and WISP2/CCN5) and its sensitivity to glucose deprivation in U87 glioma cells.
Platelet Poor Plasma and Platelet Rich Plasma Stimulate Bone Lineage Differentiation in Periodontal Ligament Stem Cells.
New
Smith et al., Santiago, Chile. In J Periodontol, Oct 2015
RESULTS: Albeit at different concentrations, both fractions had a similar profile of growth factors being the most representative Platelet derived growth factors isoforms (PDGF-AA, PDGF-BB, PDGF-AB), Insulin-like Growth Factor Binding Proteins 2 and 6 (IGFBP-2, IGFBP-6).
IGF-IR: a new prognostic biomarker for human glioblastoma.
New
Salmon et al., Brussels, Belgium. In Br J Cancer, Oct 2015
The insulin-like growth factor (IGF) system is a complex network that includes ligands (IGFI and IGFII), receptors (IGF-IR and IGF-IIR) and high-affinity binding proteins (IGFBP-1 to IGFBP-6).
Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals.
New
Paramithiotis et al., United States. In Ebiomedicine, Sep 2015
Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV(-) individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV(+) individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC = 0.96 for HIV(-) TB, 0.95 for HIV(+) TB).
Linkage analysis of SNPs in IGFBP-6 and its relation with the body sizes of pig.
Hao et al., Changchun, China. In Genet Mol Res, 2014
Insulin-like growth factor binding protein-6 (IGFBP-6) is a member of the IGFBP family, which is known to be a key factor in regulating the effect of insulin-like growth factor-2 (IGF-2) on the animal growth and development.
Molecular characterization and expression patterns of insulin-like growth factor-binding protein genes in postnatal Nanjiang brown goats.
Zhang et al., China. In Genet Mol Res, 2014
Expression levels of IGFBP-1, -2 and -5 mRNA were higher in liver than in heart and LD muscle (P < 0.01), while IGFBP-6 expression was highest in LD muscle, and IGFBP-3 and -4 were predominantly expressed in LD muscle and liver.
Metabolic and endocrine profiles and hepatic gene expression of Holstein cows fed total mixed ration or pasture with different grazing strategies during early lactation.
Carriquiry et al., Montevideo, Uruguay. In Acta Vet Scand, 2014
However, only hepatic IGFBP6 and LEPRb mRNA were greater in G2 than G0 and G1 cows, respectively.
Insulin-like growth factor-binding protein-6 and cancer.
Review
Yang et al., Melbourne, Australia. In Clin Sci (lond), 2013
IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because of its marked binding preference for IGF-II over IGF-I.
IGF binding protein-6 expression in vascular endothelial cells is induced by hypoxia and plays a negative role in tumor angiogenesis.
GeneRIF
Duan et al., Qingdao, China. In Int J Cancer, 2012
These results suggest that the expression of IGFBP-6 in vascular endothelial cells is up-regulated by hypoxia and IGFBP-6 inhibits angiogenesis in vitro and in vivo
Insulin-like growth factor binding protein-6 interacts with the thyroid hormone receptor α1 and modulates the thyroid hormone-response in osteoblastic differentiation.
GeneRIF
Huang et al., Beijing, China. In Mol Cell Biochem, 2012
IGFBP-6 acts as a inhibitory mediator of thyroid hormone effects in osteoblast differentiation
Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures.
GeneRIF
Kurosaka et al., Kōbe, Japan. In J Orthop Res, 2011
IGFs/IGFBPs may have important roles not only in fracture healing but also in nonunion formation.
Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts.
GeneRIF
Jansen-Duerr et al., Innsbruck, Austria. In Mech Ageing Dev, 2011
When IGFBP-6 gene expression was downregulated, cell proliferation was inhibited and apoptotic cell death was increased.
Cyclopamine blocked the growth of colorectal cancer SW116 cells by modulating some target genes of Gli1 in vitro.
GeneRIF
Guo et al., Shanghai, China. In Hepatogastroenterology, 2011
Hh pathway is aberrant activation in colorectal carcinoma cell line. Its inhibitor may be effectual agent for colorectal cancer chemoprevention. Gli1 maintained cell survival by binding promoter regions and facilitating transcription of IGFBP6 and Bcl-2.
IGFBP-2 at the interface of growth and metabolism--implications for childhood obesity.
Review
Werther et al., Melbourne, Australia. In Pediatr Endocrinol Rev, 2011
Six well characterised binding proteins (IGFBP-1 to IGFBP-6) act as general carriers of IGF-I, but they also modulate IGF-I bioavailability and activity in a tissue-specific, and developmentally appropriate, manner.
IGF system in cancer: from bench to clinic.
Review
Saif et al., United States. In Anticancer Drugs, 2011
The IGF system is a complex system comprising two growth factors (IGF-I and IGF-II), cell surface receptors (IGF-IR and IGF-IIR), six specific high-affinity binding proteins (IGFBP-1 to IGFBP-6), IGFBP proteases, and several other IGFBP-interacting molecules that regulate and propagate IGF actions in several tissues.
The role of IGF-1R in pediatric malignancies.
Review
Helman et al., Bethesda, United States. In Oncologist, 2009
The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6).
Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes.
Impact
Eng et al., Columbus, United States. In J Clin Oncol, 2004
PTCs showed overexpression of CITED1, claudin-10 (CLDN10), and insulin-like growth factor binding protein 6 (IGFBP6) but showed no change in expression of caveolin-1 (CAV1) or -2 (CAV2); conversely, FTCs did not express CLDN10 and had decreased expression of IGFBP6 and/or CAV1 and CAV2.
Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis.
Impact
De Keyser et al., Groningen, Netherlands. In Lancet, 2003
Compared with controls, immunoreactivity in the spinal motor neurons of patients with amyotrophic lateral sclerosis was 64% higher for IGFBP2, 46% higher for IGFBP5, and 33% higher for IGFBP6, with upregulation of IGF-I receptors.
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