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Insulin-like growth factor binding protein 4

IGFBP-4, Insulin-Like Growth Factor Binding Protein 4
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor Binding Protein 3, IGFBP-2, Insulin-Like Growth Factor II
Papers on IGFBP-4
Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species.
New
Hoeflich et al., Germany. In Growth Horm Igf Res, Feb 2016
Holstein Friesian dairy cows had higher levels of IGFBP-4 (P<0.05), if compared to conventional crossbreeds of beef cattle.
Transcriptome analysis reveals the molecular mechanisms underlying growth superiority in a novel grouper hybrid (Epinephelus fuscogutatus♀ × E. lanceolatus♂).
New
Zhang et al., Guangzhou, China. In Bmc Genet, Dec 2015
Further analysis showed the expressions of GnRH1and GnRH3 in the brain, and GH/IGF axis related genes such as IGF-1, IGF-2b, IGFBP-1, IGFBP-2, IGFBP-4 and IGFBP-5a in the liver of the hybrid F1 were significantly up-regulated, which is in accordance with the growth superiority of hybrid grouper.
Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone.
New
Conover et al., Rochester, United States. In Bone, Dec 2015
Pregnancy-associated plasma protein-A (PAPP-A) is a metalloprotease expressed by osteoblasts in vitro that has been shown to enhance local IGF action through cleavage of inhibitory IGFBP-4.
Pregnancy-associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels.
New
Andersen et al., Copenhagen, Denmark. In Fertil Steril, Nov 2015
INTERVENTION(S): ELISA measurement of steroids, PAPP-A, and AMH, immunohistochemistry of PAPP-A, AMH, and aromatase on follicles of different diameter, and proteolytic activity of PAPP-A toward insulin-like growth factor (IGF)-binding protein 4 (IGFBP-4).
PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma.
New
Frystyk et al., Århus, Denmark. In Oncotarget, Nov 2015
This is supported by the finding that ascites contained more cleaved than intact IGFBP-4 (P < 0.03).
Insulin-like growth factor binding proteins 4-6.
Review
New
Bach, Australia. In Best Pract Res Clin Endocrinol Metab, Oct 2015
IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances.
Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
New
Oxvig et al., Århus, Denmark. In J Biol Chem, Oct 2015
STC1 potently (Ki = 68 pm) inhibits PAPP-A cleavage of IGFBP-4, and we show in a cell-based assay that STC1 effectively antagonizes PAPP-A-mediated type 1 IGF receptor (IGF1R) phosphorylation.
Angiogenesis Biomarkers May Be Useful in the Management of Patients With Indeterminate Pulmonary Nodules.
New
Borgia et al., Chicago, United States. In Ann Thorac Surg, Aug 2015
Our previously reported multi-analyte classification panel was refined to include interleukin (IL)-6, IL-10, IL-1 receptor antagonist (RA), tumor necrosis factor (TNF)-α, insulin-like growth factor binding protein (IGFBP)-5, IGFBP-4, IGF-2, stromal cell-derived factor (SDF)-1(α+β), HB-EGF, and HGF resulting in improved accuracy and a validated negative predictive value of 96.4%.
Rac1 Regulates Endometrial Secretory Function to Control Placental Development.
New
Bagchi et al., Winston-Salem, United States. In Plos Genet, Aug 2015
Consequently, the Rac1-null decidual cells failed to secrete vascular endothelial growth factor A, which is a critical regulator of decidual angiogenesis, and insulin-like growth factor binding protein 4, which regulates the bioavailability of insulin-like growth factors that promote proliferation and differentiation of trophoblast cell lineages in the ectoplacental cone.
The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.
Conover et al., Rochester, United States. In Plos One, 2014
Furthermore, PAPP-A was expressed and translated in NMRs cells and retained IGF-dependent proteolytic activity towards IGFBP-4 and IGF-independent activity towards IGFBP-5.
Significance of IGFBP-4 in the development of fetal growth restriction.
GeneRIF
Gruslin et al., Ottawa, Canada. In J Clin Endocrinol Metab, 2012
role of IGFBP-4 in regulating IGF bioavailability and provide new clues for the prevention and treatment of FGR (Fetal growth restriction).
Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients.
GeneRIF
Silani et al., Milano, Italy. In Muscle Nerve, 2012
This study demonistrated that IGFBP4 was significantly decreased in skeletal muscel in patient with amyotrophic lateral sclerosis.
Association of IGF1 gene haplotypes with high myopia in Chinese adults.
GeneRIF
Yip et al., Hong Kong, Hong Kong. In Arch Ophthalmol, 2012
IGF1 haplotypes are associated with genetic susceptibility to high myopia in Chinese adults, whereas IGFBP3 and IGFBP4 are unlikely to be important in the genetic predisposition to high myopia
Insulin-like growth factor binding protein-4 differentially inhibits growth factor-induced angiogenesis.
GeneRIF
Brooks et al., West Scarborough, United States. In J Biol Chem, 2012
The resistance of VEGF-stimulated angiogenesis to IGFBP-4 inhibition appears to depend on sustained activation of p38 MAPK as blocking its activity restored the anti-angiogenic effects of IGFBP-4 on VEGF-induced blood vessel growth in vivo
GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4.
GeneRIF
Xu et al., Cincinnati, United States. In Cytotherapy, 2011
knockdown results in decreased differentiation potential of mesenchymal stromal cells
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.
Impact
GeneRIF
Komuro et al., Chiba, Japan. In Nature, 2008
IGFBP-4 is an inhibitor of the canonical Wnt signalling required for cardiogenesis and provides a molecular link between insulin-like growth factor signalling and Wnt signalling
Insulin-like growth factor-binding proteins and bone metabolism.
Review
Conover, Rochester, United States. In Am J Physiol Endocrinol Metab, 2008
This review focuses on recent findings from cell culture, rodent models, and clinical studies concerning local IGFBP-2, IGFBP-4, and IGFBP-5 action in bone.
Insulin-like growth factor binding protein-5 in osteogenesis: facilitator or inhibitor?
Review
Rotwein et al., Portland, United States. In Growth Horm Igf Res, 2007
IGF action is mediated by the IGF-I receptor and additionally is regulated by six high-affinity IGF binding proteins (IGFBP-1 through IGFBP-6), of which IGFBP-4 and IGFBP-5 are most abundant in bone.
Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs.
Review
Conover et al., Rochester, United States. In Growth Horm Igf Res, 2007
In the early 1990s several laboratories reported novel protease activity against insulin-like growth factor binding protein-4 (IGFBP-4) in media conditioned by several cell types.
Biology of insulin-like growth factor binding protein-4 and its role in cancer (review).
Review
GeneRIF
Winslet et al., London, United Kingdom. In Int J Oncol, 2006
Overexpression of IGFBP-4 in vivo has been reported to decrease the growth of prostate cancer and altered expression of IGFBP-4 in vivo in colon and other cancers needs to be explored as locally available IGFs appear to stimulate mitogenesis. (review)
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