Calnuc function in endosomal sorting of lysosomal receptors.
Sherbrooke, Canada. In Traffic, Feb 2016
Using biochemical and microscopy assays, we showed that Calnuc depletion (by siRNA) causes the misdelivery to and degradation in lysosomes of CI-MPR and Sortilin due to a defect in the endosomal recruitment of retromers, which are key components of the endosome-to-Golgi retrieval machinery.
The role and interaction of imprinted genes in human fetal growth.
London, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, Apr 2015
We have found that the expression of paternally expressing insulin-like growth factor 2 (IGF2), its receptor IGF2R, and the IGF2/IGF1R ratio in CVS tissues significantly correlate with crown-rump length and birthweight, whereas term placenta expression shows no correlation.
Madagascar. In Unknown Journal, Feb 2015
GCs are required for the differentiation of mesenchymal stem cells to bone cells but in pharmacologic doses they reduce osteoblast proliferation and differentiation, they partially inhibit the production of IL-1 and –6 and inhibit the bone resorbing activity of these cytokines, they interfere with the receptor activator of the nuclear factor-κB ligand (RANKL or TRANCE)-osteoprotegerin (OPG) axis and GCs inhibit IGF-II receptor expression in osteoblasts and decrease the expression of IGFBP-3, -4, and -5 in osteoblasts.
Genetic associations with diminished ovarian reserve: a systematic review of the literature.
New York City, United States. In J Assist Reprod Genet, 2014
RESULTS: Twenty-one articles identified genes associated with DOR: one gene mutation (FMR1), three polymorphisms (GDF9, FSHR, and ESR1), and seven genes differentially expressed between women with DOR and controls (AMH, LHCGR, IGF1, IGF2, IGF1R, IGF2R and GREM1).
Developmental and epigenetic anomalies in cloned cattle.
Saint-Hyacinthe, Canada. In Reprod Domest Anim, 2012
By analysing differentially methylated regions (DMRs) of imprinted genes SNRPN, H19 and the IGF2R in cattle, we demonstrated that there is a generalized hypomethylation of the imprinted allele and the biallelic expression of embryos produced by SCNT when compared to the methylation patterns observed in vivo (artificially inseminated).