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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Insulin-like growth factor binding protein 5

IGF binding protein 5, IGFBP-5, Insulin-Like Growth Factor Binding Protein 5
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor Binding Protein 3, IGFBP-4, IGFBP-2
Papers on IGF binding protein 5
Differential expression of human placental PAPP-A2 over gestation and in preeclampsia.
New
Winn et al., Aurora, United States. In Placenta, Jan 2016
INTRODUCTION: Pregnancy Associated Plasma Protein A2 (PAPP-A2) is a pregnancy related insulin-like growth factor binding protein-5 (IGFBP-5) protease, known to be elevated in preeclampsia.
Effects of insulin-like growth factor-I during early postnatal period in intrauterine growth-restricted rats.
New
Shimizu et al., Tokyo, Japan. In Pediatr Int, Jan 2016
There were no significant differences in serum IGFBP3 and IGFBP5, hepatic IGF-I and IGFBP-5 mRNA, and brain IGF mRNA levels.
PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice.
New
Christians et al., Canada. In Growth Horm Igf Res, Dec 2015
OBJECTIVE: Pregnancy associated plasma protein-A2 (PAPP-A2) is a protease that cleaves insulin-like growth factor binding protein-5 (IGFBP-5), the most abundant IGFBP in bone.
IGF-I and IGF-II effects on local IGF system and signaling pathways in gilthead sea bream (Sparus aurata) cultured myocytes.
New
GutiƩrrez et al., Karaj, Iran. In Gen Comp Endocrinol, Dec 2015
Both IGFs increased the expression of IGF-I and IGFBP-5, but showed different effects on the receptors, with IGF-I suppressing the expression of both isoforms (IGF-IRa and IGF-IRb) and IGF-II up-regulating only IGF-IRb.
Pitavastatin Regulates Ang II Induced Proliferation and Migration via IGFBP-5 in VSMC.
New
Kang et al., Taegu, South Korea. In Korean J Physiol Pharmacol, Nov 2015
Ang II promotes fibrotic factor like IGFBP5, which mediates the profibrotic effects of Ang II in the heart and kidneys, lung and so on.
Pappa2 deletion alters IGFBPs but has little effect on glucose disposal or adiposity.
New
Amiri et al., Canada. In Growth Horm Igf Res, Oct 2015
The aim of this study was to examine the effects of an IGFBP-5 protease, pregnancy associated plasma protein-A2 (PAPP-A2), on glucose metabolism and susceptibility to diet-induced obesity.
Insulin-like growth factor binding proteins 4-6.
Review
New
Bach, Australia. In Best Pract Res Clin Endocrinol Metab, Oct 2015
IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances.
IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.
Feghali-Bostwick et al., Charleston, United States. In Plos One, 2014
We previously reported that IGFBP-5 is a pro-fibrotic factor that induces extracellular matrix (ECM) production and deposition.
The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.
Conover et al., Rochester, United States. In Plos One, 2014
Furthermore, PAPP-A was expressed and translated in NMRs cells and retained IGF-dependent proteolytic activity towards IGFBP-4 and IGF-independent activity towards IGFBP-5.
Pappa2 deletion in mice affects male but not female fertility.
Hessels et al., Canada. In Reprod Biol Endocrinol, 2014
BACKGROUND: Recent studies have found associations between the gene encoding pregnancy associated plasma protein-A2 (PAPP-A2), a protease of insulin-like growth factor binding protein -5 (IGFBP-5), and measures of female reproductive performance in cattle.
[Neuromuscular system and aging: involutions and implications].
Review
Paillard, Tarbes, France. In Geriatr Psychol Neuropsychiatr Vieil, 2013
The activity of the protein kinase (Akt) that stimulates the synthesis of regulation proteins (mTOR, p70S6, IGFBP-5) declines whereas the factors of degradation of proteins (NF-kappa B) are activated.
An ocular view of the IGF-IGFBP system.
Review
Grant et al., Gainesville, United States. In Growth Horm Igf Res, 2013
IGFBP-5 has recently been linked to mediating fibrosis in proliferative vitreoretinopathy but also reduces neovascularization.
IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.
Review
Flint et al., Glasgow, United Kingdom. In Biochem Soc Trans, 2009
Recently, IGFBP-5 [IGF (insulin-like growth factor)-binding protein-5] has also been shown to induce similar effects on TGFbeta1, and is strongly implicated in the process of senescence.
Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences.
Review
International ALS Collaborative Group et al., Buenos Aires, Argentina. In Horm Res, 2008
The majority of insulin-like growth factor (IGF)-I and IGF-II circulate in the serum as a complex with the insulin-like growth factor binding protein (IGFBP)-3 or IGFBP-5, and an acid-labile subunit (ALS).
Growth hormone and the insulin-like growth factor system in myogenesis.
Review
Impact
Coolican et al., Syracuse, United States. In Endocr Rev, 1996
The effects of IGFs are significantly modulated by IGFBPs secreted by myoblasts in serum-free medium, inhibitory IG-FBPs-4 and -6 are expressed and secreted by L6A1 myoblasts, while expression of IGFBP-5 rises dramatically as differentiation proceeds.
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