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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Immunoglobulin heavy constant alpha 1

IgA1
Top mentioned proteins: IgA, HAD, IgM, CAN, ACID
Papers on IgA1
Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro.
New
Chen et al., Shanghai, China. In Acta Pharmacol Sin, Feb 2016
AIM: Aberrantly glycosylated IgA1 is a key factor in the pathogenesis of IgA nephropathy (IgAN).
Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2.
New
Zhang et al., Wuhan, China. In Microbes Infect, Feb 2016
UNASSIGNED: IgA1 protease of Streptococcus suis serotype 2 (SS2) has been proven to be relative with virulence and immunogenicity, however, its protective efficacy remained to be evaluated.
Molecular Insights into the Pathogenesis of IgA Nephropathy.
Review
New
Monteiro et al., Paris, France. In Trends Mol Med, Dec 2015
To date, three key molecules have been implicated in IC formation, correlating with disease progression/recurrence after transplantation: galactose-deficient IgA1 (Gd-IgA1), IgG anti-Gd-IgA1 antibodies, and soluble CD89 (an Fc receptor for IgA).
House dust mite-specific IgA2 is associated with protection against eczema in allergic patients.
New
Savelkoul et al., Wageningen, Netherlands. In Allergy, Dec 2015
It is currently not known if and how the human IgA subclasses IgA1 and IgA2 contribute to the clinical status of house dust mite-allergic patients.
In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy.
New
Schena et al., Bari, Italy. In Kidney Int, Dec 2015
UNASSIGNED: Immunoglobulin A nephropathy (IgAN) is a worldwide disease characterized by the presence of galactose-deficient IgA1 deposits in the glomerular mesangium.
Role of IgA receptors in the pathogenesis of IgA nephropathy.
New
Monteiro et al., Paris, France. In J Nephrol, Dec 2015
IgAN is characterized by the accumulation of immune complexes containing polymeric IgA1 in mesangial areas.
Diagnosis and monitoring of IgA nephropathy: the role of biomarkers as an alternative to renal biopsy.
Review
New
Delanghe et al., Gent, Belgium. In Autoimmun Rev, Oct 2015
The underlying pathogenesis of this autoimmune disease comprises the formation of immune complexes, including glycan-specific IgA1 or IgG antibodies and an aberrant glycosylation of IgA1.
Current Understanding of the Role of Complement in IgA Nephropathy.
Review
New
Novak et al., Lyon, France. In J Am Soc Nephrol, Jul 2015
Complement activation has a role in the pathogenesis of IgA nephropathy, an autoimmune disease mediated by pathogenic immune complexes consisting of galactose-deficient IgA1 bound by antiglycan antibodies.
Paradigm shift in activity assessment of IgA nephropathy - optimizing the next generation of diagnostic and therapeutic maneuvers via glycan targeting.
Review
New
Tomino et al., Tokyo, Japan. In Expert Opin Biol Ther, Apr 2015
However, recent evidence revealed that aberrantly glycosylated serum IgA1, mostly galactose-deficient IgA1 (Gd-IgA1) and immune complexes (ICs) with autoantibodies against glycan-containing epitopes on Gd-IgA1 are essential effector molecules.
[IgA Nephropathy. Facts, uncertainties, and potential causal therapy approaches].
Review
Raška et al., In Cas Lek Cesk, 2014
The disease is defined by the presence of dominant or co-dominant deposits of IgA1 in the glomerular mesangium.
IgA nephropathy: molecular mechanisms of the disease.
Review
Impact
Novak et al., Birmingham, United States. In Annu Rev Pathol, 2013
In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype.
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions.
Impact
Sollid et al., Oslo, Norway. In Nat Med, 2012
TG2-specific antibodies did not block enzymatic activity and served as substrates for TG2-mediated crosslinking when expressed as IgD or IgM but not as IgA1 or IgG1.
Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia.
Impact
Moura et al., Paris, France. In Nat Med, 2010
We show that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (TfR1)-bound polymeric IgA1 (pIgA1).
Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy.
GeneRIF
Zhang et al., Beijing, China. In Nephrol Dial Transplant, 2009
Gal-deficient IgA1 might be inherited in Chinese patients with immunoglobulin A nephropathy
Various expression patterns of alpha1 and alpha2 genes in IgA deficiency.
GeneRIF
Kondo et al., Gifu, Japan. In Allergol Int, 2009
Various expression patterns of alpha1 and alpha2 genes in IgA deficiency.
Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding.
GeneRIF
Herr et al., Cincinnati, United States. In Biochemistry, 2008
Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding are reported.
Increased frequency of Ig heavy-chain HS1,2-A enhancer *2 allele in dermatitis herpetiformis, plaque psoriasis, and psoriatic arthritis.
GeneRIF
Frezza et al., Roma, Italy. In J Invest Dermatol, 2008
There was an increased frequency of the (*)2 allele of HS1,2-A in dermatitis herpetiformis, plaque psoriatic, and psoriatic arthritis patients.
Alleles and isoforms of human membrane-bound IgA1.
GeneRIF
Chang et al., Taiwan. In Mol Immunol, 2008
Alleles and isoforms of human membrane-bound IgA1.
Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.
Impact
Bjorkman et al., Pasadena, United States. In Nature, 2003
Here we present crystal structures of human FcalphaRI alone and in a complex with the Fc region of IgA1 (Fcalpha).
Nontypeable Haemophilus influenzae in carriage and disease: a difference in IgA1 protease activity levels.
Impact
Sayers et al., Sheffield, United Kingdom. In Jama, 2002
OBJECTIVES: To compare IgA1 protease activity in nontypeable H influenzae strains isolated from patients with symptomatic Haemophilus infection (sputum, cerebrospinal fluid, blood, or normally sterile tissue) vs strains from throat swabs of asymptomatic carriers and to compare iga gene carriage and variability in nontypeable H influenzae strains.
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