Assembly of IFT trains at the ciliary base depends on IFT74.
Worcester, United States. In Curr Biol, Jul 2015
The IFT-B core proteins IFT74 and IFT81 interact directly through central and C-terminal coiled-coil domains, and recently it was shown that the N termini of these proteins form a tubulin-binding module important for ciliogenesis.
Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46.
Moscow, United States. In J Biol Chem, 2010
As isolated from C. reinhardtii flagella, IFT complex B can be further reduced to a approximately 500-kDa core that contains IFT88, 2x IFT81, 2x IFT74/72, IFT52, IFT46, IFT27, IFT25, and IFT22.
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
Bethesda, United States. In Bmc Neurol, 2005
RESULTS: Candidate gene sequencing at this locus revealed the presence of a disease segregating stop mutation (Q342X) in the intraflagellar transport 74 (IFT74) gene in family 476 (F476), but no mutation was detected within IFT74 in family 2 (F2).
Primary cilia of human endothelial cells disassemble under laminar shear stress.
New York City, United States. In J Cell Biol, 2004
We identified primary cilia and centrosomes in cultured human umbilical vein endothelial cells (HUVEC) by antibodies to acetyl-alpha-tubulin and capillary morphogenesis gene-1 product (CMG-1), a human homologue of the intraflagellar transport (IFT) protein IFT-71 in Chlamydomonas.