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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Intraflagellar transport 74 homolog

IFT74, CMG-1
Top mentioned proteins: Als, alpha-tubulin, PCNA, AGE, V1a
Papers on IFT74
Assembly of IFT trains at the ciliary base depends on IFT74.
New
Witman et al., Worcester, United States. In Curr Biol, Jul 2015
The IFT-B core proteins IFT74 and IFT81 interact directly through central and C-terminal coiled-coil domains, and recently it was shown that the N termini of these proteins form a tubulin-binding module important for ciliogenesis.
Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites?
Lorentzen et al., Martinsried, Germany. In Bioessays, 2014
A recent study using purified IFT complexes has identified a tubulin-binding module in the two core IFT proteins IFT74 and IFT81 that likely serves to bind and transport tubulin within cilia.
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
Impact
Lorentzen et al., Martinsried, Germany. In Science, 2013
Here, we found that the two core IFT proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74.
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.
Blacque et al., Dublin, Ireland. In Plos Genet, 2012
Finally, C. elegans ARL-13 undergoes IFT-like motility and quantitative protein complex analysis of human ARL13B identified functional associations with IFT-B complexes, mapped to IFT46 and IFT74 interactions.
Katanin localization requires triplet microtubules in Chlamydomonas reinhardtii.
Dutcher et al., Saint Louis, United States. In Plos One, 2012
Unlike IFT proteins, katanin p80 does not localize to the transition fibers of the basal bodies based on an analysis of the uni1 mutant as well as the lack of colocalization of katanin p80 with IFT74.
Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46.
Cole et al., Moscow, United States. In J Biol Chem, 2010
As isolated from C. reinhardtii flagella, IFT complex B can be further reduced to a approximately 500-kDa core that contains IFT88, 2x IFT81, 2x IFT74/72, IFT52, IFT46, IFT27, IFT25, and IFT22.
Novel role for the intraflagellar transport protein CMG-1 in regulating the transcription of cyclin-D2, E-cadherin and integrin-alpha family genes in mouse spermatocyte-derived cells.
GeneRIF
Hara et al., Tokyo, Japan. In Genes Cells, 2010
The CMG-1 serves as a transcriptional regulator of proliferation and adhesion-associated genes in early stage male germ-line cells in the testis.
Retrograde intraflagellar transport mutants identify complex A proteins with multiple genetic interactions in Chlamydomonas reinhardtii.
Dutcher et al., Saint Louis, United States. In Genetics, 2009
These bulges contain the complex B component IFT74/72, but not alpha-tubulin or p28, a component of an inner dynein arm, which suggests specificity with respect to the proteins that accumulate in these bulges.
Chromosome 9p-linked families with frontotemporal dementia associated with motor neuron disease.
French Research Network on FTD/FTD-MND et al., France. In Neurology, 2009
We found no disease-causing mutations by sequencing 29 candidate genes including IFT74 and no copy number variations in the 9p region.
Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.
GeneRIF
Rogaeva et al., Toronto, Canada. In Neurobiol Aging, 2008
The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset.
Tissue expression patterns identify mouse cilia genes.
GeneRIF
Bergman et al., Lexington, United States. In Physiol Genomics, 2008
Ift74 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells.
GeneRIF
Hara et al., Tokyo, Japan. In Mol Reprod Dev, 2006
Results identify a cDNA encoding the mouse ortholog of capillary morphogenesis gene (CMG)-1, and suggest that CMG-1 may play a role in the transcriptional regulation of the cyclin D2 gene.
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
Traynor et al., Bethesda, United States. In Bmc Neurol, 2005
RESULTS: Candidate gene sequencing at this locus revealed the presence of a disease segregating stop mutation (Q342X) in the intraflagellar transport 74 (IFT74) gene in family 476 (F476), but no mutation was detected within IFT74 in family 2 (F2).
Characterization of the intraflagellar transport complex B core: direct interaction of the IFT81 and IFT74/72 subunits.
Cole et al., Moscow, United States. In J Biol Chem, 2005
In this study, we have used increased ionic strength to remove four peripheral subunits from the IFT complex B of Chlamydomonas reinhardtii, revealing a 500-kDa core that contains IFT88, IFT81, IFT74/72, IFT52, IFT46, and IFT27.
Primary cilia of human endothelial cells disassemble under laminar shear stress.
Piperno et al., New York City, United States. In J Cell Biol, 2004
We identified primary cilia and centrosomes in cultured human umbilical vein endothelial cells (HUVEC) by antibodies to acetyl-alpha-tubulin and capillary morphogenesis gene-1 product (CMG-1), a human homologue of the intraflagellar transport (IFT) protein IFT-71 in Chlamydomonas.
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