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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Interferon gamma receptor 1

IFN-gammaR, IFNGR1, IFN-gammaR1, interferon gamma receptor
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IFN-gamma, CAN, HAD, STAT1, IL-12
Papers on IFN-gammaR
Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.
New
Rodriguez et al., Rochester, United States. In Plos Pathog, Dec 2015
Multiple crosses with defined knockout mice (Rag1, Mda5, Mavs, Ifnar1, Ifngr1, and Tlr3) established that the mechanism operates via MDA5 and MAVS and is fully independent of the adaptive immune system.
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
New
Lucas et al., United States. In J Biol Chem, Dec 2015
In contrast Serp-1 but not NSP improves survival in a lethal murine gammaherpesvirus68 (MHV68) infection in interferon gamma receptor deficient mice (IFNγR-/-).
[Receptor tyrosine kinase KIT can regulate the expression of genes involved in spontaneous regression of neuroblastoma].
New
Prassolov et al., Moscow, Russia. In Mol Biol (mosk), Nov 2015
In addition, there is the upregulation of genes that stimulate the recognition of malignant cells by the immune system, such as genes of major histocompatibility complex class-I HLA-B and HLA-C, and interferon-γ receptor genes IFNGR1 and IFNGR2.
Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV-8.
Review
New
Casanova et al., Paris, France. In Pediatr Blood Cancer, Nov 2015
Recent studies have shown that classic KS of childhood can result from rare single-gene inborn errors of immunity, with mutations in WAS, IFNGR1, STIM1, and TNFRSF4.
Host susceptibility to non-tuberculous mycobacterial infections.
Review
New
Holland et al., Bethesda, United States. In Lancet Infect Dis, Aug 2015
So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection.
Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells.
Mat Junit et al., Kuala Lumpur, Malaysia. In Peerj, 2014
The antioxidant-rich leaf extract of T. indica also altered the expression of proteins that are involved in the Coagulation System and the Intrinsic Prothrombin Activation Pathway (KNG1, SERPINE1, FGG), Superpathway of Cholesterol Biosynthesis (MVK), Immune protection/antimicrobial response (IFNGR1, LEAP2, ANXA3 and MX1) and Xenobiotic Metabolism Signaling (ALDH6A1, ADH6).
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.
Review
Casanova et al., New York City, United States. In Semin Immunol, 2014
Since 1996, nine MSMD-causing genes, including seven autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, ISG15, and IRF8) and two X-linked (NEMO, and CYBB) genes have been discovered.
Association of Genetic Polymorphisms of IFNGR1 with the Risk of Pulmonary Tuberculosis in Zahedan, Southeast Iran.
Safdari et al., Zāhedān, Iran. In Tuberc Res Treat, 2014
The present study was undertaken to find out the possible association between interferon-gamma (IFN-γ) receptor 1 (IFNGR1) gene polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample of Iranian population.
Pineal germinoma in a child with interferon-γ receptor 1 deficiency. case report and literature review.
Review
Marazzi et al., Genova, Italy. In J Clin Immunol, 2014
The diagnosis of IFN-γR1 deficiency (523delT/523delT in IFNGR1 gene) was subsequently made.
[Interferon-gamma receptor 1 deficiency in a 19-month-old child: case report and literature review].
Review
Zhao et al., Nanjing, China. In Zhonghua Er Ke Za Zhi, 2014
OBJECTIVE: To analyze the clinical manifestation of interferon gamma receptor 1 deficiency (IFN-γR1 deficiency) and to improve the recognition of this disease in children, decrease diagnostic errors and missed diagnosis.
A novel internalization motif regulates human IFN-γ R1 endocytosis.
GeneRIF
Rosenzweig et al., Buenos Aires, Argentina. In J Leukoc Biol, 2012
A novel endocytosis motif shares characteristics of tyrosine-based and dileucine-based internalization sequences and is highly conserved in IFN-gamma receptors across species.
IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.
GeneRIF
Wang et al., Chapel Hill, United States. In Eur J Immunol, 2012
these results demonstrate that IFN-gammaR may play a key role in CD4( ) T cell-mediated beta-cell destruction
Innate IFN-γ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection.
GeneRIF
Way et al., Minneapolis, United States. In J Immunol, 2012
Absence of early innate IFN-gamma production in transgenic mice with combined defects in both IL-12 and type I IFN receptor negates the impact of programmed death ligand-1 blockade.
Monocyte-derived CD40 expression is regulated by interferon-γ/interferon-γ receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells.
GeneRIF
Xu et al., Jinan, China. In Transplant Proc, 2012
Monocyte-derived CD40 expression is regulated by interferon-gamma/interferon-gamma receptor-1 pathway when acting as a bridge during their interaction with T cells and allogeneic endothelial cells.
Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol.
GeneRIF
Roy et al., Calcutta, India. In Plos Pathog, 2011
Cholesterol dependent modulation of IFNgamma mediated receptor subunit interaction in Leishmania donovani infected macrophages involve differential raft partitioning of IFNgammaR subunits.
MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA.
Impact
Ding et al., New York City, United States. In Nat Immunol, 2006
The MyD88 adaptor protein is critical in Toll-like receptor and interleukin 1 receptor (IL-1R) signaling, but has not been linked to interferon-gamma receptor (IFN-gammaR) signaling.
Sensory neurons regulate the effector functions of CD8+ T cells in controlling HSV-1 latency ex vivo.
Impact
Hendricks et al., Pittsburgh, United States. In Immunity, 2005
This nonredundant efficacy of CD8+ T cell effector mechanisms in maintaining viral latency is explained as follows: (1) a subset of neurons that expresses IFN-gamma receptors (IFN-gamma R+) and Qa 1 responds to IFN-gamma, but Qa 1 engagement of CD94/NKG2a blocks LG exocytosis by CD8+ T cells; (2) another neuronal subset is responsive to LG because it lacks Qa 1 and is refractory to IFN-gamma because it also lacks IFN-gamma R. In the latter subset, LG appear to provide a nonlethal block of viral reactivation.
Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies.
Impact
Holland et al., Bethesda, United States. In Lancet, 2005
BACKGROUND: Interferon gamma receptor 1 (IFNgammaR1) deficiency is a primary immunodeficiency with allelic dominant and recessive mutations characterised clinically by severe infections with mycobacteria.
Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.
Impact
Casanova et al., Paris, France. In Nat Genet, 2003
Individuals with mutations in either chain of the IFN-gamma receptor (IFN-gammaR) are susceptible to infection with mycobacteria.
Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection.
Impact
Virgin et al., Saint Louis, United States. In Immunity, 2002
The gammaHV68 RCA protein was also important for persistent viral replication and virulence in IFNgammaR(-/-) mice.
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