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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Interferon, gamma

IFN-gamma
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: IL-4, IL-10, CAN, Interleukin-2, Interleukin-6
Papers using IFN-gamma antibodies
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Supplier
Nixon Douglas F., In PLoS ONE, 2009
... IFNgamma ELISA antibody pairs were purchased from eBioscience.
Papers on IFN-gamma
Interferon Gamma Potentiates the Injury Caused by MPP(+) on SH-SY5Y Cells, Which is Attenuated by the Nitric Oxide Synthases Inhibition.
New
Titze-de-Almeida et al., Brasília, Brazil. In Neurochem Res, 09 Nov 2014
First of all, IFN-gamma sensitized cells to the neurotoxin MPP(+), as determined by MTT (3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide) assay.
Early HIV-1 infection is associated with reduced frequencies of cervical Th17 cells.
New
Kaul et al., Winnipeg, Canada. In J Acquir Immune Defic Syndr, 07 Nov 2014
While CCR6+CCR10- cells did not differ in HIV receptor expression, these cells produced higher levels of IFN-gamma and IL17.
Differential clinical symptoms among acute phase Indian patients revealed significant association with dengue viral load and serum IFN-gamma level.
New
Tripathi et al., Calcutta, India. In J Clin Virol, 16 Oct 2014
OBJECTIVE: This study was carried out during 2012-2013 to evaluate the association of WHO-classified dengue disease symptoms with viral load (VL) and serum IFN-gamma levels in dengue patients from India.
[In vitro anti-tumor effect of human dendritic cells vaccine induced by astragalus polysacharin: an experimental study].
New
Chen et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, 30 Sep 2014
Levels of IL-12 and IFN-gamma in co-cultured supernatant were detected by ELISA.
[Comparative analysis of informative-diagnostic properties of mucosa immune-reactivity parameters].
New
In Zh Mikrobiol Epidemiol Immunobiol, May 2014
Saline and urogenital tract mucosa discharge was analyzed for IgG, sIgA and secretory component, IL-1beta, 4, 6, 8, 9, 10, 12, IFNgamma, TNFalpha and GM-CSF, TLR-2, TLR-3, TLR-4, TLR-8 gene expression levels as well as content of lysozyme, total protein and leucocytes.
[Towards novel tuberculosis and leprosy vaccine development: the role of Th1-inducing peptide in cytotoxic T cell differentiation].
Review
New
Makino et al., In Nihon Hansenbyo Gakkai Zasshi, Dec 2013
We found that this peptide induced the expression of T-bet and TATA box binding protein-associated factor that can induce the chromatin remodeling of ifn-gamma gene, and as a result induced Th1 differentiation even in the absence of IFN-gamma and IL-12.
Impact of mast cells on the skin.
Review
New
Conti et al., Thessaloníki, Greece. In Int J Immunopathol Pharmacol, Oct 2013
Activated macrophages by IFNgamma, cytotoxic T cells, activated mast cells and several cytokines are involved in the elimination of the parasites and immunoprotection.
[Pathogenesis of chronic inflammatory demyelinating polyneuropathy].
Review
New
Yamamura et al., In Nihon Rinsho, May 2013
Concerning cellular immune response, activity of IFN-gamma producing Th1 and IL-17 producing Th17 cells might be accelerated in patients with CIDP, while regulatory function of CD4+ CD25(high) Foxp3+ regulatory T cells might be diminished.
Cytokines in canine inflammatory bowel disease.
Review
Kander et al., Olsztyn, Poland. In Pol J Vet Sci, 2012
In this article, the expression of pro-inflammatory (IL-1, IL-2, IL-5, IL-6, IL-12, IL-18, IFN-gamma, TNF-alpha) and anti-inflammatory cytokines (IL-4, IL-10) was compared in canine patients with IBD based on clinical presentation, breed, lamina propria cell infiltrate and histopathological grade.
[Reccurent mycobacterial diseases in patients with impaired axis IL-12/INF-gamma].
Review
Grodzicki et al., In Przegl Lek, 2012
We present review of known defects of IL-12/IFNgamma axis and brief presentation of our own experience.
Negative impact of IFN-γ on early host immune responses to retroviral infection.
GeneRIF
Kassiotis et al., Hamilton, United States. In J Immunol, 2012
In a model of lactate dehydrogenase-elevating virus (LDV) and Friend virus coinfection, IFN-gamma production can have detrimental effects on early adaptive immune responses and virus control.
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
GeneRIF
Ernst et al., New York City, United States. In J Immunol, 2012
IFN-gamma production by CD8-positive effector T cells is influenced by CD4-positive T cells at the site of Mycobacterium tuberculosis infection in mice.
Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.
GeneRIF
Aune et al., Nashville, United States. In J Immunol, 2012
Tmevpg1 expression contributes to, but alone is not sufficient to, drive T helper(Th)1-cell dependent IFN-gamma expression.
NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.
GeneRIF
Kemeny et al., Singapore, Singapore. In J Immunol, 2012
IFN-gamma produced by natural killer (NK) cells is crucial for dendritic- and T-cell recruitment to the posterior mediastinal lymph node.
[Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation].
GeneRIF
Wang et al., Chengdu, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
Serum IFN-gamma and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Impact
Kemper et al., London, United Kingdom. In Nat Immunol, 2010
Furthermore, CD4(+) T cells in rheumatoid arthritis failed to switch, consequently producing excessive interferon-gamma (IFN-gamma).
Interleukin-23 drives intestinal inflammation through direct activity on T cells.
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, 2010
Through direct signaling into T cells, IL-23 drove intestinal T cell proliferation, promoted intestinal Th17 cell accumulation, and enhanced the emergence of an IL-17A(+)IFN-gamma(+) population of T cells.
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
Impact
O'Garra et al., London, United Kingdom. In Nature, 2010
Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling.
An IL-1beta-dependent switch in innate mucosal immunity?
Impact
Di Santo, Paris, France. In Immunity, 2010
The mechanisms that guide the development of mucosal-associated innate lymphoid cells (ILCs) producing IL-17, IL-22, and IFN-gamma are the subject of intense interest.
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.
Impact
Caligiuri et al., Columbus, United States. In Immunity, 2010
In the absence of IL-1beta, a substantially greater fraction of IL-1R1(hi) iNK cells differentiated to stage 4 NK cells and acquired the ability to kill and secrete IFN-gamma.
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