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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Jul 2015.

Interferon, gamma

IFN-gamma
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: IL-4, IL-10, CAN, Interleukin-2, Interleukin-6
Papers using IFN-gamma antibodies
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Supplier
Nixon Douglas F., In PLoS ONE, 2009
... IFNgamma ELISA antibody pairs were purchased from eBioscience.
Papers on IFN-gamma
Tumor promoting effects of myeloid derived suppressor cells are potentiated by hypoxia-induced expression of miR-210.
New
Chouaib et al., Stanford, United States. In Cancer Res, 23 Aug 2015
In splenic MDSC, miR-210 regulated Arg1, Cxcl12 and IL-16 at the levels of both mRNA and protein, the reversal of which under normoxic conditions decreased T cell suppressive effects and IFN-gamma production.
Diagnostic Usefulness of IFN-Gamma Releasing Assays Compared With Conventional Tests in Patients With Disseminated Tuberculosis.
New
Kim et al., Seoul, South Korea. In Medicine (baltimore), 31 Jul 2015
IFN-gamma releasing assays (IGRAs) such as T-SPOT.TB assay and QuantiFERON-TB In-Tube (QFT-GIT) have yielded promising results for the diagnosis of tuberculosis (TB).
Hepatitis B virus infection and interferon-inducible protein-10.
New
Fabiani, Pisa, Italy. In Clin Ter, May 2015
Here, IP-10 leads to recruitment of T cells, production of IFN-gamma by activated NK T cells, and then monokine induced by IFN-gamma (MIG) and IP-10 secretion by parenchymal and non-parenchymal cells, with a final positive feedback, perpetuating the immune cascade.
[Role of LIGHT signal pathway in Chlamydia muridarum urogenital infection in mice].
New
Wu et al., In Wei Sheng Wu Xue Bao, May 2015
Splenocytes from MoPn-infected LIGHT KO and wild type mice produced high levels of IFN-gamma and IL-17, but IL-4 and IL-5 couldn't be detected.
Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs.
New
Ganges et al., Barcelona, Spain. In Vet Res, Dec 2014
The humoral and interferon gamma responses as well as the CSFV RNA loads were monitored for 21 days post-vaccination.
Immunotherapeutic applications of NK cells.
Review
New
Rizzieri et al., In Pharmaceuticals (basel), Dec 2014
NK cell regulation is mediated through IFN-gamma and IL-15, important cytokines which can drive NK cell expansion in vivo.
Role of mast cells in atherosclerosis: a classical inflammatory disease.
Review
New
Conti et al., Cagliari, Italy. In Int J Immunopathol Pharmacol, Oct 2014
Macrophages, which generate pro-inflammatory cytokines, mainly interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-alpha), are deeply involved in atherosclerosis, as well as mast cells which generate several cytokines, including IL-6 and IFN-gamma, and chemokines such as eotaxin, MCP-1 and RANTES involved in monocyte recruitment and differentiation in the arterial wall.
[Recent progress in interferon induced protein GBP1 research].
Review
New
Zheng et al., In Bing Du Xue Bao, Jul 2014
Recent studies have proved that IFN-alpha, IFN-beta, IFN-gamma, IL1alpha, IL1beta, TNF-alpha and LPS can induce GBP1 expression; hence, the diverse biological functions of GBP1 have been gradually deduced and exploited.
[Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?].
Review
New
Wen et al., In Bing Du Xue Bao, Jul 2014
Three models have been proposed, including: (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion.
[Molecular aspects of renal desease].
Review
New
Khavinson et al., In Usp Fiziol Nauk, Apr 2014
The most important molecules inducing inflammation are cytokines (MCP-1, TNFalpha, IFN-gamma, IL-1,6,8,18), matrix metalloproteinases MMP-2,3,9,14, tissue inhibitors of metalloproteinases (TIMPs) and grow factors (VEGF PDGE FGF).
Negative impact of IFN-γ on early host immune responses to retroviral infection.
GeneRIF
Kassiotis et al., Hamilton, United States. In J Immunol, 2012
In a model of lactate dehydrogenase-elevating virus (LDV) and Friend virus coinfection, IFN-gamma production can have detrimental effects on early adaptive immune responses and virus control.
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
GeneRIF
Ernst et al., New York City, United States. In J Immunol, 2012
IFN-gamma production by CD8-positive effector T cells is influenced by CD4-positive T cells at the site of Mycobacterium tuberculosis infection in mice.
Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.
GeneRIF
Aune et al., Nashville, United States. In J Immunol, 2012
Tmevpg1 expression contributes to, but alone is not sufficient to, drive T helper(Th)1-cell dependent IFN-gamma expression.
NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.
GeneRIF
Kemeny et al., Singapore, Singapore. In J Immunol, 2012
IFN-gamma produced by natural killer (NK) cells is crucial for dendritic- and T-cell recruitment to the posterior mediastinal lymph node.
[Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation].
GeneRIF
Wang et al., Chengdu, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
Serum IFN-gamma and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Impact
Kemper et al., London, United Kingdom. In Nat Immunol, 2010
Furthermore, CD4(+) T cells in rheumatoid arthritis failed to switch, consequently producing excessive interferon-gamma (IFN-gamma).
Interleukin-23 drives intestinal inflammation through direct activity on T cells.
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, 2010
Through direct signaling into T cells, IL-23 drove intestinal T cell proliferation, promoted intestinal Th17 cell accumulation, and enhanced the emergence of an IL-17A(+)IFN-gamma(+) population of T cells.
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
Impact
O'Garra et al., London, United Kingdom. In Nature, 2010
Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling.
An IL-1beta-dependent switch in innate mucosal immunity?
Impact
Di Santo, Paris, France. In Immunity, 2010
The mechanisms that guide the development of mucosal-associated innate lymphoid cells (ILCs) producing IL-17, IL-22, and IFN-gamma are the subject of intense interest.
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.
Impact
Caligiuri et al., Columbus, United States. In Immunity, 2010
In the absence of IL-1beta, a substantially greater fraction of IL-1R1(hi) iNK cells differentiated to stage 4 NK cells and acquired the ability to kill and secrete IFN-gamma.
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