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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Interferon, gamma

IFN-gamma
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: IL-4, IL-10, CAN, Interleukin-2, Interleukin-6
Papers using IFN-gamma antibodies
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Supplier
Nixon Douglas F., In PLoS ONE, 2009
... IFNgamma ELISA antibody pairs were purchased from eBioscience.
Papers on IFN-gamma
Submicroscopic infection of placenta by Plasmodium produces Th1/Th2 cytokine imbalance, inflammation and hypoxia in women from north-west Colombia.
New
Maestre et al., In Malar J, 27 Apr 2014
Messenger RNA expression of Fas, FasL; COX-1, COX-2, HIF , VEGF, and the cytokines IL-2, IL-4, IL-10, IFN-gamma and TNF, were measured in peripheral and placental blood using a quantitative PCR.
Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei.
New
Cao et al., In Malar J, 26 Apr 2014
Interferon-gamma (IFN-gamma), interleukin (IL)-4, IL-5, IL-13, IL-10, and TGF-beta levels were determined in splenocyte supernatants using enzyme-linked immunosorbent assay (ELISA).
Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series.
New
Netea et al., In Bmc Infect Dis, 26 Apr 2014
Based on pathophysiological mechanisms and limited pre-clinical and clinical data, adjunctive immune-stimulatory therapy with interferon-gamma (IFN-gamma) may represent a promising candidate to improve outcome of invasive fungal infections by enhancing host defence mechanisms.
Cytokine profiles and hepatic injury in occult hepatitis C versus chronic hepatitis C virus infection.
New
Arafa et al., Al Manşūrah, Egypt. In Int J Immunopathol Pharmacol, Jan 2014
Serum levels of Th1 cytokines (IL-2, IFN-gamma) and Th2 (IL-4 and IL-10) were measured in 35 patients with occult HCV infection compared to 50 patients with chronic hepatitis C infection and 30 healthy controls.
Suppression of CD4+ T lymphocyte activation in vitro and experimental encephalomyelitis in vivo by the phosphatidyl inositol 3-kinase inhibitor PIK-75.
New
Rojo et al., Madrid, Spain. In Int J Immunopathol Pharmacol, Jan 2014
At low nanomolar concentrations (≤10 nM), PIK-75 inhibited naive CD4+ T cell proliferation, and IL-2 and IFN-gamma production induced by anti-CD3 plus anti-CD28.
[Pathogenesis of chronic inflammatory demyelinating polyneuropathy].
Review
New
Yamamura et al., In Nihon Rinsho, May 2013
Concerning cellular immune response, activity of IFN-gamma producing Th1 and IL-17 producing Th17 cells might be accelerated in patients with CIDP, while regulatory function of CD4+ CD25(high) Foxp3+ regulatory T cells might be diminished.
Cytokines in canine inflammatory bowel disease.
Review
Kander et al., Olsztyn, Poland. In Pol J Vet Sci, 2012
In this article, the expression of pro-inflammatory (IL-1, IL-2, IL-5, IL-6, IL-12, IL-18, IFN-gamma, TNF-alpha) and anti-inflammatory cytokines (IL-4, IL-10) was compared in canine patients with IBD based on clinical presentation, breed, lamina propria cell infiltrate and histopathological grade.
Molecular pathogenesis of B-cell posttransplant lymphoproliferative disorder: what do we know so far?
Review
Tousseyn et al., Leuven, Belgium. In Clin Dev Immunol, 2012
Genetic studies have linked translocations (involving C-MYC, IGH, BCL-2), various copy number variations, DNA mutations (PIM1, PAX5, C-MYC, RhoH/TTF), and polymorphisms in both the host (IFN-gamma, IL-10, TGF-beta, HLA) and the EBV genome to B-cell PTLD development.
[Advances in cytokine immune mechanisms of allergic rhinitis].
Review
Li et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2012
Th1 cells mainly produce of IFN-gamma (does not include IL-4 and IL-5), Th2 cells produce IL-4, IL-5, IL-9 and IL-13 (not including IFN-gamma).
IL-17 and IFN-γ production in peripheral blood following BCG vaccination and Mycobacterium tuberculosis infection in human.
Review
Hu et al., China. In Eur Rev Med Pharmacol Sci, 2012
BACKGROUND: During Mycobacterium tuberculosis (Mtb) infection, cells of the immune system rely on cytokines to regulate the activity of other immune and structural cells such as IFN-gamma and IL-4.
Negative impact of IFN-γ on early host immune responses to retroviral infection.
GeneRIF
Kassiotis et al., Hamilton, United States. In J Immunol, 2012
In a model of lactate dehydrogenase-elevating virus (LDV) and Friend virus coinfection, IFN-gamma production can have detrimental effects on early adaptive immune responses and virus control.
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
GeneRIF
Ernst et al., New York City, United States. In J Immunol, 2012
IFN-gamma production by CD8-positive effector T cells is influenced by CD4-positive T cells at the site of Mycobacterium tuberculosis infection in mice.
Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.
GeneRIF
Aune et al., Nashville, United States. In J Immunol, 2012
Tmevpg1 expression contributes to, but alone is not sufficient to, drive T helper(Th)1-cell dependent IFN-gamma expression.
NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.
GeneRIF
Kemeny et al., Singapore, Singapore. In J Immunol, 2012
IFN-gamma produced by natural killer (NK) cells is crucial for dendritic- and T-cell recruitment to the posterior mediastinal lymph node.
[Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation].
GeneRIF
Wang et al., Chengdu, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
Serum IFN-gamma and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Impact
Kemper et al., London, United Kingdom. In Nat Immunol, 2010
Furthermore, CD4(+) T cells in rheumatoid arthritis failed to switch, consequently producing excessive interferon-gamma (IFN-gamma).
Interleukin-23 drives intestinal inflammation through direct activity on T cells.
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, 2010
Through direct signaling into T cells, IL-23 drove intestinal T cell proliferation, promoted intestinal Th17 cell accumulation, and enhanced the emergence of an IL-17A(+)IFN-gamma(+) population of T cells.
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
Impact
O'Garra et al., London, United Kingdom. In Nature, 2010
Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling.
An IL-1beta-dependent switch in innate mucosal immunity?
Impact
Di Santo, Paris, France. In Immunity, 2010
The mechanisms that guide the development of mucosal-associated innate lymphoid cells (ILCs) producing IL-17, IL-22, and IFN-gamma are the subject of intense interest.
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.
Impact
Caligiuri et al., Columbus, United States. In Immunity, 2010
In the absence of IL-1beta, a substantially greater fraction of IL-1R1(hi) iNK cells differentiated to stage 4 NK cells and acquired the ability to kill and secrete IFN-gamma.
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