Immunoregulatory networks in human Chagas disease.
Belo Horizonte, Brazil. In Parasite Immunol, Aug 2014
Analysis of data obtained from several studies has led to the hypothesis that the indeterminate form is associated with an anti-inflammatory cytokine profile, represented by high expression of IL-10, while cardiac form is associated with a high production of IFN-gamma and TNF-alpha in relation to IL-10, leading to an inflammatory profile.
PCR-based techniques for leprosy diagnosis: from the laboratory to the clinic.
Rio de Janeiro, Brazil. In Plos Negl Trop Dis, Apr 2014
Serological tests and IFN-gamma releasing assays (IGRA) that employ humoral and cellular immune parameters, respectively, are also being used, but recent results indicate that quantitative PCR (qPCR) is a key technique due to its higher sensitivity and specificity.