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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Aug 2015.

Interferon, gamma

IFN-gamma
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: IL-4, IL-10, CAN, Interleukin-2, Interleukin-6
Papers using IFN-gamma antibodies
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Supplier
Nixon Douglas F., In PLoS ONE, 2009
... IFNgamma ELISA antibody pairs were purchased from eBioscience.
Papers on IFN-gamma
CTLA4-Ig suppresses development of experimental autoimmune uveitis in the induction and effector phases: comparison with blockade of interleukin-6.
New
Naka et al., Ibaraki, Japan. In Exp Eye Res, 19 Sep 2015
To investigate the differences between these biologics in the effector phase, in vitro restimulation analysis of LN cells obtained from EAU mice one week after immunization was performed and revealed that CTLA4-Ig, but not MR16-1, added to culture media could inhibit the proliferation of IRBP-specific CD4(+) T cells which possessed capacities of producing IFN-gamma and/or IL-17.
Increased Dietary Salt Intake Does Not Influence Influenza A Virus-Induced Disease Severity in Mice.
New
Gangappa et al., Atlanta, United States. In Viral Immunol, 18 Sep 2015
Following infection, despite higher levels of IFN-gamma cytokine in the lung as well as virus-neutralizing antibody in the serum of mice fed the lowest salt level, the amounts of dietary salt intake had no substantial impact on the disease severity or the ability to respond immunologically to the infection.
[Experimental study of dendritic cells transfected with cancer stem like cells RNA against 9L brain tumors].
New
Xu et al., Xining, China. In Beijing Da Xue Xue Bao, 18 Sep 2015
P=0.789).The concentration of IFN-gamma of DC-9LTS group[(157.08±7.25)
The 5-lipoxygenase (5-LOX) inhibitor zileuton reduces inflammation and infarct size with improvement in neurological outcome following cerebral ischemia.
New
Rachid et al., Belo Horizonte, Brazil. In Curr Neurovasc Res, 12 Sep 2015
Furthermore, by enzyme immunoassay (ELISA) increased brain levels of tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), chemokine (C-X-C motif) ligand 1 (CXCL1), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5) were detected in the vehicle-ischemic group, whereas in Zileuton-ischemic group presented reduction of these mediators.
Association between PD-1/PD-L1 and T regulate cells in early recurrent miscarriage.
New
Zhang et al., Qingdao, China. In Int J Clin Exp Pathol, Dec 2014
After PD-1 blockade there was no change in CD4+ CD25+ Treg cells percentage, while the CD4+ T cell percentage increased (P < 0.01), as well as the level of IFN-gamma in cells supernatant (P < 0.01).
Immunotherapeutic applications of NK cells.
Review
New
Rizzieri et al., In Pharmaceuticals (basel), Dec 2014
NK cell regulation is mediated through IFN-gamma and IL-15, important cytokines which can drive NK cell expansion in vivo.
Role of mast cells in atherosclerosis: a classical inflammatory disease.
Review
New
Conti et al., Cagliari, Italy. In Int J Immunopathol Pharmacol, Oct 2014
Macrophages, which generate pro-inflammatory cytokines, mainly interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-alpha), are deeply involved in atherosclerosis, as well as mast cells which generate several cytokines, including IL-6 and IFN-gamma, and chemokines such as eotaxin, MCP-1 and RANTES involved in monocyte recruitment and differentiation in the arterial wall.
[Recent progress in interferon induced protein GBP1 research].
Review
New
Zheng et al., In Bing Du Xue Bao, Jul 2014
Recent studies have proved that IFN-alpha, IFN-beta, IFN-gamma, IL1alpha, IL1beta, TNF-alpha and LPS can induce GBP1 expression; hence, the diverse biological functions of GBP1 have been gradually deduced and exploited.
[Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?].
Review
New
Wen et al., In Bing Du Xue Bao, Jul 2014
Three models have been proposed, including: (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion.
[Molecular aspects of renal desease].
Review
New
Khavinson et al., In Usp Fiziol Nauk, Apr 2014
The most important molecules inducing inflammation are cytokines (MCP-1, TNFalpha, IFN-gamma, IL-1,6,8,18), matrix metalloproteinases MMP-2,3,9,14, tissue inhibitors of metalloproteinases (TIMPs) and grow factors (VEGF PDGE FGF).
Negative impact of IFN-γ on early host immune responses to retroviral infection.
GeneRIF
Kassiotis et al., Hamilton, United States. In J Immunol, 2012
In a model of lactate dehydrogenase-elevating virus (LDV) and Friend virus coinfection, IFN-gamma production can have detrimental effects on early adaptive immune responses and virus control.
CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
GeneRIF
Ernst et al., New York City, United States. In J Immunol, 2012
IFN-gamma production by CD8-positive effector T cells is influenced by CD4-positive T cells at the site of Mycobacterium tuberculosis infection in mice.
Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells.
GeneRIF
Aune et al., Nashville, United States. In J Immunol, 2012
Tmevpg1 expression contributes to, but alone is not sufficient to, drive T helper(Th)1-cell dependent IFN-gamma expression.
NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.
GeneRIF
Kemeny et al., Singapore, Singapore. In J Immunol, 2012
IFN-gamma produced by natural killer (NK) cells is crucial for dendritic- and T-cell recruitment to the posterior mediastinal lymph node.
[Changes to IFN-γ and IP-10 in the arterial blood of premature infants before and after mechanical ventilation].
GeneRIF
Wang et al., Chengdu, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
Serum IFN-gamma and IP-10 levels increase after mechanical ventilation, suggesting that both may participate in the immune-inflammatory process of ventilation-induced lung injury.
Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells.
Impact
Kemper et al., London, United Kingdom. In Nat Immunol, 2010
Furthermore, CD4(+) T cells in rheumatoid arthritis failed to switch, consequently producing excessive interferon-gamma (IFN-gamma).
Interleukin-23 drives intestinal inflammation through direct activity on T cells.
Impact
Powrie et al., Oxford, United Kingdom. In Immunity, 2010
Through direct signaling into T cells, IL-23 drove intestinal T cell proliferation, promoted intestinal Th17 cell accumulation, and enhanced the emergence of an IL-17A(+)IFN-gamma(+) population of T cells.
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.
Impact
O'Garra et al., London, United Kingdom. In Nature, 2010
Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling.
An IL-1beta-dependent switch in innate mucosal immunity?
Impact
Di Santo, Paris, France. In Immunity, 2010
The mechanisms that guide the development of mucosal-associated innate lymphoid cells (ILCs) producing IL-17, IL-22, and IFN-gamma are the subject of intense interest.
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.
Impact
Caligiuri et al., Columbus, United States. In Immunity, 2010
In the absence of IL-1beta, a substantially greater fraction of IL-1R1(hi) iNK cells differentiated to stage 4 NK cells and acquired the ability to kill and secrete IFN-gamma.
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