APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.
Canberra, Australia. In Mol Psychiatry, Jan 2016
Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation processes (i.e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFNA5) might interact with the APOE*E2 allele.
The Emerging Role of Nuclear Viral DNA Sensors.
Princeton, United States. In J Biol Chem, Nov 2015
The interferon-inducible protein IFI16 was shown to bind nuclear viral DNA and initiate immune signaling, culminating in antiviral cytokine secretion.
The nucleic acid-sensing inflammasomes.
Cleveland, United States. In Immunol Rev, May 2015
Structural and biophysical studies have shed light on the mechanisms of nucleic acid recognition and signaling complex assembly involving the AIM2 (absent in myeloma 2) and IFI16 (γ-interferon-inducible protein 16) inflammasomes.
Innate immune recognition of DNA: A recent history.
Dublin, Ireland. In Virology, May 2015
Here we review the discoveries that led to an appreciation of the existence of cytosolic DNA sensor proteins, and discuss two key such sensors, cGAS and IFI16, in detail.