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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Immediate early response 3

IEX-1, IER3, PRG1, DIF-2
This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, NF-kappaB, HAD, p53, V1a
Papers on IEX-1
NT-3 protein levels are enhanced in the hippocampus of PRG1-deficient mice but remain unchanged in PRG1/LPA2 double mutants.
New
Roskoden et al., Magdeburg, Germany. In Neurosci Lett, Jan 2016
UNASSIGNED: The plasticity-related gene 1 (PRG1) modulates bioactive lipids at the postsynaptic density and is a novel player in neuronal plasticity and regulation of glutamatergic transmission at principal neurons.
Proinflammatory genes expression in granulocytes activated by native proteinase-binding fragments of anti-proteinase 3 IgG.
New
Sanak et al., Kraków, Poland. In J Physiol Pharmacol, Aug 2015
We observed a consistent upregulation of 17 genes (CYSLTR1, HPGD, IL1R1, IL1RL1, MAPK1, MAPK8, NR3C1, PLA2G7, PTGDR, CD302, DNAJB1, F2R, F2RL1, IER3, RAC1, RPL41, PTGER3), whereas other 9 genes were up-regulated only in some donors.
IER3 Promotes Expansion of Adipose Progenitor Cells in Response to Changes in Distinct Microenvironmental Effectors.
New
Ladoux et al., Nice, France. In Stem Cells, Aug 2015
Here we show that the immediate early response 3 gene (IER3) is preferentially expressed in APCs and is essential for APC proliferation and self-renewal.
Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.
New
Blackshear et al., United States. In J Leukoc Biol, Apr 2015
The decay rates of transcripts encoded by several early-response genes, including Cxcl1, Cxcl2, Ier3, Ptgs2, and Lif, were significantly slowed in TTP-deficient fibroblasts after TNF stimulation.
MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2.
New
Tang et al., Weifang, China. In Oncol Lett, Feb 2015
Furthermore, miR-30a overexpression upregulates BCL2A1, IER3 and cyclin D2 expression by inhibiting FOXL2.
Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia.
Wu et al., In Int Immunopharmacol, 2014
We found that mice lacking immediate early responsive gene X-1 (IEX-1) were prone to lipopolysaccharide (LPS) -induced endotoxemia.
Expression of IER3 in primary hepatocarcinoma: correlation with clinicopathological parameters.
Liang et al., Qingdao, China. In Asian Pac J Cancer Prev, 2014
BACKGROUND: Studies indicate the immediate early response gene 3 (IER3) is involved in many biological processes.
IER3 is a crucial mediator of TAp73β-induced apoptosis in cervical cancer and confers etoposide sensitivity.
Bae et al., South Korea. In Sci Rep, 2014
Here, we identified that IER3 is a novel target gene of TAp73β.
Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor.
Ma et al., Shanghai, China. In J Cancer, 2014
Northern blots also confirmed that KRT-7, FN14, IER3, and ID1 were deregulated in VBL-treated KB-3 cells.
Immediate early response gene X-1, a potential prognostic biomarker in cancers.
Review
Akilov et al., Boston, United States. In Expert Opin Ther Targets, 2013
INTRODUCTION: The immediate early response gene X-1 (IEX-1) plays a pivotal role in the regulation of cell apoptosis, proliferation, differentiation and metabolism.
Seven new loci associated with age-related macular degeneration.
Impact
AMD Gene Consortium et al., Regensburg, Germany. In Nat Genet, 2013
Our results include seven loci with associations reaching P < 5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL.
Current views on regulation and function of plasticity-related genes (PRGs/LPPRs) in the brain.
Review
Bräuer et al., Berlin, Germany. In Biochim Biophys Acta, 2013
Here, we discuss new findings on the neuron-specific transcriptional regulation of PRG1/LPPR4 and new insights into protein-protein interaction and signaling pathway regulation.
Clinical significance of IEX-1 expression in ovarian carcinoma.
GeneRIF
Wu et al., Zhengzhou, China. In Ultrastruct Pathol, 2011
Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy.
IEX-1 suppresses apoptotic damage in human intestinal epithelial Caco-2 cells induced by co-culturing with macrophage-like THP-1 cells.
GeneRIF
Shimizu et al., Tokyo, Japan. In Biosci Rep, 2011
IEX-1 plays a role in suppression of apoptosis and protects cells by controlling sensitivity to TNFalpha under both normal and inflammatory conditions.
Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis.
Review
GeneRIF
Schäfer et al., Kiel, Germany. In Eur J Cell Biol, 2011
IER3 plays a complex and to some extent contradictory role in cell cycle control and apoptosis. Effects of IER3 relate to an interference with certain signalling pathways
[Methylation status of IEX-1 gene promotor CpG island in malignant hematopoietic cell lines].
GeneRIF
Zheng et al., Fuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
Changes of methylation status of gene IEX-1 promoter CpG island correlates with hematologic malignancies.
[IEX-1: an unique protein in regulating apoptosis].
Review
Xiao et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011
Immediate early response gene X-1 (IEX-1) gene was discovered by Charles in 1993, which plays an important role in regulating apoptosis.
Early proliferation alteration and differential gene expression in human periodontal ligament cells subjected to cyclic tensile stress.
GeneRIF
Zhao et al., Chengdu, China. In Arch Oral Biol, 2011
IER3 is upregulated in human PDLCs subjected to tensile stress related to mechano-induced cell cycle arrest.
The molecular pathogenesis of myelodysplastic syndromes.
Review
Steensma et al., Boston, United States. In Cancer Biol Ther, 2010
Several genetic abnormalities, including mutations in RUNX1 (AML1), TET2, ASXL1 and TP53, have been discovered in a substantial fraction of MDS cases; genes rearranged or mutated less commonly in MDS include IER3, ATRX, RAS and FLT3.
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