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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Immediate early response 5

IER5, immediate early response 5
This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, POLYMERASE, CAN, AP-1, GADD45
Papers on IER5
IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.
New
Ohki et al., Tokyo, Japan. In Sci Rep, Dec 2015
Here we show that a p53 target gene, IER5, encodes an activator of HSF1.
Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.
New
Sakurai et al., Kanazawa, Japan. In Febs Lett, Dec 2015
Immediate-early response 5 (IER5) is a growth factor-inducible protein with homology to the N-terminus of IER2.
[Association of schizophrenia with variants of genes that encode transcription factors].
New
Zakharyan et al., Yerevan, Armenia. In Mol Biol (mosk), Nov 2015
Transcription factors c-Fos, c-Jun, and Ier5 are important regulators of neuronal plasticity and immune response.
HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.
New
Sakurai et al., Kanazawa, Japan. In Febs Lett, May 2015
HSF1 regulates the expression of the immediate-early response gene IER5, which encodes a protein that has roles in the stress response and cell proliferation.
Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.
Sakurai et al., Kanazawa, Japan. In Febs J, 2015
The serum-inducible and growth factor-inducible gene IER5 encodes a protein that acts as a regulator of cell proliferation.
Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities.
Drevets et al., Tulsa, United States. In Brain Behav Immun, 2013
A whole genome expression analysis of peripheral blood mononuclear cells yielded 12 protein-coding genes (ADM, APBB3, CD160, CFD, CITED2, CTSZ, IER5, NFKBIZ, NR4A2, NUCKS1, SERTAD1, TNF) that were differentially expressed between 29 unmedicated depressed patients with a mood disorder (8 bipolar disorder, 21 major depressive disorder) and 24 healthy controls (HCs).
Dose-dependent and gender-related radiation-induced transcription alterations of Gadd45a and Ier5 inhuman lymphocytes exposed to gamma ray emitted by (60)Co.
Karimi et al., Tehrān, Iran. In Radiat Prot Dosimetry, 2013
Growth arrest DNA damage-inducible 45a gene (Gadd45a) and immediate early response gene 5 (Ier5) have been emphasised as ideal radiation biomarkers in several reports.
Gene expression changes in melanoma metastases in response to high-dose chemotherapy during isolated limb perfusion.
van den Oord et al., Leuven, Belgium. In Pigment Cell Melanoma Res, 2012
Using a human 'model', in which the isolated limb is perfused with high doses of the chemotherapeutic melphalan (ILP), we identified a five-gene set (ATF3, CYR61, IER5, IL6, and PTGS2) of stress-induced genes that was consistently upregulated after ILP in all in-transit metastatic melanoma samples as well as in three melphalan-treated melanoma cell lines.
Radiation dose effect of DNA repair-related gene expression in mouse white blood cells.
Min et al., Shanghai, China. In Med Sci Monit, 2011
RAD50 (RAD50 homolog), PLK3 (polo-like kinase 3), GADD45A (growth arrest and DNA damage-inducible, alpha), DDB2 (damage-specific DNA-binding protein 2), BBC3 (BCL2-binding component 3) and IER5 (immediate early response 5) gene expression levels were found to undergo significant oscillating changes over a broad dose range of 2-8 Gy at post-exposure time points observed.
Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.
GeneRIF
Yamashita et al., Hamamatsu, Japan. In Plos One, 2010
Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia.
IGFBP-rP1, a potential molecule associated with colon cancer differentiation.
Lai et al., Hangzhou, China. In Mol Cancer, 2009
IGFBP-rP1 could upreguate Transgelin (TAGLN), downregulate SRY (sex determining region Y)-box 9(campomelic dysplasia, autosomal sex-reversal) (SOX9), insulin receptor substrate 1(IRS1), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), amphiregulin(schwannoma-derived growth factor) (AREG) and immediate early response 5-like(IER5L) in RKO, SW620 and CW2 colon cancer cells, verified by Real time Reverse Transcription Polymerase Chain Reaction (rtRT-PCR).
Induced expression of the IER5 gene by gamma-ray irradiation and its involvement in cell cycle checkpoint control and survival.
GeneRIF
Zhou et al., Beijing, China. In Radiat Environ Biophys, 2009
the early radiation-induced expression of IER5 affects radiosensitivity via disturbing radiation-induced cell cycle checkpoints
Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells.
Zhou et al., Beijing, China. In Int J Mol Med, 2007
DNA repair gene XPC, tumor protein p53 inducible protein 3 gene (TP53I3), immediate early response 5 gene, whose transcriptional levels were increased or depressed by IR in a dose-dependent trend within the dose range 0.05-10 Gy.
Microarray analysis of radiation response genes in primary human fibroblasts.
Sáfrány et al., Budapest, Hungary. In Int J Radiat Oncol Biol Phys, 2007
Twenty of these consensus radiation response genes were functionally categorized: most of them belong to the DNA damage response (GADD45A, BTG2, PCNA, IER5), regulation of cell cycle and cell proliferation (CDKN1A, PPM1D, SERTAD1, PLK2, PLK3, CYR61), programmed cell death (BBC3, TP53INP1) and signaling (SH2D2A, SLIC1, GDF15, THSD1) pathways.
Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 cells using cDNA microarray.
Wan et al., Hong Kong, Hong Kong. In Int J Oncol, 2005
Our data show that PSP-induced apoptosis in HL-60 cells might be mediated by up-regulation of early transcription factors such as AP-1, EGR1, IER2 and IER5, and down-regulation of NF-kappaB transcription pathways.
Gene expression in the brain across the sleep-waking cycle.
GeneRIF
Tononi et al., San Diego, United States. In Brain Res, 2001
Studies in rat found higher mRNA levels after waking and sleep deprivation for immediate early genes/transcription factors such as IER5
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