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Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

Id4
This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Id2, Id1, CAN, HAD, Id3
Papers on Id4
Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy.
New
Pierattelli et al., Florence, Italy. In Biophys J, Feb 2016
UNASSIGNED: Here, we present a structural and dynamic description of CBP-ID4 at atomic resolution.
Epigenetic regulation of ID4 in the determination of the BRCAness phenotype in breast cancer.
New
Roqué et al., Mendoza, Argentina. In Breast Cancer Res Treat, Jan 2016
Epigenetically, we found that the strongest predictors for BRCAness tumors were the methylations of MLH1 and PAX5 plus the unmethylations of CCND2 and ID4.
Inhibitor of DNA binding 4 functions as a tumor suppressor and is targetable by 5‑aza‑2'‑deoxycytosine with potential therapeutic significance in Burkitt's lymphoma.
New
Li et al., Zhengzhou, China. In Mol Med Report, Jan 2016
One important target for gene methylation analysis in non‑Hodgkin lymphoma (NHL) is inhibitor of DNA binding 4 (ID4).
Transcription and imprinting dynamics in developing postnatal male germline stem cells.
New
Cairns et al., Salt Lake City, United States. In Genes Dev, Dec 2015
To better understand, we conducted extensive genomic profiling at multiple postnatal stages on subpopulations enriched for particular markers (THY1, KIT, OCT4, ID4, or GFRa1).
Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.
New
Shahhoseini et al., Tehrān, Iran. In Iubmb Life, Nov 2015
NF-Y transcription factor, with defined CCAAT element-binding activities, target a gene family that encodes a group of basic helix-loop-helix ID factors (ID1-ID4), with or without CCAAT box at their promoter region.
Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival.
New
Iqbal et al., Singapore, Singapore. In Histopathology, Sep 2015
Recent studies have suggested that inhibitor of DNA binding 4 (ID4), as well as p53, participate in the transcriptional regulation of BRCA1.
Inhibitor of differentiation 4 (ID4): From development to cancer.
Review
Chaudhary et al., Atlanta, United States. In Biochim Biophys Acta, 2015
Highly conserved Inhibitors of DNA-Binding (ID1-ID4) genes encode multi-functional proteins whose transcriptional activity is based on dominant negative inhibition of basic helix-loop-helix (bHLH) transcription factors.
Hypomethylation of DNA-binding inhibitor 4 serves as a potential biomarker in distinguishing acquired tamoxifen-refractory breast cancer.
Cao et al., Tianjin, China. In Int J Clin Exp Pathol, 2014
OBJECTIVE: To explore the methylation status of DNA-binding inhibitor 4 (ID4) in tamoxifen-refractory (TR) breast cancer.
Transcriptional control of spermatogonial maintenance and differentiation.
Review
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Most of the transcription factors that have so far been identified as promoting SSC self-renewal (BCL6B, BRACHYURY, ETV5, ID4, LHX1, and POU3F1) are upregulated by glial cell line-derived neurotrophic factor (GDNF).
IGH@ translocations are prevalent in teenagers and young adults with acute lymphoblastic leukemia and are associated with a poor outcome.
Impact
Harrison et al., Sheffield, United Kingdom. In J Clin Oncol, 2014
Multiple partner genes were identified including CRLF2 (n = 35), five members of the CEPB gene family (n = 17), and ID4 (n = 11).
The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.
Review
Duan et al., Ningbo, China. In Plos One, 2013
A further subgroup meta-analysis by subtype of leukemia showed that CDKN2A, CDKN2B, ID4 genes were significantly hypermethylated in acute myeloid leukemia.
Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature.
Review
Groupe Francophone de Cytogénétique Hématologique et al., Paris, France. In Cancer Genet, 2013
Members of the CEBP gene family (n = 11), BCL2 (n = 3), ID4 (n = 3), EPOR (n = 2), and TRA/D@ (n = 1) were identified and demonstrated by quantitative real-time reverse transcriptase-polymerase chain reaction to be markedly up-regulated.
Regulation of glioblastoma multiforme stem-like cells by inhibitor of DNA binding proteins and oligodendroglial lineage-associated transcription factors.
GeneRIF
Xia et al., Baltimore, United States. In Cancer Sci, 2012
Id2 and Id4 regulated glioblastoma multiforme neurosphere differentiation through downregulating of another bHLH family member, the oligodendroglial lineage-associated transcription factors (Olig) 1 and 2
ID2: A negative transcription factor regulating oligodendroglia differentiation.
Review
Yao et al., Chongqing, China. In J Neurosci Res, 2012
ID4, another member of the ID family, functions similarly to ID2 in regulating the differentiation of OPC.
Type II arginine methyltransferase PRMT5 regulates gene expression of inhibitors of differentiation/DNA binding Id2 and Id4 during glial cell differentiation.
GeneRIF
Richard et al., Montréal, Canada. In J Biol Chem, 2012
CpG-rich islands within the Id2 and Id4 genes were bound by PRMT5 and were hypomethylated in PRMT5-deficient cells, suggesting that PRMT5 plays a role in gene silencing during glial cell
ID4 regulates mammary gland development by suppressing p38MAPK activity.
GeneRIF
Li et al., Houston, United States. In Development, 2011
ID4 promotes mammary gland development by suppressing p38MAPK activity.
Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats.
GeneRIF
Young et al., London, United Kingdom. In Plos One, 2011
Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients.
[ID4 promoter methylation in acute myeloid leukemia].
GeneRIF
Wang et al., Jinan, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011
Compared with ron deficiency anemia patients, ID4 gene methylation changes of different degrees occur in AML patients with different subtypes and stages.
Safety and immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with HIV-1: a randomized controlled trial.
Impact
ANRS HB03 VIHVAC-B Trial et al., Paris, France. In Jama, 2011
INTERVENTION: Patients were randomly assigned to receive 3 intramuscular injections of the standard dose (20 μg) of recombinant HBV vaccine at weeks 0, 4, and 24 (IM20 × 3 group, n = 145); 4 intramuscular double doses (40 μg [2 injections of 20 μg]) of recombinant HBV vaccine at weeks 0, 4, 8, and 24 (IM40 × 4 group, n = 148); or 4 intradermal injections of low doses (4 μg [1/5 of 20 μg]) of recombinant HBV vaccine at weeks 0, 4, 8, and 24 (ID4 × 4 group, n = 144).
Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia.
Impact
GeneRIF
Plass et al., Columbus, United States. In Nat Genet, 2005
identified Idb4 as a putative tumor-suppressor gene that is methylated in most mouse and human leukemias but in only a minority of other human cancers
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