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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dynein, axonemal, intermediate chain 1

The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, AGE, V1a
Papers on ICS
Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma.
Yamauchi et al., Chinju, South Korea. In Clin Exp Allergy, Feb 2016
OBJECTIVE: We determined the effects of high-dose inhaled corticosteroids (ICSs) on decreased pulmonary function in asthmatic Japanese patients with variants of IL13 and STAT4 during long-term treatments with low to mild doses of ICS.
Changing patterns of asthma medication use related to US Food and Drug Administration long-acting β2-agonist regulation from 2005-2011.
Baker et al., Hamilton, Bermuda. In J Allergy Clin Immunol, Jan 2016
RESULTS: When the 2005 regulatory activity was announced, there were statistically significant decreases in the use of fixed-dose ICS-LABA agents in children (-0.98 percentage points) and adults (-1.24 percentage points).
CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids.
Wu et al., Copenhagen, Denmark. In Immun Inflamm Dis, Dec 2015
Inhaled corticosteroids (ICS) are the most effective controller medications for asthma, and variability in ICS response is associated with genetic variation.
Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.
BELT Investigators et al., Boston, United States. In Jama, Nov 2015
OBJECTIVE: To compare the effectiveness and safety of tiotropium vs LABAs, when used with inhaled corticosteroids (ICS) in black adults with asthma and to determine whether allelic variation at the Arg16Gly locus of the β2-adrenergic receptor (ADRB2) geneis associated with treatment response.
Stepping down from inhaled corticosteroids with leukotriene inhibitors in asthma: a systematic review and meta-analysis.
Hagan et al., Scottsdale, United States. In Allergy Asthma Proc, May 2015
BACKGROUND: The risks of using leukotriene receptor antagonists (LTRA) as part of a strategy for stepping down inhaled corticosteroid (ICS) are not well known.
Fluticasone furoate/vilanterol: a review of its use in patients with asthma.
Syed, Auckland, New Zealand. In Drugs, Mar 2015
Fluticasone furoate/vilanterol (Relvar(®)) is a once-daily, fixed combination of an inhaled corticosteroid (ICS) and a long-acting β2-adrenoreceptor agonist (LABA), delivered via a dry powder inhaler (Ellipta(®)).
A re-evaluation of the role of inhaled corticosteroids in the management of patients with chronic obstructive pulmonary disease.
Price et al., Toronto, Canada. In Expert Opin Pharmacother, 2014
INTRODUCTION: Inhaled corticosteroids (ICS) (in fixed combinations with long-acting β2-agonists [LABAs]) are frequently prescribed for patients with chronic obstructive pulmonary disease (COPD), outside their labeled indications and recommended treatment strategies and guidelines, despite having the potential to cause significant side effects.
Development of schizogenous intercellular spaces in plants.
Ishizaki, Kōbe, Japan. In Front Plant Sci, 2014
In schizogenous ICS formation, specific molecular mechanisms regulate the sites of cell separation and coordinate extensive reorganization of cell walls.
Detecting Antigen-Specific T Cell Responses: From Bulk Populations to Single Cells.
Kelleher et al., Sydney, Australia. In Int J Mol Sci, 2014
Standard assays, such as the ICS, are often insufficient for characterization of rare subsets of cells.
Transcriptomic analysis of Camellia ptilophylla and identification of genes associated with flavonoid and caffeine biosynthesis.
Hang et al., Nanjing, China. In Genet Mol Res, 2014
NMT2 was highly identical to three orthologous genes TCS2, PCS2, and ICS2, which did not undergo methylation in vitro; in contrast, NMT1 was less identical to TCS, PCS and ICS, indicating that NMT1 may undergo neofunctionalization.
The Effects of Mechanically Deboned Chicken Hydrolysates on the Characteristics of Imitation Crab Stick.
Yang et al., Chinju, South Korea. In Korean J Food Sci Anim Resour, 2013
The effects of adding mechanically deboned chicken (MDC) hydrolysates on the quality characteristics of imitation crab stick (ICS) during storage were investigated.
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids.
Childhood Asthma Research and Education (CARE) Network of the National Heart et al., Madison, United States. In N Engl J Med, 2010
BACKGROUND: For children who have uncontrolled asthma despite the use of low-dose inhaled corticosteroids (ICS), evidence to guide step-up therapy is lacking.
Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD).
Witt et al., Poznań, Poland. In Respir Res, 2009
The worldwide involvement of DNAI1 mutations in PCD pathogenesis in families not preselected for ODA defects ranges from 7 to 10%.
Primary ciliary dyskinesia: improving the diagnostic approach.
Knowles et al., Chapel Hill, United States. In Curr Opin Pediatr, 2009
Two dynein genes, encoding ODA intermediate chain (DNAI1) and heavy chain (DNAH5), have been seen to be mutated in approximately 30-38% of the families
Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.
Foresta et al., Padova, Italy. In Hum Reprod, 2008
Male carriers of the mutations always exhibit asthenozoospermia, whereas female carriers manifest no alterations in either fertility or pulmonary clearance.
DNAI1 mutations explain only 2% of primary ciliary dykinesia.
Blouin et al., Genève, Switzerland. In Respiration, 2007
DNAI1 gene mutation is not a common cause of primary ciliary dyskinesia.
Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation.
Knowles et al., Chapel Hill, United States. In Am J Respir Crit Care Med, 2006
A total of 10% of patients with PCD are estimated to harbor mutations in DNAI1; most occur as a common founder IVS1+2_3insT or in exons 13, 16, and 17.
Isochorismate synthase is required to synthesize salicylic acid for plant defence.
Ausubel et al., Boston, United States. In Nature, 2001
Some bacteria such as Pseudomonas aeruginosa synthesize SA using isochorismate synthase (ICS) and pyruvate lyase.
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial.
Asthma Clinical Research Network for the National Heart et al., San Francisco, United States. In Jama, 2001
OBJECTIVE: To examine the effectiveness of salmeterol xinafoate, a long-acting beta(2)-agonist, as replacement therapy in patients whose asthma is well controlled by low-dose triamcinolone acetonide, an ICS.
Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation.
Wightman et al., Normal, United States. In Nature, 1999
One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically.
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