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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inducible T-cell co-stimulator

ICOS, H-4, SCIP, Oct-6, Tst-1
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD28, CD4, B7RP-1, CTLA-4, CAN
Papers using ICOS antibodies
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Supplier
Unutmaz Derya, In PLoS ONE, 2010
... -FITC (eBioscience, San Diego, USA), ICOS-PE (BD clone DX29, BD Biosciences, Oxford, UK) and IL-17A-APC-A ...
Papers on ICOS
A higher frequency of CD4(+)CXCR5(+) T follicular helper cells in patients with newly diagnosed Henoch-Schönlein purpura nephritis.
New
Jiang et al., Changchun, China. In Int Immunopharmacol, Feb 2016
The numbers of circulating CD4(+)CXCR5(+), CD4(+)CXCR5(+)ICOS(+) and CD4(+)CXCR5(+)PD-1(+) TFH cells, CD86(+)CD19(+), CD38(+)CD19(+) B cells and serum IL-2, IL-4, IL-17A, IL-21 and IFN-γ were significantly higher in HSPN patients (p<0.05)
Regulation of Immunity by Butyrophilins.
New
Impact
Trowsdale et al., Cambridge, United Kingdom. In Annu Rev Immunol, Feb 2016
They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276).
Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients.
New
Busse et al., Berlin, Germany. In Cancer Immunol Immunother, Feb 2016
Eomes expression correlated positively not only with expression of Tbx21 and TGFβ1 mRNA, but also with mRNA expression of the activation marker ICOS, and with in vivo activated HLA-DR(+) T cells.
Retrogenic ICOS Expression Increases Differentiation of KLRG-1hiCD127loCD8+ T Cells during Listeria Infection and Diminishes Recall Responses.
New
Ford et al., Atlanta, United States. In J Immunol, Feb 2016
The ICOS is not expressed on resting T cells but is rapidly upregulated upon encounter with Ag.
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease.
Review
New
Doherty et al., San Diego, United States. In Curr Allergy Asthma Rep, Jan 2016
In addition, ILC2 function is also influenced by inducible T cell costimulator (ICOS)/ICOS-ligand (ICOS-L) interactions via direct contact between immune cells.
Transcriptional regulation of mouse hypoglossal motor neuron somatotopic map formation.
New
Stifani et al., Montréal, Canada. In Brain Struct Funct, Jan 2016
Here we show that combinatorial expression of transcription factors Runx1, SCIP and FoxP1 defines separate mouse hypoglossal motor neuron groups with different topological, neurotransmitter and calcium-buffering phenotypes.
[Dynamic alteration of CD154/CD40 and its effects on Th1/Th2 polarization in inducible co-stimulator ligand knockout mice infected with Schistosoma japonicum].
New
Xia et al., Huainan, China. In Beijing Da Xue Xue Bao, Jan 2016
OBJECTIVE: To analyze effect on the CD154-CD40 signaling pathway and Th1/Th2 polarization by deficient inducible co-stimulator (ICOS)-ICOS ligand (ICOSL) signaling in mice infected with Schistosoma japonicum.
Integrated molecular analysis of adult T cell leukemia/lymphoma.
New
Impact
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
Other notable features include a predominance of activating mutations (in PLCG1, PRKCB, CARD11, VAV1, IRF4, FYN, CCR4 and CCR7) and gene fusions (CTLA4-CD28 and ICOS-CD28).
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
New
Impact
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Second, they promoted early T(FH) differentiation via the multipronged approach of sustaining expression of the cytokine receptors IL-6Rα and gp130, enhancing expression of the costimulatory receptor ICOS and promoting expression of the transcriptional repressor Bcl6.
Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS.
Review
New
Melero et al., Pamplona, Spain. In Semin Oncol, Aug 2015
Co-stimulatory receptors include surface moieties that are constitutively expressed on resting lymphocytes such as CD28 or CD27 and others whose expression is induced upon recent previous antigen priming, ie, CD137, GITR, OX40, and ICOS.
Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor.
Review
New
De Silva et al., Colombo, Sri Lanka. In Int J Immunogenet, Aug 2015
However, a number of distinct genetic defects including in inducible co-stimulator (ICOS), B-cell-activating factor receptor (BAFFR) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) have been identified in a minority of patients with CVID.
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
New
Impact
Locksley et al., San Francisco, United States. In Immunity, Aug 2015
Unexpectedly, ILC2-intrinsic IL-33 activation was required for Treg cell accumulation in vivo and was independent of ILC2 type 2 cytokines but partially dependent on direct co-stimulatory interactions via ICOSL-ICOS.
OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.
New
Impact
Blanco et al., Bordeaux, France. In Immunity, Jul 2015
The frequency of circulating OX40L-expressing myeloid APCs positively correlated with disease activity and the frequency of ICOS(+) blood Tfh cells in SLE.
[Immunological Aspects in Oncology--Circulating γδ T Cells].
Review
Dubská et al., In Klin Onkol, 2014
Detailed immunophenotyping was also conducted describing representation of memory subsets (using CD45RO and CD27 markers) and presence of surface markers HLADr, CD69, CD25, CD28, CCR7, CTLA 4, ICOS, PD 1L and PD 1 between γδ T cells of the controls and breast carcinoma patients.
Follicular Helper CD4+ T Cells in Human Neuroautoimmune Diseases and Their Animal Models.
Review
Jin et al., Jilin, China. In Mediators Inflamm, 2014
TFH cells can be identified by a combination of markers, including the chemokine receptor CXCR5, costimulatory molecules ICOS and PD-1, transcription repressor Bcl-6, and cytokine IL-21.
ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance.
GeneRIF
Hansen et al., Hannover, Germany. In J Immunol, 2012
Our findings demonstrate a crucial role of ICOS for the generation and suppressive function of Tregs conveying respiratory tolerance
Association of genetic variation in co-stimulatory molecule genes with outcome of liver transplant in Iranian patients.
GeneRIF
Nikeghbalian et al., Shīrāz, Iran. In Gene, 2012
Genetic variation in ICOS gene is associated with acute rejection of liver transplantation.
Comprehensive analysis of CD4+ T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS.
GeneRIF
Kroczek et al., Berlin, Germany. In J Immunol, 2012
Through a newly identified role for T effector cell/Treg (regulatory T) cell balance, together with its established function in the B cell immune system, ICOS emerges as a central mediator of adaptive immunity.
AP-1 is involved in ICOS gene expression downstream of TCR/CD28 and cytokine receptor signaling.
GeneRIF
Abe et al., Noda, Japan. In Eur J Immunol, 2012
Results indicate AP-1 transcription factors are involved in ICOS gene expression downstream of both TCR/CD28 signaling and cytokine receptor signaling.
Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage.
GeneRIF
Celetti et al., Napoli, Italy. In Plos One, 2011
Following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry.
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