Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide.
New Haven, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013
Integrin cytoplasmic domain-associated protein-1 (ICAP1) is a suppressor of integrin activation and directly binds to the cytoplasmic tail of β1 integrins; its binding suppresses integrin activation by competition with talin.
New insights into Nm23 control of cell adhesion and migration.
Grenoble, France. In J Bioenerg Biomembr, 2003
Finally, the recent discovery of the interaction between Nm23-H2 and the negative regulator of beta1 integrin-mediated cell adhesion, ICAP-1, which targets the kinase to lamellipodia and cell protrusions, suggests that the Nm23-H2/ICAP-1 complex plays a role in integrin signaling, and exerts a fine-tuning between migration and spreading.