gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Acyl-CoA dehydrogenase family, member 8

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, AGE
Papers on IBD
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo.
Neufert et al., Erlangen, Germany. In Gut, Feb 2016
RESULTS: Expression of IL-36α and IL-36γ was significantly elevated in active human IBD and experimental colitis.
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease.
Sugimoto et al., In Digestion, Feb 2016
However, bacterial species that characterize dysbiosis in IBD remain unclear.
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
Watanabe et al., In Digestion, Feb 2016
UNASSIGNED: Prolonged inflammatory bowel diseases (IBD) may lead to colitis-associated carcinogenesis (CAC).
Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health.
Gahan et al., Cork, Ireland. In Annu Rev Food Sci Technol, Feb 2016
Alterations to the gut microbiota that influence bile acid metabolism are associated with metabolic disease, obesity, diarrhea, inflammatory bowel disease (IBD), Clostridium difficile infection, colorectal cancer, and hepatocellular carcinoma.
Inflammatory bowel disease: can omega-3 fatty acids really help?
de Carvalho et al., Marília, Brazil. In Ann Gastroenterol, Jan 2016
Adjuvants to the traditional therapy of inflammatory bowel disease (IBD) have been studied to enhance the efficacy of the treatment and improve patients' quality of life.
The role of the calcium-sensing receptor in gastrointestinal inflammation.
Mohamadzadeh et al., Gainesville, United States. In Semin Cell Dev Biol, Jan 2016
These findings suggest that pharmacologic CaSR activators and CaSR-based nutrients such as calcium, polyamines, phenylalanine, tryptophan, and oligo-peptides might be useful in conditioning the gut microenvironment, and thus, in the prevention and treatment of disorders such as inflammatory bowel disease (IBD), infectious enterocolitis, and other inflammatory and secretory diarrheal diseases.
An integrative analysis of gene expression and molecular interaction data to identify dys-regulated sub-networks in inflammatory bowel disease.
Simmons et al., Oxford, United Kingdom. In Bmc Bioinformatics, Dec 2015
BACKGROUND: Inflammatory bowel disease (IBD) consists of two main disease-subtypes, Crohn's disease (CD) and ulcerative colitis (UC); these subtypes share overlapping genetic and clinical features.
Commensal bacteria direct selective cargo sorting to promote symbiosis.
Liu et al., Beijing, China. In Nat Immunol, Sep 2015
Here we report that in mice symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2, a cytosolic bacterial sensor, and the multifunctional protein kinase LRRK2, both encoded by inflammatory bowel disease (IBD)-associated genes.
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.
Sonnenberg et al., New York City, United States. In Science, Jun 2015
Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively.
TNFα inhibitor induced lupus-like syndrome (TAILS) in a patient with IBD.
Diculescu et al., Bucureşti, Romania. In Curr Health Sci J, 2014
BACKGROUND: In patients with autoimmune diseases like inflammatory bowel diseases there has been reported a drug-induced lupus like syndrome secondary to TNFα inhibitors.
Colorectal Cancer in Inflammatory Bowel Disease: Epidemiology, Pathogenesis and Surveillance.
Fang et al., Shanghai, China. In Gastrointest Tumors, 2014
BACKGROUND: Inflammatory bowel disease (IBD; including ulcerative colitis and Crohn's disease) is associated with an increased risk for colorectal cancer (CRC).
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
Abraham et al., New Haven, United States. In Immunity, 2014
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune homeostasis and cytokine secretion.
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
van Lookeren Campagne et al., San Francisco, United States. In Nature, 2014
Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract.
Features of intestinal lesions in the clinical course of inflammatory bowel diseases.
Sferra et al., In Ital J Anat Embryol, 2013
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic, progressive and relapsing inflammatory disorders of unknown etiology.
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.
Jung et al., Israel. In Immunity, 2013
Collectively, our results highlight cellular dynamics in the inflamed colon and the plasticity of Ly6C(hi) monocytes, marking them as potential targets for inflammatory bowel disease (IBD) therapy.
Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans.
Vockley et al., Rochester, United States. In Mol Genet Metab, 2002
first enzymatic and molecular confirmation of a deficiency of this enzyme in a patient
share on facebooktweetadd +1mail to friends