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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Acyl-CoA dehydrogenase family, member 8

IBD
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, AGE
Papers on IBD
IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo.
New
Neufert et al., Erlangen, Germany. In Gut, Feb 2016
RESULTS: Expression of IL-36α and IL-36γ was significantly elevated in active human IBD and experimental colitis.
The impact of genetic factors on response to glucocorticoids therapy in IBD.
Review
New
Dobrowolska et al., Poznań, Poland. In Scand J Gastroenterol, Feb 2016
UNASSIGNED: Glucocorticosteroids (GCs) are used for many years as first-line drugs for the achievement of remission in exacerbations of inflammatory bowel disease (IBD).
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
Review
New
Watanabe et al., In Digestion, Feb 2016
UNASSIGNED: Prolonged inflammatory bowel diseases (IBD) may lead to colitis-associated carcinogenesis (CAC).
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease.
New
Sugimoto et al., In Digestion, Feb 2016
However, bacterial species that characterize dysbiosis in IBD remain unclear.
Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health.
Review
New
Gahan et al., Cork, Ireland. In Annu Rev Food Sci Technol, Feb 2016
Alterations to the gut microbiota that influence bile acid metabolism are associated with metabolic disease, obesity, diarrhea, inflammatory bowel disease (IBD), Clostridium difficile infection, colorectal cancer, and hepatocellular carcinoma.
Inflammatory bowel disease: can omega-3 fatty acids really help?
Review
New
de Carvalho et al., Marília, Brazil. In Ann Gastroenterol, Jan 2016
Adjuvants to the traditional therapy of inflammatory bowel disease (IBD) have been studied to enhance the efficacy of the treatment and improve patients' quality of life.
An integrative analysis of gene expression and molecular interaction data to identify dys-regulated sub-networks in inflammatory bowel disease.
New
Simmons et al., Oxford, United Kingdom. In Bmc Bioinformatics, Dec 2015
BACKGROUND: Inflammatory bowel disease (IBD) consists of two main disease-subtypes, Crohn's disease (CD) and ulcerative colitis (UC); these subtypes share overlapping genetic and clinical features.
Commensal bacteria direct selective cargo sorting to promote symbiosis.
New
Impact
Liu et al., Beijing, China. In Nat Immunol, Sep 2015
Here we report that in mice symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2, a cytosolic bacterial sensor, and the multifunctional protein kinase LRRK2, both encoded by inflammatory bowel disease (IBD)-associated genes.
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.
New
Impact
Sonnenberg et al., New York City, United States. In Science, Jun 2015
Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively.
TNFα inhibitor induced lupus-like syndrome (TAILS) in a patient with IBD.
Diculescu et al., Bucureşti, Romania. In Curr Health Sci J, 2014
BACKGROUND: In patients with autoimmune diseases like inflammatory bowel diseases there has been reported a drug-induced lupus like syndrome secondary to TNFα inhibitors.
Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.
Impact
Abraham et al., New Haven, United States. In Immunity, 2014
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune homeostasis and cytokine secretion.
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
Impact
van Lookeren Campagne et al., San Francisco, United States. In Nature, 2014
Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract.
Features of intestinal lesions in the clinical course of inflammatory bowel diseases.
Review
Sferra et al., In Ital J Anat Embryol, 2013
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic, progressive and relapsing inflammatory disorders of unknown etiology.
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells.
Impact
Jung et al., Israel. In Immunity, 2013
Collectively, our results highlight cellular dynamics in the inflamed colon and the plasticity of Ly6C(hi) monocytes, marking them as potential targets for inflammatory bowel disease (IBD) therapy.
Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo Functional Properties.
Ignacimuthu et al., Chennai, India. In Probiotics Antimicrob Proteins, 2011
Our study reports the use of B. amyloliquefaciens isolated from Himalayan soil as probiotic and its beneficial effect on IBD for the first time and suggests that this could be used as potential probiotics in functional foods or as a curative agent.
Identification of isobutyryl-CoA dehydrogenase and its deficiency in humans.
GeneRIF
Vockley et al., Rochester, United States. In Mol Genet Metab, 2002
first enzymatic and molecular confirmation of a deficiency of this enzyme in a patient
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