The role of the calcium-sensing receptor in gastrointestinal inflammation.
Gainesville, United States. In Semin Cell Dev Biol, Jan 2016
These findings suggest that pharmacologic CaSR activators and CaSR-based nutrients such as calcium, polyamines, phenylalanine, tryptophan, and oligo-peptides might be useful in conditioning the gut microenvironment, and thus, in the prevention and treatment of disorders such as inflammatory bowel disease (IBD), infectious enterocolitis, and other inflammatory and secretory diarrheal diseases.
Commensal bacteria direct selective cargo sorting to promote symbiosis.
Beijing, China. In Nat Immunol, Sep 2015
Here we report that in mice symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2, a cytosolic bacterial sensor, and the multifunctional protein kinase LRRK2, both encoded by inflammatory bowel disease (IBD)-associated genes.