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Baculoviral IAP repeat-containing 3

IAP-1
may be involved in inhibition of apoptosis [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PrP, XIAP, bcl-2, NF-kappaB, caspase-3
Papers on IAP-1
α-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation.
New
Hortelano et al., Madrid, Spain. In Toxicol Appl Pharmacol, Sep 2015
α-H induced activation of caspase-8 and caspase-9 and also increased levels of the proapoptotic protein Bax, decreasing antiapoptotic proteins (Bcl-2, X-IAP and IAP-1) in HepG2 cells.
Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets.
Pal et al., New Delhi, India. In Bmc Cancer, 2014
The hormone increased the transcription and/or expression of molecular intermediates (SURVIVIN, HIF-1α, PARP-1, Bcl-2, c-FLIP, KLK-10, XIAP, c-IAP-1) associated with chemo-resistance and increased levels of stress modulators (PON2, HO-1, HSP27 and NRF-2).
Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells.
Ahn et al., Seoul, South Korea. In Cancer Lett, 2014
BGM also downregulated the expression of STAT3-regulated gene products such as COX-2, VEGF, cyclin D1, survivin, IAP-1, Bcl-2, and Bcl-xl in MM cells.
Piperlongumine chemosensitizes tumor cells through interaction with cysteine 179 of IκBα kinase, leading to suppression of NF-κB-regulated gene products.
Aggarwal et al., Beijing, China. In Mol Cancer Ther, 2014
Inhibition in NF-κB activity downregulated the expression of proteins involved in cell survival (Bcl-2, Bcl-xL, c-IAP-1, c-IAP-2, survivin), proliferation (c-Myc, cyclin D1), inflammation (COX-2, IL6), and invasion (ICAM-1, -9, CXCR-4, VEGF).
RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway.
Wu et al., Harbin, China. In Oncol Rep, 2014
There was no effect on the gene transcription of c-IAP-1, c-IAP-2, and x-linked IAP (XIAP) compared with the control group, whereas mRNA levels of survivin and the neuronal apoptosis inhibitory protein (NAIP) markedly decreased.
Single-stranded DNA fragments of insect-specific nuclear polyhedrosis virus act as selective DNA insecticides for gypsy moth control.
Skorokhod et al., Simferopol', Ukraine. In Pestic Biochem Physiol, 2014
Part of the gypsy moth genome cloned with the fragments of BIR and RING domains of LdMNPV IAP-3 gene as primers, has an overlap with the corresponding part of the LdMNPV IAP-3 gene and L.dispar IAP-1 mRNA for an inhibitor of apoptosis protein with the high cover by query, allows assuming that we cloned a part of gypsy moth anti-apoptosis gene.
Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice.
Aichele et al., In Blood, 2014
The profound negative effect of IAP antagonists on T-cell immunity was partially linked to tumor necrosis factor-mediated cell death of activated T cells and required inhibition of X-linked inhibitor of apoptosis, as well as cellular IAP-1.
Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells.
Choi et al., Pusan, South Korea. In Food Chem Toxicol, 2013
Allium cepa Linn is commonly used as supplementary folk remedy for cancer therapy.
Screening of candidate proteins interacting with IE-2 of Bombyx mori nucleopolyhedrovirus.
Wang et al., In Mol Biol Rep, 2013
Of several isolated protein components, sixteen candidates were identified by MALDI-TOF mass-spectrometry, eight baculoviral proteins (ALK-EXO, F protein, IAP-1, LEF-3, LEF-9, ODV-NC42, TLP, and VP39), and eight proteins from B. mori (Actin, ADP/ATP translocase, ATP synthase subunit beta, Beta-tubulin, DNA topoisomerase 2, Histone H4, Soluble guanylyl cyclae alpha-1 subunit, Transketolase).
Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma.
Vander et al., Tel Aviv-Yafo, Israel. In Mol Vis, 2012
The expression patterns of the prosurvival genes IAP-1 and XIAP differed between retinas and ONs of glaucomatous eyes: Both were upregulated in the retinas, but XIAP was downregulated in the ONs, while IAP-1 stayed unchanged.
Increase in retinal ganglion cells' susceptibility to elevated intraocular pressure and impairment of their endogenous neuroprotective mechanism by age.
Lavinsky et al., Tel Aviv-Yafo, Israel. In Mol Vis, 2012
The two important prosurvival genes, IAP-1 and X-linked IAP (XIAP), acted in opposite directions in 3-month-old and 15-month-old rats, and were significantly decreased in aged glaucomatous retinas, while their expression increased significantly in young glaucomatous eyes.
Flt-1 expression influences apoptotic susceptibility of vascular smooth muscle cells through the NF-kappaB/IAP-1 pathway.
GeneRIF
Spagnoli et al., Roma, Italy. In Cardiovasc Res, 2010
Flt-1 expression influences apoptotic susceptibility of vascular smooth muscle cells through the NF-kappaB/IAP-1 pathway.
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.
Impact
Rajalingam et al., Frankfurt am Main, Germany. In Nat Cell Biol, 2008
In addition, XIAP or c-IAP-1/2 knockdown cells showed enhanced cell migration in a C-RAF-dependent manner.
Regulation of apoptosis in Drosophila.
Review
Steller, New York City, United States. In Cell Death Differ, 2008
Drosophila IAP-1 (Diap1) functions as an E3-ubiquitin ligase to protect cells from unwanted death by promoting the degradation of the initiator caspase Dronc.
Characterization of cancer stem cells in chronic myeloid leukaemia.
Review
Holyoake et al., Glasgow, United Kingdom. In Biochem Soc Trans, 2007
In association with apoptosis, there is activation of caspase 8 and caspase 3, inhibition of the MAPK pathway, IAP-1 (inhibitor of apoptosis protein-1), NF-kappaB (nuclear factor kappaB) and iNOS (inducible nitric oxide synthase).
The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis.
GeneRIF
Toppari et al., Turku, Finland. In Mol Cell Endocrinol, 2006
expression of IAP1 & IAP2 show different cycles throughout the seminiferous epithelial cycle of the testis; the cellular distribution of these proteins is also different; results illustrate the role IAPs play in the regulation of spermatogenic apoptosis
ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.
GeneRIF
Rosen et al., Halifax, Canada. In J Biol Chem, 2005
It is reported report that ras oncogene, an established inhibitor of anoikis, triggers a significant upregulation of anti-apoptotic proteins cIAP2 and XIAP in intestinal epithelial cells.
Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia.
GeneRIF
Lee et al., South Korea. In Neuroreport, 2003
decrease in IAP-1 expression by TGF-beta1 might provide an important regulatory function in TGF-beta1-mediated microglial death and in attenuation of excessive microglial activation in pathological conditions.
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.
Impact
Zlokovic et al., Rochester, United States. In Nat Med, 2003
These mechanisms are distinct from those involving upregulation of the genes encoding the anti-apoptotic Bcl-2 homolog A1 and inhibitor of apoptosis protein-1 (IAP-1) by APC in umbilical vein endothelial cells.
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