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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein tyrosine phosphatase, receptor type, N

IA-2, ICA512
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Insulin, HAD, AGE, ACID, Glutamate Decarboxylase
Papers on IA-2
Risk of Parametrial Spread in Small Stage I Cervical Carcinoma: Pathology Review of 223 Cases With a Tumor Diameter of 20 mm or Less.
New
Kesic et al., Belgrade, Serbia. In Int J Gynecol Cancer, Feb 2016
METHODS: Pathology review was done on patients with stages IA2 and small IB1, treated by radical hysterectomy and pelvic lymph node dissection.
Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes.
New
Better Diabetes Diagnosis (BDD) Study Group et al., Malmö, Sweden. In Diabetes, Feb 2016
UNASSIGNED: The possible contribution of HLA-DRB3, -DRB4 and -DRB5 alleles to type 1 diabetes risk and to autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 against either of the three amino acid variants, R, W or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear.
Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.
New
Roep et al., Leiden, Netherlands. In Diabetes, Jan 2016
To dissect the role of HLA-DQ8trans in presenting natural islet epitopes, we analyzed the islet peptidome of HLA-DQ2, DQ8 and DQ2/8 by pulsing DC with preproinsulin (PPI), IA-2 and GAD65.
Early stage cervical cancer: Brachytherapy followed by type a hysterectomy versus type B radical hysterectomy alone, a retrospective evaluation.
New
Lambaudie et al., Limoges, France. In Eur J Surg Oncol, Jan 2016
MATERIALS AND METHODS: It is a retrospective and collaborative study between the Paoli Calmettes Institute (Marseille) and the Oscar Lambret Center (Lille) from 2001 to 2013, in patients with tumors FIGO stages IA1, IA2, IB1 and IIA less than 2 cm of diameter, without pelvic lymph node involvement.
The sentinel node procedure in early stage cervical cancer, taking the next step; a diagnostic review.
Review
New
Bekkers et al., Nijmegen, Netherlands. In Gynecol Oncol, Dec 2015
Prerequisites such as early FIGO stage (IA2, IB1, IIA primary tumor size <40mm), no suspicious pre-, and per-operative lymph nodes, and bilateral negative SLNs after ultra staging resulted in 1 remaining false negative result among 1257 patients (0.08%).
Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity.
Review
New
Pugliese et al., Miami, United States. In Curr Diab Rep, Dec 2015
T1DR is typically characterized by (1) variable degree of insulitis and loss of insulin staining, on pancreas transplant biopsy (with most often absent), minimal to moderate and rarely severe pancreas, and/or kidney transplant rejection; (2) the conversion of T1D-associated autoantibodies (to the autoantigens GAD65, IA-2, and ZnT8), preceding hyperglycemia by a variable length of time; and (3) the presence of autoreactive T cells in the peripheral blood, pancreas transplant, and/or peripancreatic transplant lymph nodes.
AGE-RAGE signal generates a specific NF-κB RelA "barcode" that directs collagen I expression.
New
Lin et al., Baltimore, United States. In Sci Rep, Dec 2015
In the current study, we established that AGE-RAGE signaling results in NF-κB activation that directs collagen Ia1 and Ia2 expression.
Minimization of curative surgery for treatment of early cervical cancer: a review.
Review
New
Gynecologic Cancer Study Group of the Japan Clinical Oncology Group et al., Kyoto, Japan. In Jpn J Clin Oncol, Jul 2015
The use of modified radical hysterectomy may not only be curative but also minimally invasive for Stage IA2-IB1 patients with a tumor size <2 cm in diameter.
Emergencies in Childhood Diabetes
Review
New
Maclaren, Madagascar. In Unknown Journal, May 2015
T2DM is a strongly genetic disease that results from insulin resistance, not insulin deficiency as in T1DM, and it is not associated with antibodies against the pancreatic β cells (GAD and IA-2 and insulin types) that typify T1DM.
Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial.
Impact
TRIGR Study Group et al., Helsinki, Finland. In Jama, 2014
Autoantibodies to insulin, glutamic acid decarboxylase, and the insulinoma-associated-2 (IA-2) molecule were analyzed using radiobinding assays and islet cell antibodies with immunofluorescence during a median observation period of 7.0 years (mean, 6.3 years).
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.
Impact
Eisenbarth et al., München, Germany. In Jama, 2013
DESIGN, SETTING, AND PARTICIPANTS: Data were pooled from prospective cohort studies performed in Colorado (recruitment, 1993-2006), Finland (recruitment, 1994-2009), and Germany (recruitment, 1989-2006) examining children genetically at risk for type 1 diabetes for the development of insulin autoantibodies, glutamic acid decarboxylase 65 (GAD65) autoantibodies, insulinoma antigen 2 (IA2) autoantibodies, and diabetes.
Lack of anti-insulin, anti-GAD, and anti-IA2 autoantibodies in primary antiphospholipid syndrome.
GeneRIF
Caleiro et al., In Rheumatol Int, 2012
Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome.
Zinc transporter 8 autoantibodies increase the predictive value of islet autoantibodies for function loss of technically successful solitary pancreas transplant.
GeneRIF
Bosi et al., Pisa, Italy. In Transplantation, 2011
ZnT8A, GADA and IA-2A are autoantibodies that may have a role in successful pancreas graft survival
Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.
GeneRIF
T1DGC6 et al., Las Palmas de Gran Canaria, Spain. In Diabetes Metab Res Rev, 2011
In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies
Pearls in autoimmunity.
Review
Shoenfeld et al., São Paulo, Brazil. In Auto Immun Highlights, 2011
(2) Type 1 diabetes and genetic discovers, studies with GAD 65 and IA-2 autoantigen and the association T1D and autoimmune organ-specific diseases.
Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles.
GeneRIF
Wagner et al., Aachen, Germany. In Oncology, 2010
Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C).
Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.
GeneRIF
Ermácora et al., Buenos Aires, Argentina. In Plos One, 2010
analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain
Dietary intervention in infancy and later signs of beta-cell autoimmunity.
Impact
Finnish TRIGR Study Group et al., Helsinki, Finland. In N Engl J Med, 2010
Autoantibodies to insulin, glutamic acid decarboxylase (GAD), the insulinoma-associated 2 molecule (IA-2), and zinc transporter 8 were analyzed with the use of radiobinding assays, and islet-cell antibodies were analyzed with the use of immunofluorescence, during a median observation period of 10 years (mean, 7.5).
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.
Impact
GeneRIF
Solimena et al., Dresden, Germany. In Nat Cell Biol, 2006
The cleaved cytosolic fragment of ICA512 enhances the transcription of secretory granule genes (including its own gene) by binding to tyrosine phosphorylated signal transducers and activators of transcription (STAT) 5 and preventing its dephosphorylation.
Low value of [18F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy.
Impact
Lai et al., Taiwan. In J Clin Oncol, 2006
PATIENTS AND METHODS: Patients with untreated stage IA2 to IIA adenocarcinoma (AD) or adenosquamous carcinoma (ASC) or nonbulky (< or = 4 cm) squamous cell carcinoma cervical cancer with magnetic resonance imaging (MRI) -defined negative nodal metastasis were enrolled onto a prospective study with a two-stage design.
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