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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Conserved helix-loop-helix ubiquitous kinase

I-kappa B Kinase, IKKalpha
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NF-kappaB, IKKbeta, IkappaBalpha, p65, V1a
Papers using I-kappa B Kinase antibodies
Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NFκB
Supplier
Chang Alice Y. W., In PLoS ONE, 2003
... Bay 11-7082, a selective IkappaB kinase (IKK) inhibitor was obtained from Cayman Chemical (Ann Arbor, MI) ...
Papers on I-kappa B Kinase
Platelet Activating Factor (PAF): A Role in Preterm Delivery and an Essential Interaction with Toll-Like Receptor (TLR) Signaling in Mice.
New
Hirsch et al., In Biol Reprod, 24 Oct 2014
In peritoneal macrophages the PTAFR agonist cPAF induces production of inflammatory markers previously demonstrated to be up-regulated during bacterially induced labor, including: inducible nitric oxide synthase (Nos2), the chemokine Ccl5 (RANTES), tumor necrosis factor (Tnf) and level of their end-products (NO, CCL5, TNF) in a process dependent upon both IkappaB kinase and calcium/calmodulin-dependent protein kinase (CaMK) II.
Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.
New
Pham et al., Saint Louis, United States. In Acs Nano, Aug 2014
Autophagy in turn mediates the degradation of IkappaB kinase (IKK), suppressing the NF-κB p65 signaling pathway and inflammatory cytokine release.
Spatial control of bone formation using a porous polymer scaffold co-delivering anabolic rhBMP-2 and anti-resorptive agents.
New
Schindeler et al., Westmead, Australia. In Eur Cell Mater, Dec 2013
Scaffolds were encapsulated with anabolic rhBMP-2 (20 µg) ± anti-resorptive agents: zoledronic acid (5 µg ZA), ZA pre-adsorbed onto hydroxyapatite microparticles, (5 µg ZA/2% HA) or IkappaB kinase (IKK) inhibitor (10 µg PS-1145).
A20-mediated negative regulation of canonical NF-κB signaling pathway.
Review
New
Shembade et al., Miami, United States. In Immunol Res, Dec 2013
All known NF-κB activators converge on the IkappaB kinase (IKK) complex to activate the canonical and non-canonical NF-κB pathways.
Hepatic tissue environment in NEMO-deficient mice critically regulates positive selection of donor cells after hepatocyte transplantation.
New
Streetz et al., Aachen, Germany. In Plos One, Dec 2013
The deletion of the I-kappa B kinase-regulatory subunit IKKγ/NEMO in hepatocytes prevents nuclear factor (NF)-kB activation and triggers spontaneous liver apoptosis, chronic hepatitis and the development of liver fibrosis and hepatocellular carcinoma.
Inhibition and enhancement of contextual fear memory destabilization.
New
Flavell et al., Birmingham, United Kingdom. In Front Behav Neurosci, Dec 2013
Co-infusion of ACEA and the IkappaB kinase (IKK) inhibitor sulfasalazine (Sulf) into the dorsal hippocampus impaired contextual fear memory reconsolidation.
Increase in IkappaB kinase alpha expression suppresses the tumor progression and improves the prognosis for nasopharyngeal carcinoma.
New
Chen et al., Chengdu, China. In Mol Carcinog, Oct 2013
UNLABELLED: Recent studies have suggested that the action of IkappaB kinase alpha (IKKα) as a tumor suppressor is crucial in the development of skin carcinoma, but its role in nasopharyngeal carcinoma (NPC) remains unknown.
HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA.
GeneRIF
Giam et al., Bethesda, United States. In J Virol, 2012
HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-kappaB and depends on chronically activated IKKalpha and RelA.
A role for the NF-κB pathway in cell protection from complement-dependent cytotoxicity.
GeneRIF
Fishelson et al., Tel Aviv-Yafo, Israel. In J Immunol, 2012
Embryonic fibroblasts lacking either the p65 subunit of NF-kappaB or the IkappaB kinase alpha or IkappaB beta subunits of the NF-kappaB activator complex are more sensitive to complement-dependent cytotoxicity.
IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling.
GeneRIF
Abbott et al., Cleveland, United States. In Mol Cell Biol, 2012
Like IKKalpha, TRAF4 is atypical within its family because it is the only TRAF family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation.
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.
Impact
GeneRIF
Qian et al., Shanghai, China. In Nat Med, 2012
MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha.
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
GeneRIF
Hu et al., Frederick, United States. In Blood, 2012
This study found defective bone marrow B-cell development and increased myeloid-erythroid lineages in kinase-dead IKK alpha (KA/KA) knock-in mice.
The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer.
Review
Trautwein et al., Aachen, Germany. In Eur J Cell Biol, 2012
By using conditional knockout technology in mice we genetically dissected the I-kappa B kinase (IKK) complex consisting of IKK1/IKKα, IKK2/IKKβ and IKKγ/NEMO.
[Research progress of the biological characteristics of IkappaB kinase and its inhibitors].
Review
Wu et al., Chaohu, China. In Yao Xue Xue Bao, 2011
IkappaB kinase (IKK) is the key of this pathway, and it owns a special structure which consists of catalytic subunit and regulatory subunit.
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
Impact
GeneRIF
Liu et al., Bethesda, United States. In Nat Immunol, 2010
during human monocyte-macrophage differentiation, expression of the microRNAs miR-223, miR-15a and miR-16 decreased considerably, which led to higher expression of the serine-threonine kinase IKKalpha in macrophages
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
Impact
Spiegel et al., Richmond, United States. In Nature, 2010
Genetic evidence indicates that TRAF2 is necessary for the polyubiquitination of receptor interacting protein 1 (RIP1) that then serves as a platform for recruitment and stimulation of IkappaB kinase, leading to activation of the transcription factor NF-kappaB.
Oncogenic activation of NF-kappaB.
Review
Staudt, Bethesda, United States. In Cold Spring Harb Perspect Biol, 2010
Many genetic aberrations in lymphomas alter CARD11, MALT1, or BCL10, which constitute a signaling complex that is intermediate between the B-cell receptor and IkappaB kinase.
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Impact
Wang et al., Houston, United States. In Cell, 2010
NLRC5 inhibited NF-kappaB-dependent responses by interacting with IKKalpha and IKKbeta and blocking their phosphorylation.
NF-kappaB signaling: a tale of two pathways in skeletal myogenesis.
Review
Impact
Guttridge et al., Columbus, United States. In Physiol Rev, 2010
Activation of NF-kappaB is controlled by an IkappaB kinase (IKK) complex that can direct either canonical (classical) NF-kappaB signaling by degrading the IkappaB inhibitor and releasing p65/p50 dimers to the nucleus, or causes p100 processing and nuclear translocation of RelB/p52 via a noncanonical (alternative) pathway.
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer.
Impact
Karin et al., San Diego, United States. In Nature, 2010
The inflammation-responsive IkappaB kinase (IKK)-beta and its target NF-kappaB have important tumour-promoting functions within malignant cells and inflammatory cells.
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