hypoxia-inducible factor 1alpha
Expression and significance of HIF-1α and HIF-2α in pancreatic cancer.
Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, Dec 2015
The expression levels of hypoxia-inducible factor 1alpha (HIF-1α) and HIF-2α in pancreatic cancer (PC) and their association with clinicopathologic characteristics were investigated in order to elucidate their roles in the development of PC.
Thyroid hormone and angiogenesis.
Albany, United States. In Vascul Pharmacol, 2010
The hormone may also induce expression of the hypoxia-inducible factor 1alpha (HIF1alpha) gene, a transcription factor important to coronary artery collateralization in the setting of hypoxia.
Oxygen sensing in the carotid body.
Sevilla, Spain. In Ann N Y Acad Sci, 2009
We discuss here the role in CB oxygen sensing of the hypoxia-inducible factor 1alpha, the mitochondrial complex II subunit D, and heme oxygenase 2. In chronic hypoxia the CB grows with increase in glomus cell number.
Molecular mechanisms of thrombopoietin signaling.
San Diego, United States. In J Thromb Haemost, 2009
Additional signals activated by these secondary mediators include mammalian target of rapamycin, beta-catenin, hypoxia-inducible factor 1alpha and the homeobox proteins HOXB4 and HOXA9, and a number that are reduced, including glycogen synthase kinase 3alpha and the FOXO3 family of forkhead proteins.
Phosphorylated ERalpha, HIF-1alpha, and MAPK signaling as predictors of primary endocrine treatment response and resistance in patients with breast cancer.
Oxford, United Kingdom. In J Clin Oncol, 2009
Twenty-four tumor proteins involved in apoptosis, cell survival, hypoxia, angiogenesis, growth factor, and hormone signaling were assessed by immunohistochemistry in pretreatment samples (eg, caspase 3, phospho- mammalian target of rapamycin, hypoxia-inducible factor 1alpha [HIF-1alpha], vascular endothelial growth factor, mitogen-activated protein kinase [MAPK], phosphorylated epidermal growth factor receptor, phosphorylated ERalpha [pERalpha]).