Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy.
Zürich, Switzerland. In Annu Rev Pharmacol Toxicol, Feb 2016
Research spanning (genetically engineered) animal models, healthy volunteers, and sleep-disordered patients has identified the neurotransmitters and neuromodulators dopamine, serotonin, norepinephrine, histamine, hypocretin, melatonin, glutamate, acetylcholine, γ-amino-butyric acid, and adenosine as important players in the regulation and maintenance of sleep-wake-dependent changes in neuronal activity and the sleep-wake continuum.
The Neurobiology of Sleep and Wakefulness.
Menlo Park, United States. In Psychiatr Clin North Am, Dec 2015
These wake-promoting systems are regulated by hypothalamic hypocretin/orexins, while GABAergic sleep-promoting nuclei are found in the preoptic area, brainstem and lateral hypothalamus.
EEG effect of orexin A in freely moving rats.
Budapest, Hungary. In Acta Physiol Hung, 2012
Orexin A administration differently affected fronto-occipital EEG waves in the different frequency bands recorded for 24 hours. Delta (1-4 Hz) and alpha (10-16 Hz) power decreased, while theta (4-10 Hz) and beta (16-48 Hz) power increased.