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Hyaluronoglucosaminidase 1

hyaluronidase, Hyaluronoglucosaminidase
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, CD44
Papers using hyaluronidase antibodies
InnateDB: facilitating systems-level analyses of the mammalian immune response
Supplier
Mookherjee Neeloffer et al., In Arthritis Research & Therapy, 2007
... In brief, the tissues were digested with 1 mg/ml collagenase and 0.05 mg/ml hyaluronidase (Sigma Aldrich) in Hanks' balanced salt ...
Papers on hyaluronidase
Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators.
New
Gonçalves et al., Campinas, Brazil. In Am J Reprod Immunol, Feb 2016
We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human β-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation.
Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots.
New
Gu et al., Raleigh, United States. In Nano Lett, Feb 2016
Herein, we describe a "transformable" core-shell based nanocarrier (designated CS-NG), which can enzymatically assemble into microsized extracellular depots at the tumor site with assistance of hyaluronidase (HAase), an overexpressed enzyme at the tumor microenvironment.
Highly efficient production of hyaluronic acid by S. zooepidemicus R42 derived from heterologous expression of bacterial hemoglobin and mutant selection.
New
Li et al., Lanzhou, China. In Lett Appl Microbiol, Feb 2016
Finally, we generated a hyaluronidase-negative and rifampin-resistant mutant strain that produces high levels of HA.
Cryopreservation of a small number of human sperm using enzymatically fabricated, hollow hyaluronan microcapsules handled by conventional ICSI procedures.
New
Hosoi et al., Ōsaka, Japan. In J Assist Reprod Genet, Feb 2016
After thawing, the capsule was degraded by hyaluronidase, and the recovery rate of sperm and their motility were investigated.
A ratiometric fluorescent probe for hyaluronidase detection via hyaluronan-induced formation of red-light emitting excimers.
New
Wu et al., Guangzhou, China. In Biosens Bioelectron, Feb 2016
UNASSIGNED: Hyaluronidase (HAase), which is involved in various physiological and pathological processes, can selectively degrade hyaluronan (HA) into small fragments, and it has been reported as a diagnostic and prognostic biomarker for bladder cancer.
Hyaluronidase Caveats in Treating Filler Complications.
Review
New
Landau, H̱olon, Israel. In Dermatol Surg, Dec 2015
BACKGROUND: Most of the complications associated with hyaluronic acid (HA) fillers can be addressed by hyaluronidase.
Property and current clinical applications of mammal hyaluronidase.
Review
New
Li et al., Shanghai, China. In Eur Rev Med Pharmacol Sci, Oct 2015
Hyaluronidase (Hyal), which is related to mammalian diseases, is greatly significant for mammal.
Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases.
Review
Back et al., Beaverton, United States. In Int J Cell Biol, 2014
A number of studies, for example, suggest that both the removal of high molecular weight HA and the accumulation of hyaluronidase-generated HA digestion products can impact CNS injuries through mechanisms that include the regulation of progenitor cell differentiation and proliferation.
Can Plasma Hyaluronan and Hyaluronidase Be Used As Markers of the Endothelial Glycocalyx State in Patients with Kidney Disease?
Review
Krediet et al., In Adv Perit Dial, 2014
In patients with kidney disease, plasma HA is higher than expected, but the extent to which plasma HA and its degrading enzyme hyaluronidase can be used as markers for the state of the EG has not yet been determined.
The management of biofilm formation after hyaluronic acid gel filler injections: a review.
Review
Georgescu et al., Cluj-Napoca / Kolozsvár, Romania. In Clujul Med, 2012
Removal of HA with hyaluronidase has also been proposed.
Hyaluronidase 1 and β-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation.
GeneRIF
Triggs-Raine et al., Winnipeg, Canada. In J Biol Chem, 2012
both HYAL1 and beta-hexosaminidase cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase. These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown.
Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process.
GeneRIF
Carmona et al., Montréal, Canada. In J Cell Physiol, 2012
Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway.
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
GeneRIF
Chung et al., New York City, United States. In J Inherit Metab Dis, 2011
In contrast to the previously described MPS IX patient, our three patients display a phenotype limited to the joints, suggesting that this is the primary manifestation of HYAL1 deficiency.
Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer.
GeneRIF
Carmona et al., Montréal, Canada. In Plos One, 2010
This is the first report showing high HYAL-1 levels in epithelial ovarian cancer.
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
GeneRIF
Ren et al., Chongqing, China. In Plos One, 2010
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
Sheep retrovirus structural protein induces lung tumours.
Impact
Miller et al., Seattle, United States. In Nature, 2005
The host range of JSRV is in part limited by species-specific differences in the virus entry receptor, hyaluronidase 2 (Hyal2), which is not functional as a receptor in mice but is functional in humans.
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.
Impact
Jain et al., Boston, United States. In Nat Med, 2004
The ratio of these two components depends on molecular size and can be altered in vivo with hyaluronidase and collagenase.
Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria.
Impact
Brown et al., Australia. In Nat Med, 2000
In laboratory isolates selected for specific high-level adhesion, binding to hyaluronic acid could be inhibited by dodecamer or larger oligosaccharide fragments or polysaccharides, treatment of immobilized receptor with hyaluronidase, or treatment of infected erythrocytes with trypsin.
Glycocalyx is not required for show inward calcium current in isolated rat heart myocytes.
Impact
Klöckner et al., In Nature, 1980
The glycocalyx is destroyed in myocytes dissociated from adult heart tissue with solutions containing low calcium, collagenase and hyaluronidase (Fig. 1).
VENOM AND VENOM APPARATUS OF THE BULL ANT, MYRMECIA GULOSA (FABR.).
Impact
WHITFIELD et al., In Science, 1964
The venom contains histamine, a hyaluronidase, and a direct hemolytic factor.
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