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Hyaluronoglucosaminidase 3

HYAL3, hyaluronidase 3
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: hyaluronidase, HYAL2, ACID, HAS3, HAD
Papers on HYAL3
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours.
New
Lindblad-Toh et al., Uppsala, Sweden. In Plos Genet, Nov 2015
In addition, disease associated haplotypes harbouring the hyaluronidase genes HYAL1, HYAL2 and HYAL3 on cfa20 and HYAL4, SPAM1 and HYALP1 on cfa14 were identified as separate risk factors in European and US golden retrievers, respectively, suggesting that turnover of hyaluronan plays an important role in the development of CMCT.
Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis.
New
Capelozzi et al., São Paulo, Brazil. In Braz J Med Biol Res, Nov 2015
Lower expression of Hyal-3 was found in atypical adenomatous hyperplasia than in basal cell hyperplasia (P=0.01) or moderate dysplasia (P=0.02).
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.
Review
New
Natowicz et al., Winnipeg, Canada. In World J Biol Chem, Sep 2015
Its levels are determined, in part, by the hyaluronan synthases, HAS1, HAS2, and HAS3, and three hyaluronidases, HYAL1, HYAL2 and HYAL3.
Homeostasis of hyaluronic acid in normal and scarred vocal folds.
New
Bless et al., Kyoto, Japan. In J Voice, Mar 2015
At 2 months, Has3 and Hyal3 mRNA showed higher expressions than normal.
Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients.
Ji et al., Bengbu, China. In Tumori, 2013
PURPOSE: In a previous study, we found a hyaluronidase 3 (HYAL3) gene mutation in exon 2 at position 188 by genome sequencing in a lung squamous cell carcinoma patient.
The inhibition of hyaluronan degradation reduced pro-inflammatory cytokines in mouse synovial fibroblasts subjected to collagen-induced arthritis.
Campo et al., Messina, Italy. In J Cell Biochem, 2012
Treatment of RASF with antioxidants and specific HYAL1, HYAL2, and HYAL3 small interference RNA (siRNAs) significantly reduced TLR-4 and CD44 increase in the mRNA expression and the related protein synthesis, as well as the release of inflammatory mediators up-regulated by TNF-α.
Molecular characterization of kidney cancer: association of hyaluronic acid family with histological subtypes and metastasis.
Lokeshwar et al., Miami, United States. In Cancer, 2012
The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM).
Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process.
GeneRIF
Carmona et al., Montréal, Canada. In J Cell Physiol, 2012
Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway.
Hyaluronidase splice variants are associated with histology and outcome in adenocarcinoma and squamous cell carcinoma of the lung.
Capelozzi et al., São Paulo, Brazil. In Hum Pathol, 2012
HYAL1-wild-type (wt) and variants 1 to 5, HYAL2-wt, and HYAL3-wt, and variants 1 to 3 were identified by polymerase chain reaction and direct sequencing.
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
Mukhopadhyay et al., New Delhi, India. In Dis Markers, 2011
We examined potential association of the single nucleotide polymorphisms (SNPs) of the HA synthesizing gene - hyaluronan synthase 2 (HAS2), hyaluronan binding protein 1 (HABP1) and HA catabolic gene hyaluronidase 3 (HYAL3) in the primary open angle glaucoma (POAG) patients in the Indian population.
Hyaluronan synthase and hyaluronidase expression in serous ovarian carcinoma is related to anatomic site and chemotherapy exposure.
Davidson et al., Jerusalem, Israel. In Int J Mol Sci, 2011
HYAL3 mRNA was expressed as wild-type and variant 1-3 form, the latter more highly in primary carcinomas and effusions compared to solid metastases (p = 0.006).
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines.
Rainho et al., São Paulo, Brazil. In Epigenetics, 2011
tumor suppressor gene cluster flanking RASSF1 (i.e., SEMA3B, HYAL3, HYAL2, HYAL1, TUSC2, RASSF1, ZMYND10, NPRL2, TMEM115, and CACNA2D2).
Changes in epidermal hyaluronan metabolism following UVB irradiation.
Inoue et al., Odawara, Japan. In J Dermatol Sci, 2011
On day 3, the average HA molecular mass drastically decreased to 100 kDa, while Hyal1, Hyal2, and Hyal3 mRNA expressions slightly increased.
Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes.
Maquart et al., Reims, France. In Photochem Photobiol, 2011
The mRNA expression of HYAL1, HYAL2 and HYAL3 and the hyaluronidase enzymatic activity were quantified using real-time PCR and a microtiter-based assay, respectively.
Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis.
GeneRIF
Papakonstantinou et al., Thessaloníki, Greece. In J Eur Acad Dermatol Venereol, 2011
Nodular basal cell carcinoma is associated with increased levels of hyaluronic acid concomitant with upregulation of gene expression of HAS3, HYAL3 and RHAMM, when compared with normal adjacent skin.
Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm.
GeneRIF
Martin-Deleon et al., Newark, United States. In Mol Reprod Dev, 2010
Hyal3 null sperm showed delayed cumulus penetration and reduced acrosomal exocytosis.
Involvement of hyaluronidases in colorectal cancer.
GeneRIF
Vynios et al., Pátrai, Greece. In Bmc Cancer, 2009
Overexpression of HYAL3 is associated with colorectal cancer.
Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.
GeneRIF
Triggs-Raine et al., Winnipeg, Canada. In Matrix Biol, 2008
HYAL3 does not play a major role in constitutive hyaluronan degradation
The six hyaluronidase-like genes in the human and mouse genomes.
Review
Stern et al., San Francisco, United States. In Matrix Biol, 2001
Three genes (HYAL1, HYAL2 and HYAL3) are clustered on chromosome 3p21.3,
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