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Hyaluronoglucosaminidase 2

HYAL2, hyaluronidase 2, lysosomal hyaluronidase
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: hyaluronidase, ACID, CD44, CAN, HYAL3
Papers using HYAL2 antibodies
The expanding role of mitochondria in apoptosis.
Chang Nan-Shan, In BMC Cell Biology, 2000
... The presence of GFP-Hyal-1 and GFP-Hyal-2 proteins in these stable transfectants was examined by Western blotting using anti-GFP antibodies (Clontech).
Papers on HYAL2
Whole exome sequencing of relapsed/refractory patients expands the repertoire of somatic mutations in diffuse large B-cell lymphoma.
Jardin et al., Rouen, France. In Genes Chromosomes Cancer, Mar 2016
Sequencing-based copy number analysis defined 23 short recurrently altered regions involving genes such as REL, CDKN2A, HYAL2, and TP53.
The human endogenous retrovirus K(HML-2) has a broad envelope-mediated cellular tropism and is prone to inhibition at a post-entry, pre-integration step.
Bannert et al., Berlin, Germany. In Virology, Jan 2016
In an initial effort to identify a receptor for HERV-K(HML-2) we investigated whether transferrin receptor 1 and hyaluronidase 2, known cellular receptors of the closely related betaretroviruses mouse mammary tumor virus (MMTV) and Jaagsiekte sheep retrovirus (JSRV), could facilitate HERV-K(HML-2) entry.
Hyaluronidase 2 (HYAL2) is expressed in endothelial cells, as well as some specialized epithelial cells, and is required for normal hyaluronan catabolism.
Triggs-Raine et al., Winnipeg, Canada. In Histochem Cell Biol, Jan 2016
Hyaluronidase 2 (HYAL2) is a membrane-anchored protein that is proposed to initiate the degradation of hyaluronan (HA) in the extracellular matrix.
Hyaluronic acid alkyl derivative: A novel inhibitor of metalloproteases and hyaluronidases.
Guarise et al., Abano Terme, Italy. In Int J Biol Macromol, Jan 2016
The in vitro results were confirmed by the inhibition of human MMP13 (Ki=106.1μM) and hyaluronidase-2 in the synovial fluid of patients with osteoarthritis.
Accelerating matchmaking of novel dysmorphology syndromes through clinical and genomic characterization of a large cohort.
Alkuraya et al., Riyadh, Saudi Arabia. In Genet Med, Jan 2016
RESULTS: Consistent with the apparent novelty of the phenotypes, our analysis revealed a strong candidate variant in genes that were novel at the time of the analysis in the majority of cases, and 10 of these genes are published here for the first time as novel candidates (CDK9, NEK9, ZNF668, TTC28, MBL2, CADPS, CACNA1H, HYAL2, CTU2, and C3ORF17).
Methylation status at HYAL2 predicts overall and progression-free survival of colon cancer patients under 5-FU chemotherapy.
Burwinkel et al., Germany. In Genomics, Dec 2015
Here, we describe that DNA methylation levels at CpG loci of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil (5-FU) chemotherapy with respect to overall survival and progression-free survival.
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours.
Lindblad-Toh et al., Uppsala, Sweden. In Plos Genet, Nov 2015
In addition, disease associated haplotypes harbouring the hyaluronidase genes HYAL1, HYAL2 and HYAL3 on cfa20 and HYAL4, SPAM1 and HYALP1 on cfa14 were identified as separate risk factors in European and US golden retrievers, respectively, suggesting that turnover of hyaluronan plays an important role in the development of CMCT.
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.
Natowicz et al., Winnipeg, Canada. In World J Biol Chem, Sep 2015
Its levels are determined, in part, by the hyaluronan synthases, HAS1, HAS2, and HAS3, and three hyaluronidases, HYAL1, HYAL2 and HYAL3.
Langerhans Cell-Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1.
Geijtenbeek et al., Amsterdam, Netherlands. In J Immunol, Sep 2015
Induction of the enzyme hyaluronidase-2 by DC maturation allowed degradation of hyaluronic acid and abrogated LC-DC interactions.
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat.
Seluanov et al., Rochester, United States. In Nature, 2013
However, once high-molecular-mass HA is removed by either knocking down HAS2 or overexpressing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant transformation and readily form tumours in mice.
Fragmented hyaluronan is an autocrine chemokinetic motility factor supported by the HAS2-HYAL2/CD44 system on the plasma membrane.
Harigaya et al., Chiba, Japan. In Int J Oncol, 2011
HAS2-HYAL2/CD44 system may support spontaneous chemokinesis of human cancer cells through self-degradation of HMW-HA to produce LMW-HA by an autocrine mechanism.
Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation.
Forteza et al., Miami, United States. In J Biol Chem, 2010
ROS induce Hyal2, suggesting that Hyal2 is likely responsible for the sustained HA fragmentation in the airway lumen observed in inflammatory conditions associated with oxidative stress.
Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins.
Neeman et al., Israel. In Neoplasia, 2010
Data show that a significant in expression levels of HA synthases (HASs) and hyaluronidases (Hyals) was observed in vitro on stimulation of epithelial ovarian carcinoma cells by gonadotropins.
Involvement of hyaluronidases in colorectal cancer.
Vynios et al., Pátrai, Greece. In Bmc Cancer, 2009
Overexpression of HYAL2 is associated with colorectal cancer.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.
Anttila et al., Kuopio, Finland. In Bmc Cancer, 2009
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
Evaluation of the 3p21.3 tumour-suppressor gene cluster.
Latif et al., Dundee, United Kingdom. In Oncogene, 2007
The candidate genes are HYAL2, FUS1, Ras-associated factor 1 (RASSF1), BLU/ZMYND10, NPR2L, 101F6, PL6 and CACNA2D2.
Why do we not all die of cancer at an early age?
Zabarovsky et al., Stockholm, Sweden. In Adv Cancer Res, 2006
These genes, LTF, L1MD1, HYAL1, HYAL2, and VHL, are of particular interest because they may be involved in microenvironmental control.
Ovine endogenous betaretroviruses (enJSRVs) and placental morphogenesis.
Spencer et al., College Station, United States. In Placenta, 2006
Hyaluronidase 2 (HYAL2), which can serve as a cellular receptor for JSRV and enJSRVs envelope (Env), is expressed by the trophoblast giant binucleate cells and multinucleated syncytia of the placenta.
Sheep retrovirus structural protein induces lung tumours.
Miller et al., Seattle, United States. In Nature, 2005
The host range of JSRV is in part limited by species-specific differences in the virus entry receptor, hyaluronidase 2 (Hyal2), which is not functional as a receptor in mice but is functional in humans.
Devising a pathway for hyaluronan catabolism: are we there yet?
Stern, San Francisco, United States. In Glycobiology, 2003
It is proposed that the high molecular weight extracellular polymer is tethered to the cell surface by the combined efforts of hyaluronan receptors and hyaluronidase-2 (Hyal-2).
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