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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 22 Nov 2014.

Huntingtin

huntingtin
Top mentioned proteins: CAN, AGE, ACID, V1a, Brain-derived neurotrophic factor
Papers using huntingtin antibodies
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Supplier
Flotte Terence R et al., In Molecular Therapy, 2002
... Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice ...
Modulation of the in situ activity of tissue transglutaminase by calcium and GTP
Supplier
Johnson Gail V.W. et al., In The Journal of Cell Biology, 1997
... The BamHI–XhoI huntingtin cDNA fragments were also subcloned into the Amersham Pharmacia Biotech and XhoI sites of the pECFP-N1 vector (CLONTECH Laboratories, Inc.) (N-Q18) (pECFP-N1-18Q) ...
Papers on huntingtin
Differential effects of delayed aging on phenotype and striatal pathology in a murine model of huntington disease.
New
Albin et al., Ann Arbor, United States. In J Neurosci, 19 Dec 2014
To assess whether delayed aging retards the effects of a mutant allele causing a Huntington's disease (HD)-like syndrome, we generated compound mutant mice, placing a dominant HD knock-in polyglutamine allele onto the slow-aging Snell dwarf genotype.
Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease.
New
Pouladi et al., Singapore, Singapore. In Mol Neurobiol, 15 Dec 2014
We show that mouse striatal neural cells expressing mutant huntingtin (HTT) exhibit increased MAO expression and activity.
Loss of the thyroid hormone binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
New
Brouillet et al., Fontenay-aux-Roses, France. In Hum Mol Genet, 14 Dec 2014
UNLABELLED: The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown.
Disruption of the Nuclear Membrane by Perinuclear Inclusions of Mutant Huntingtin Causes Cell-Cycle Re-entry and Striatal Cell Death in Mouse and Cell Models of Huntington's Disease.
New
Marsh et al., Taipei, Taiwan. In Hum Mol Genet, 14 Dec 2014
UNLABELLED: Accumulation of N-terminal fragments of mutant huntingtin (mHTT) in the cytoplasm, nuclei, and axons of neurons is a hallmark of Huntington's disease (HD), although how these fragments negatively impact neurons remains unclear.
Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases.
New
Impact
Su et al., Beijing, China. In Annu Rev Pharmacol Toxicol, 17 Nov 2014
Cleavage at the caspase-6 site in mutated huntingtin protein is a prerequisite for the development of the characteristic behavioral and neuropathological features of Huntington's disease.
Autophagy in Huntington disease and huntingtin in autophagy.
Review
New
Hayden et al., Vancouver, Canada. In Trends Neurosci, 01 Nov 2014
In Huntington disease (HD), an expansion of the polyglutamine (polyQ) tract in the N-terminus of the huntingtin (HTT) protein leads to protein aggregation.
Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases.
New
Impact
Lieberman et al., Ann Arbor, United States. In Annu Rev Pharmacol Toxicol, 25 Oct 2014
Critical target proteins that unfold and aggregate in these diseases, such as the polyglutamine androgen receptor in spinal and bulbar muscular atrophy, huntingtin in Huntington's disease, α-synuclein in Parkinson's disease, and tau in Alzheimer's disease, are client proteins of heat shock protein 90 (Hsp90), and their turnover is regulated by the protein quality control function of the Hsp90/Hsp70-based chaperone machinery.
Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.
Review
New
Impact
Bezard et al., New York City, United States. In Lancet, Sep 2014
In Huntington's disease, strategies might also be directed at mitochondrial bioenergetics and turnover, the prevention of protein dysregulation, disruption of the interaction between huntingtin and p53 or huntingtin-interacting protein 1 to reduce apoptosis, and interference with expression of mutant huntingtin at both the nucleic acid and protein levels.
Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease.
New
Impact
Snyder et al., Baltimore, United States. In Nature, Jun 2014
Huntington's disease is an autosomal dominant disease associated with a mutation in the gene encoding huntingtin (Htt) leading to expanded polyglutamine repeats of mutant Htt (mHtt) that elicit oxidative stress, neurotoxicity, and motor and behavioural changes.
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
New
Impact
Yang et al., Los Angeles, United States. In Nat Med, May 2014
Huntington's disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in huntingtin.
Differential Effect of HDAC3 on Cytoplasmic and Nuclear Huntingtin Aggregates.
New
Iwata et al., Tokyo, Japan. In Plos One, Dec 2013
HDAC3 directly binds to huntingtin (Htt) with short pQ and this interaction is important for suppressing neurotoxicity induced by HDAC3.
Ubiquitin-proteasome system involvement in Huntington's disease.
Review
New
Lucas et al., Madrid, Spain. In Front Mol Neurosci, Dec 2013
Huntington's disease (HD) is a genetic autosomal dominant neurodegenerative disease caused by the expansion of a CAG repeat in the huntingtin (htt) gene.
Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease.
Review
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Brouillet et al., Fontenay-aux-Roses, France. In Front Cell Neurosci, Dec 2013
HD is caused by a mutation in the huntingtin gene that consists in a CAG repeat expansion translated into an abnormal poly-glutamine (polyQ) tract in the huntingtin (Htt) protein.
Proteostasis in striatal cells and selective neurodegeneration in Huntington's disease.
Review
New
Finkbeiner et al., San Francisco, United States. In Front Cell Neurosci, Dec 2013
Although mutant huntingtin, the protein responsible for HD, is expressed ubiquitously, a subpopulation of neurons in the striatum is the first to succumb.
Skeletal muscle pathology in Huntington's disease.
Review
New
Mielcarek et al., Poznań, Poland. In Front Physiol, Dec 2013
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by the expansion of a polyglutamine stretch within the huntingtin protein (HTT).
Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.
GeneRIF
Humbert et al., Orsay, France. In Neuron, 2010
The specific disruption of Drosophila huntingtin in neuroblast precursors leads to spindle misorientation; Drosophila huntingtin restores spindle misorientation in mammalian cells.
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.
GeneRIF
Perrimon et al., Boston, United States. In Genetics, 2010
a genomewide RNA interference screen for regulators of mutant Htt aggregation
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.
GeneRIF
Perrimon et al., Boston, United States. In Dis Model Mech, 2009
dHtt is required for maintaining the mobility and long-term survival of adult animals, and for modulating axonal terminal complexity in the adult brain.
Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models.
GeneRIF
Okazawa et al., Tokyo, Japan. In Plos One, 2008
mutant ataxin-1 and huntingtin induce developmental and late-onset neuronal pathologies in Drosophila models
RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation.
GeneRIF
Nukina et al., Wako, Japan. In Plos One, 2008
genes related to nuclear transport, nucleotide processes, and signaling are modifiers of huntingtin aggregation
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