Molecular Genetics of Huntington's Disease.
Kérkyra, Greece. In Adv Exp Med Biol, 31 Dec 2014
Huntington's disease is a neurodegenerative disorder of the brain that is caused by the mutation of the gene which produces a protein called huntingtin (htt).
Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases.
Ann Arbor, United States. In Annu Rev Pharmacol Toxicol, 25 Oct 2014
Critical target proteins that unfold and aggregate in these diseases, such as the polyglutamine androgen receptor in spinal and bulbar muscular atrophy, huntingtin in Huntington's disease, α-synuclein in Parkinson's disease, and tau in Alzheimer's disease, are client proteins of heat shock protein 90 (Hsp90), and their turnover is regulated by the protein quality control function of the Hsp90/Hsp70-based chaperone machinery.