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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ELAV

HuD
Top mentioned proteins: CAN, GAP-43, GAP, HAD, V1a
Papers on HuD
Clusters of Structurally Similar MHC I HLA-A2 Molecules, Found with a New Method, Suggest Mechanisms of T-Cell Receptor Avidity.
New
Jernigan et al., Teaneck, United States. In Biochemistry, Feb 2016
Binding of CD8 to SC2-HLA-A2 (Tax-type Ag-s) changes it to SC1-HLA-A2 (HuD-type Ag-s).
Multinodular and vacuolating neuronal tumor affecting amygdala and hippocampus: A quasi-tumor?
New
Isozaki et al., Tokyo, Japan. In Pathol Int, Jan 2016
MVNT are composed of vacuolating dysplastic neurons reactive to HuC/HuD.
Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors.
New
Hyodo et al., Koshigaya, Japan. In Neuropathology, Dec 2015
They are characterized by multiple tumor nodules, vacuolar alteration and widespread immunolabeling for human neuronal protein HuC/HuD.
RNA-stabilizing proteins as molecular targets in cardiovascular pathologies.
Review
New
Krishnamurthy et al., Houston, United States. In Trends Cardiovasc Med, Nov 2015
Many mRNA binding proteins have been discovered to date, which either stabilize (HuR/HuA, HuB, HuC, HuD) or destabilize (AUF1, tristetraprolin, KSRP) the target transcripts.
Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis.
New
Zhao et al., Shanghai, China. In Proc Natl Acad Sci U S A, Oct 2015
The mammalian embryonic lethal abnormal vision (ELAV)-like protein HuD is a neuronal RNA-binding protein implicated in neuronal development, plasticity, and diseases.
Different motif requirements for the localization zipcode element of β-actin mRNA binding by HuD and ZBP1.
New
Yoo et al., Wilmington, United States. In Nucleic Acids Res, Oct 2015
ZBP1 and HuD are RBPs that play pivotal roles in mRNA transport and local translational control in neuronal processes.
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study.
New
Maddison et al., Oxford, United Kingdom. In Neurology, Aug 2015
HuD (41.7%), or P/Q VGCC (50%), irrespective of their syndrome.
Mammalian Target of Rapamycin (mTOR) Tagging Promotes Dendritic Branch Variability through the Capture of Ca2+/Calmodulin-dependent Protein Kinase II α (CaMKIIα) mRNAs by the RNA-binding Protein HuD.
New
Raab-Graham et al., Austin, United States. In J Biol Chem, Jul 2015
Overexpression of the RNA-stabilizing protein HuD increased CaMKIIα protein levels and preserved its selective expression in one daughter branch over the other when mTOR was inhibited.
Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.
New
Galeotti et al., Florence, Italy. In Exp Neurol, May 2015
To further clarify the pathway involved, we investigated the role of HuD, a RNA binding protein involved in neuronal function.
HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites.
Xu et al., Washington, D.C., United States. In Plos One, 2014
We demonstrate that the neuronal ELAV family of RNA binding proteins associates in vivo with several Bdnf mRNA isoforms present in the adult brain in an activity-dependent manner, and that one member, HuD, interacts directly with sequences in the long Bdnf 3' untranslated region (3'UTR) and co-localizes with Bdnf mRNA in dendrites of hippocampal neurons.
RNA-binding proteins in neurological diseases.
Review
Wu et al., In Sci China Life Sci, 2014
Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction.
Review
Jasmin et al., Ottawa, Canada. In Rna, 2013
In this context the best-characterized neuronal RBP, the Hu/ELAVl family member HuD, is emerging as a key component in multiple regulatory processes--including pre-mRNA processing, mRNA stability, and translation--governing the fate of a substantial amount of neuronal mRNAs.
Role of HuD in nervous system function and pathology.
Review
Bird et al., Albuquerque, United States. In Front Biosci (schol Ed), 2012
Hu proteins are a family of RNA-binding proteins (RBPs) that are homologs of Drosophila ELAV, a protein required for nervous system development.
Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation.
Review
Pfeilschifter et al., Frankfurt am Main, Germany. In Curr Protein Pept Sci, 2012
The ubiquitous mRNA-binding protein human antigen R (HuR) and its neuronal relatives (HuB, HuC, HuD) participate in the post-transcriptional regulation of many AU-rich element-bearing mRNAs.
RNA-binding protein HuD controls insulin translation.
GeneRIF
Gorospe et al., Baltimore, United States. In Mol Cell, 2012
HuD controls insulin II translation
Identification of ELAVL4 as a modulator of radiation sensitivity in A549 non-small cell lung cancer cells.
GeneRIF
Bae et al., Seoul, South Korea. In Oncol Rep, 2011
the endogenous function of ELAVL4 in relation to radiation sensitivity might be the regulation of cell proliferation and death
Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits.
GeneRIF
Sahin et al., Boston, United States. In Proc Natl Acad Sci U S A, 2011
Data show that SMN and HuD form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons.
Microtubule association of a neuronal RNA-binding protein HuD through its binding to the light chain of MAP1B.
GeneRIF
Sakamoto et al., Kōbe, Japan. In Biochimie, 2011
HuD simultaneously binds both RNA and MAP1B-light chain 1 (MAP1B-LC1) in vitro and that it tightly associates with microtubules in cells in an LC1-dependent manner
Increased expression of axogenesis-related genes and mossy fibre length in dentate granule cells from adult HuD overexpressor mice.
GeneRIF
Bolognani et al., Albuquerque, United States. In Asn Neuro, 2010
These results support the notion that HuD stabilizes a number of developmentally regulated mRNAs in dentate granule cells, resulting in increased axonal elongation.
HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal.
Impact
Furneaux et al., New York City, United States. In Cell, 1991
The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing.
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