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HtrA serine peptidase 1

htrA, HTRA1
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, Complement Factor H, CAN, ARMS2, HAD
Papers on htrA
Reticular Pseudodrusen and Their Association with Age-Related Macular Degeneration: The Melbourne Collaborative Cohort Study.
New
Guymer et al., Melbourne, Australia. In Ophthalmology, Jan 2016
The ARMS2 single nucleotide polymorphism (SNP) rs10490924, HTRA1 SNPs rs11200638 and rs3793917, and CFH SNPs rs393955, rs1061170, and rs2274700 were associated with increased prevalence of RPD (all P < 0.05).
Next-Generation Bacillus anthracis Live Attenuated Spore Vaccine Based on the htrA(-) (High Temperature Requirement A) Sterne Strain.
New
Shafferman et al., Israel. In Sci Rep, Dec 2015
Here we demonstrate that disrupting the htrA gene, encoding the chaperone/protease HtrA (High Temperature Requirement A), in the virulent Bacillus anthracis Vollum strain results in significant virulence attenuation in guinea pigs, rabbits and mice, underlying the universality of the attenuated phenotype associated with htrA knockout.
Association of Genetic Variants with Polypoidal Choroidal Vasculopathy: A Systematic Review and Updated Meta-analysis.
Review
New
Chen et al., Hong Kong, Hong Kong. In Ophthalmology, Sep 2015
Another 25 polymorphisms in 13 genes (ARMS2, HTRA1, C2, CFB, ELN, LIPC, LPL, ABCA1, VEGF-A, TLR3, LOXL1, SERPING1, and PEDF) had no significant association.
Adult-onset foveomacular vitelliform dystrophy: A fresh perspective.
Review
New
Boon et al., Jerusalem, Israel. In Prog Retin Eye Res, Jul 2015
A single-nucleotide polymorphism in the HTRA1 gene has also been associated with this phenotype.
Age-related macular degeneration: genome-wide association studies to translation.
Review
New
Clark et al., Manchester, United Kingdom. In Genet Med, Jun 2015
Two loci in particular, including genes of the complement cascade on chromosome 1 and the ARMS2/HTRA1 genes on chromosome 10, have been shown to convey significantly increased susceptibility to developing AMD.
Shifting the CARASIL paradigm: report of a non-Asian family and literature review.
Review
New
Basílio et al., Portugal. In Stroke, Apr 2015
BACKGROUND AND PURPOSE: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare form of nonhypertensive cerebral small-vessel disease caused by mutations in the HTRA1 gene.
The secreted L-arabinose isomerase displays anti-hyperglycemic effects in mice.
Maguin et al., Jouy-le-Moutier, France. In Microb Cell Fact, 2014
Moreover, we showed an improvement in the enzyme secretion using either (1) L. lactis strains deficient for their two major proteases, ClpP and HtrA, or (2) an enhancer of protein secretion in L. lactis fused to the recombinant L-AI with the SP Usp45 .
Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter.
Liu et al., Beijing, China. In Int J Mol Sci, 2014
HtrA serine peptidase 2 (HtrA2), also named Omi, is a pro-apoptotic protein that exhibits dramatic changes in expression levels in a variety of disorders, including ischemia/reperfusion injury, cancer, and neurodegeneration.
High temperature requirement A1, transforming growth factor beta1, phosphoSmad2 and Ki67 in eutopic and ectopic endometrium of women with endometriosis.
Marzioni et al., Marche-en-Famenne, Belgium. In Eur J Histochem, 2014
Increasing evidence supports the hypothesis that TGFb1 signalling may be mediated by high temperature requirement A1 (HtrA1) serine protease, acting on important regulatory mechanisms such as cell proliferation and mobility.
[Age-related macular degeneration].
Review
Budzinskaia, In Vestn Oftalmol, 2014
The impact of polymorphism in particular genes, including complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2/LOC387715), and serine peptidase (HTRA1), on AMD development is discussed.
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.
GeneRIF
Seddon et al., Boston, United States. In Ophthalmology, 2012
ARMS2/HTRA1 locus confers increased risk for both advanced age-related macular degeneration subtypes, but imparts greater risk for choroid neovascularization than for geographic atrophy.
Association of pattern dystrophy with an HTRA1 single-nucleotide polymorphism.
GeneRIF
Chowers et al., Jerusalem, Israel. In Arch Ophthalmol, 2012
Adult-onset foveomacular vitelliform dystrophy and butterfly-shaped pigment dystrophy phenotypes are associated with an HTRA1 risk SNP
Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates.
GeneRIF
Ehrmann et al., Essen, Germany. In J Biol Chem, 2012
human HTRA1 degrades aggregated and fibrillar tau, a protein that is critically involved in various neurological disorders
Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration.
GeneRIF
Richards et al., Zürich, Switzerland. In J Biol Chem, 2012
a scenario in which HTRA1 promotes IVD degeneration through the proteolytic cleavage of fibronectin and subsequent activation of resident disc cells.
Structural and functional analysis of HtrA1 and its subdomains.
GeneRIF
Kirchhofer et al., San Francisco, United States. In Structure, 2012
the structure of the unliganded HtrA1 active site suggests a two-state equilibrium and a "conformational selection" model, in which substrate binds to the active conformer.
HTRA proteases: regulated proteolysis in protein quality control.
Review
Impact
Ehrmann et al., Vienna, Austria. In Nat Rev Mol Cell Biol, 2011
The unique molecular architecture of the widely conserved high temperature requirement A (HTRA) proteases has evolved to mediate critical aspects of ATP-independent protein quality control.
Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.
Impact
GeneRIF
Onodera et al., Niigata, Japan. In N Engl J Med, 2009
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy is associated with mutations in the HTRA1 gene.
Age-related macular degeneration.
Impact
Chew et al., Bethesda, United States. In Lancet, 2008
Genetic investigations have shown that complement factor H, a regulator of the alternative complement pathway, and LOC387715/HtrA1 are the most consistent genetic risk factors for age-related macular degeneration.
Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.
Impact
Lotery et al., Southampton, United Kingdom. In Lancet, 2008
Genetic studies have made advancements in establishing the molecular cause of this disease, identifying mutations in the complement factor H (CFH) gene and a locus on chromosome 10 encompassing the HTRA1/LOC387715/ARMS2 genes.
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA.
Impact
Weber et al., Regensburg, Germany. In Nat Genet, 2008
Signals at 10q26 center over two nearby genes, ARMS2 (age-related maculopathy susceptibility 2, also known as LOC387715) and HTRA1 (high-temperature requirement factor A1), suggesting two equally probable candidates.
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