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Forkhead box N2

HTLF, FOXN2, human T-cell leukemia virus enhancer factor
This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CHES1, ACID, Foxn1, FOXN5, Foxn4
Papers on HTLF
Transcriptomic profiling of Forkhead box transcription factors in adult glioblastoma multiforme.
Madhusudan et al., Nottingham, United Kingdom. In Cancer Genomics Proteomics, May 2015
RESULTS: Low FOXA2 mRNA, low FOXN2 mRNA, low FOXN3 mRNA and high FOXG1 mRNA were associated with poor survival in the test and TCGA validation cohorts.
LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation.
Bikle et al., United States. In J Steroid Biochem Mol Biol, 2014
Additionally there is an increase in the expression levels of other oncogenes (mHOTAIR, Malat1 and SRA) and a decrease of other tumor suppressors (Foxn2-as, Gtl2-as, H19-as).
Genome-wide Association Study of Integrated Meat Quality-related Traits of the Duroc Pig Breed.
Seo et al., Seoul, South Korea. In Asian-australas J Anim Sci, 2014
The SNPs associated with meat quality are in or near five genes (ANK1, BMP6, SHH, PIP4K2A, and FOXN2) and have been reported previously.
Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia.
Yang et al., Shijiazhuang, China. In Clin Biochem, 2011
HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of gastric cardia adenocarcinoma.
Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy.
Kim et al., Seoul, South Korea. In J Mol Med (berl), 2007
We found that DNMT1-targeted inhibition induced the re-expression and reversed DNA methylation of five (CDKN2A, RASSF1A, HTLF, RUNX3, and AKAP12B) out of seven genes examined, and 5-aza-dC reactivated and demethylated all seven genes.
Characterization of human FOXN4 gene in silico.
Katoh et al., Japan. In Int J Mol Med, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1) and FOXN6 (FOXR2) genes constitute the FOXN gene family.
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4 and FOXN5 (FOXR1) constitute the FOXN family.
Identification and characterization of human FOXN5 and rat Foxn5 genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1) and FOXN4 constitute the FOXN family.
The murine fork head gene Foxn2 is expressed in craniofacial, limb, CNS and somitic tissues during embryogenesis.
Lufkin et al., New York City, United States. In Mech Dev, 2002
The dynamic and specific expression of Foxn2 during embryonic development suggest multiple independent roles for Foxn2 function during gestation
Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion.
Knuutila et al., Helsinki, Finland. In Leukemia, 2001
A cluster of genes, LCP1, PARP, BLR1, DEK, NPM, MCL1, SLP76, STAM, HIVEP1, EVI2B, CD25, HTLF, HIVEP2, BCL2, MNDA, PBX3, EB12, TCF1, CGRP, CD14, ILB, GZMK, GPR17 and CD79B, was associated (P < 0.05) with the unfavorable 11q deletion and also with the unfavorable Binet stages B and C. We present here gene expression profiling that is associated with CLL patients with the 11q23 deletion.
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis hypothesis. A shift of homologous peptides pairs, central nervous system (CNS)/HTLF-1, HTLV-1/thymus, thymus/CNS, in a thymus-like CNS environment, underlies the pathogenesis of HAM/TSP.
Plumelle, Fort-de-France, Martinique. In Med Hypotheses, 1999
Determinants shared by thymus, brain and HTLV-1 induce lymphocytic neurotropism and demyelinization in HAM/TSP, within the framework thymus-like brain environment.
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines.
Inazawa et al., Tokyo, Japan. In J Hum Genet, 1998
Chromosomes 14q32 and 2p16-22 harbor TCL1 and a transcription factor, HTLF (human T-cell leukemia virus enhancer factor), respectively.
Characterization of mouse and human nude genes.
Boehm et al., Heidelberg, Germany. In Immunogenetics, 1996
Nucleotide sequence database comparisons reveal that among other winged-helix genes, the HTLF and HTLFL1 genes are most closely related to whn, although the exon/intron structure of the human HTLF gene in the DNA binding domain differs from that of whn.
Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF.
Gaynor et al., Los Angeles, United States. In Genomics, 1992
This protein, which we designated human T-cell leukemia virus enhancer factor (HTLF), contains a domain with homology to the recently described fork head DNA binding domain.
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