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Taste receptor, type 2, member 31

hTAS2R44, TAS2R44
TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009] (from NCBI)
Top mentioned proteins: hTAS2R43, ACID, CAN, TAS2R50, hTAS2R46
Papers on hTAS2R44
Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners.
Wooding et al., Potsdam, Germany. In Hum Mol Genet, 2011
Haplotype analyses revealed that most associations were spurious, arising from LD with variants in TAS2R31.
Modulation of bitter taste perception by a small molecule hTAS2R antagonist.
Meyerhof et al., Cincinnati, United States. In Curr Biol, 2010
We employed a high-throughput screening approach to discover a novel bitter receptor antagonist (GIV3727) that inhibits activation of hTAS2R31 (formerly hTAS2R44) by saccharin and acesulfame K, two common artificial sweeteners.
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Meyerhof et al., Potsdam, Germany. In J Agric Food Chem, 2009
This paper presents the pharmacological characterization of this receptor and analyzes its functional relationship with the previously deorphaned hTAS2R43, hTAS2R44, hTAS2R46, and hTAS2R47.
Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.
Li et al., San Diego, United States. In Curr Biol, 2007
hT2R43 gene allele makes people more sensitive to the bitterness of an artificial sweetener, saccharin; in addition, a closely related gene's (hT2R44's) allele also makes people more sensitive to the bitterness of saccharin.
Bitter taste receptors for saccharin and acesulfame K.
Meyerhof et al., Potsdam, Germany. In J Neurosci, 2004
hTAS2R43 and hTAS2R44 function as cognate bitter taste receptors and do not contribute to the sweet taste of saccharin and acesulfame K.
Identification of ligands for two human bitter T2R receptors.
Keung et al., Los Angeles, United States. In Chem Senses, 2004
Activation by denatonium and 6-nitrosaccharin.
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