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Taste receptor, type 2, member 16

hTAS2R16, TAS2R16, T2R16
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TAS2R38, CAN, ACID, AGE, T2R4
Papers on hTAS2R16
Salicin from Willow Bark can Modulate Neurite Outgrowth in Human Neuroblastoma SH-SY5Y Cells.
New
Schempp et al., Freiburg, Germany. In Phytother Res, Oct 2015
Recently, it could be demonstrated that salicin binds and activates the bitter taste receptor TAS2R16.
Umami-bitter interactions: the suppression of bitterness by umami peptides via human bitter taste receptor.
New
Rhyu et al., South Korea. In Biochem Biophys Res Commun, Feb 2015
We investigated umami-bitter taste interactions by presenting umami peptides with bitter substance (salicin) on Ca(2+)-flux signaling assay using hTAS2R16-expressing cells.
Molecular cloning and evolutionary analysis of captive forest musk deer bitter taste receptor gene T2R16.
Jie et al., Chongqing, China. In Genet Mol Res, 2014
In the present study, we analyzed the structure and features of the protein encoded by the forest musk deer (Moschus berezovskii) T2R16 and submitted the gene sequence to NCBI GenBank.
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Tishkoff et al., Philadelphia, United States. In J Hum Genet, 2014
Prior studies have demonstrated that nonsynonymous variation at site 516 in the coding exon of TAS2R16, a bitter taste receptor gene on chromosome 7, has been subject to positive selection and is strongly correlated with differences in sensitivity to salicin, a bitter anti-inflammatory compound, in human populations.
Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa.
Tishkoff et al., United States. In Mol Biol Evol, 2014
To better understand the genetic architecture and patterns of phenotypic variability of bitter taste perception, we sequenced a 996 bp region, encompassing the coding exon of TAS2R16, a bitter taste receptor gene, in 595 individuals from 74 African populations and in 94 non-Africans from 11 populations.
Classic selective sweeps revealed by massive sequencing in cattle.
Simianer et al., Göttingen, Germany. In Plos Genet, 2014
We find 106 candidate selection regions, many of which are harboring genes related to phenotypes relevant in domestication, such as coat coloring pattern, neurobehavioral functioning and sensory perception including KIT, MITF, MC1R, NRG4, Erbb4, TMEM132D and TAS2R16, among others.
Do polymorphisms in chemosensory genes matter for human ingestive behavior?
Allen et al., United States. In Food Qual Prefer, 2013
For example, TAS2R16 polymorphisms are linked to the bitterness of naturally occurring plant compounds and alcoholic beverage intake, a TAS2R19 polymorphism predicts differences in quinine bitterness and grapefruit bitterness and liking, and TAS2R31 polymorphisms associate with differential bitterness of plant compounds like aristolochic acid and the sulfonyl amide sweeteners saccharin and acesulfame-K.
Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31.
Hayes et al., United States. In Chem Senses, 2013
Conversely, single nucleotide polymorphisms in TAS2R4, TAS2R38, and near TAS2R16 were not significant predictors.
Identification of novel genes for bitter taste receptors in sheep (Ovis aries).
Almeida et al., Évora, Portugal. In Animal, 2013
In sheep, we identified eight orthologs of cattle genes: T2R16, T2R10B, T2R12, T2R3, T2R4, T2R67, T2R13 and T2R5.
Assessment of the presence of chemosensing receptors based on bitter and fat taste in the gastrointestinal tract of young pig.
Bosi et al., Reggio nell'Emilia, Italy. In J Anim Sci, 2012
For 7 genes for bitter taste (TAS2R1, TAS2R3, TAS2R7, TAS2R9, TAS2R10, TAS2R16, and TAS2R38) and for 3 genes for fat taste (GPR40, GPR43, and GPR120), a full homology for exon sequences was found and primers were designed by Primer3.
Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk.
Marchand et al., Houston, United States. In Nutr Cancer, 2012
Using a case-control study of 914 colorectal adenoma cases/1188 controls, we explored associations among colorectal adenoma risk, dietary intake, and genetic variation in 3 bitter-taste receptor genes: TAS2R38 (rs713598, rs1726866, rs10246939), TAS2R16 (rs846672), and TAS2R50 (rs1376251).
Functional diversity of bitter taste receptor TAS2R16 in primates.
Hirai et al., Japan. In Biol Lett, 2012
Especially, the sensitivity of TAS2R16 of Japanese macaques to salicin was much lower than that of human TAS2R16, which was supported by behavioural tests.
Bitter taste receptor polymorphisms and human aging.
Barale et al., Heidelberg, Germany. In Plos One, 2011
We found that one polymorphism, rs978739, situated 212 bp upstream of the TAS2R16 gene, shows a statistically significant association (p = 0.001) with longevity.
Selection on the human bitter taste gene, TAS2R16, in Eurasian populations.
GeneRIF
Kidd et al., New Haven, United States. In Hum Biol, 2011
The authors discuss the association between the TAS2R16 gene and the evolution of bitter taste receptors in different populations.
The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.
GeneRIF
Abe et al., Japan. In Biochem Biophys Res Commun, 2010
TAS2R16 is responsible for the bitterness of gentiobiose.
Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.
GeneRIF
Abe et al., Japan. In J Biol Chem, 2010
molecular interaction between hTAS2R16 and beta-D-glucopyranoside
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
GeneRIF
Goate et al., Saint Louis, United States. In Alcohol Clin Exp Res, 2007
Functional variants in both TAS2R16 and TAS2R38 correlate with alcohol consumption in African-American families.
The genetics of alcoholism: identifying specific genes through family studies.
Review
Foroud et al., Indianapolis, United States. In Addict Biol, 2006
COGA has detected association to additional genes including GABRG3, TAS2R16, SNCA, OPRK1 and PDYN, results that are awaiting confirmation.
Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.
GeneRIF
Goate et al., Saint Louis, United States. In Am J Hum Genet, 2006
Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence, especially in African-Americans.
The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.
Impact
GeneRIF
Meyerhof et al., Potsdam, Germany. In Nat Genet, 2002
TAS2R16 is present in taste receptor cells on the tongue and is activated by bitter beta-glucopyranosides, and mediates bitter taste
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