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Sulfotransferase family, cytosolic, 2B, member 1

hsst2, SULT2B1
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: somatostatin, SULT2A1, ACID, HAD, Ndst1
Papers on hsst2
Quantitative Secretomic Analysis Identifies Extracellular Protein Factors that Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer.
New
Yu et al., In J Proteome Res, Feb 2016
RNA interference (RNAi)-mediated knock down of a number of these proteins, including SULT2B1, CEACAM5, SPRR3, AGR2, S100P and S100A14, leads to dramatically reduced migration of these cells.
Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.
New
Wright et al., Newcastle upon Tyne, United Kingdom. In Toxicol Lett, Jan 2016
B-13 and B-13/H cells expressed - relative to intact rat liver - high levels of SULT2B1 (primarily the b isoform) and SULT4A1 mRNAs and proteins.
Human sulfotransferases enhance the cytotoxicity of tolvaptan.
New
Beland et al., United States. In Toxicol Sci, Jan 2016
The affinity of individual SULT isozymes, as determined by Km analysis, was SULT1C3 ≫ SULT2A1 > SULT2B1 ~ SULT1B1 > SULT1E1.
The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism.
New
Rižner et al., Ljubljana, Slovenia. In Chem Biol Interact, Jul 2015
Considering the estrogen biosynthetic and metabolic enzymes, these cells showed statistically significant different gene expression profiles for SULT2B1, HSD3B2, CYP19A1, AKR1C3, HSD17B1, HSD17B7, HSD17B12, CYP1B1, CYP3A5, COMT, SULT1A1, GSTP1 and NQO2.
Identification of key genes affecting disease free survival time of pediatric acute lymphoblastic leukemia based on bioinformatic analysis.
Wang et al., Harbin, China. In Blood Cells Mol Dis, 2015
For the 75 key genes, 27 disease risk sub-pathways were identified, and HK3, HNMT, SULT2B1, KYNU, and PTGS2 were the significant key genes which were enriched in these sub-pathways.
Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
CPNDS consortium et al., Vancouver, Canada. In Pharmacogenomics, 2014
Additional evidence was found for SULT2B1 and several genes related to oxidative stress.
[111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors.
Reubi et al., Athens, Greece. In J Med Chem, 2014
Furthermore, [DOTA]LTT-SS28 behaved as an agonist at hsst2, hsst3, and hsst5, efficiently stimulating internalization of the three receptor subtypes.
Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.
Guillemette et al., Québec, Canada. In Clin Cancer Res, 2014
Specifically, we examined 71 single-nucleotide polymorphisms (SNP) in SULT2A1, SULT2B1, CYP1B1, COMT, CYP3A4, CYP3A5, CYP3A43, NQO1, and NQO2 and assessed the impact of the SNPs alone and in combination on prostate cancer progression and on circulating hormone levels.
Sex differences in apolipoprotein A1 and nevirapine-induced toxicity.
Pereira et al., Lisbon, Portugal. In J Int Aids Soc, 2013
Interestingly, apolipoprotein A1 (ApoA1) increases SULT2B1 activity and ApoA1 synthesis is increased by NVP [5, 6].
SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family.
Review
Rohn-Glowacki et al., Birmingham, United States. In Drug Metab Rev, 2013
The SULT2b gene family consists of a single gene capable of generating two functional transcripts utilizing different transcriptional start sites in the first exon.
SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer.
Chatterjee et al., San Antonio, United States. In Mol Endocrinol, 2013
Ligand-activated vitamin D receptor induced the SULT2B1 promoter in vivo in mouse prostate and increased SULT2B mRNA and protein levels in vitro in prostate cancer cells.
Genetic variants in sex hormone metabolic pathway genes and risk of esophageal squamous cell carcinoma.
Taylor et al., Madagascar. In Carcinogenesis, 2013
However, six individual genes (including SULT2B1, CYP1B1, CYP3A7, CYP3A5, SHBG and CYP11A1) were significantly associated with ESCC risk (P < 0.05).
Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo.
Li et al., Shanghai, China. In Plos One, 2012
Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) is highly selective for the addition of sulfate groups to 3β-hydroxysteroids.
Cytosolic sulfotransferase 2B1b promotes hepatocyte proliferation gene expression in vivo and in vitro.
GeneRIF
Ren et al., Shanghai, China. In Am J Physiol Gastrointest Liver Physiol, 2012
SULT2B1b may promote hepatocyte proliferation by inactivating oxysterol/LXR signaling.
Effects of synbiotic fermentation products on primary chemoprevention in human colon cells.
GeneRIF
Glei et al., Jena, Germany. In J Nutr Biochem, 2012
In HT29 cells expression of SULT2B1 was enhanced by probiotic fermentation supernatants without aleurone.
Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease.
GeneRIF
Ren et al., Richmond, United States. In Metabolism, 2012
increases in SULT2B1b expression were accompanied by reduction in key regulators and enzymes involved in lipid metabolism, including liver X receptor alpha, SREBP-1, SREBP-2, acetyl-CoA carboxylase-1, and fatty acid synthase.
Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.
GeneRIF
Ren et al., Richmond, United States. In Atherosclerosis, 2011
Sulfation of 25-hydroxycholesterol by SULT2B1b plays an important role in the maintenance of intracellular lipid homeostasis via the LXR/SREBP-1c signaling pathway in endothelial cells.
Mouse cytosolic sulfotransferase SULT2B1b interacts with cytoskeletal proteins via a proline/serine-rich C-terminus.
GeneRIF
Suiko et al., Miyazaki, Japan. In Febs J, 2010
results suggested that the unique, extended proline/serine-rich C-terminus of SULT2B1b is important for its interaction with cytoskeletal proteins
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Impact
Tontonoz et al., Los Angeles, United States. In Cell, 2008
T cell activation triggers induction of the oxysterol-metabolizing enzyme SULT2B1, consequent suppression of the LXR pathway for cholesterol transport, and promotion of the SREBP pathway for cholesterol synthesis.
Improved analogs and novel delivery systems for somatostatin octapeptides.
Review
Davis et al., Milford, United States. In Metabolism, 1996
Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2).
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