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TRNA splicing endonuclease 15 homolog

HsSen15, Sen15, Sen15p, C1orf19
tRNA splicing is a fundamental process required for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004 [PubMed 15109492]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Sen54, sen2, Sen34, STEP, HMGCS1
Papers on HsSen15
Derivation of a novel undifferentiated human foetal phenotype in serum-free cultures with BMP-2.
Oreffo et al., Southampton, United Kingdom. In J Cell Mol Med, 2009
In contrast, the addition of bone morphogenetic protein-2 (BMP-2) resulted in reduced ALP levels, increased amino acid metabolism and, strikingly, a marked shift to a cobblestone-like cellular morphology, with expression of SOX-2 and SOX-9 but not STRO-1 as shown by immunocytochemistry, and significantly altered expression of metabolic genes (GFPT2, SC4MOL and SQLE), genes involved in morphogenesis (SOX15 and WIF1) and differentiation potential (C1orf19, CHSY-2,DUSP6, HMGCS1 and PPL).
Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold.
Markley et al., Madison, United States. In J Mol Biol, 2007
Splicing of eukaryal intron-containing tRNAs requires the action of the heterotetrameric splicing endonuclease, which is composed of two catalytic subunits, Sen34 and Sen2, and two structural subunits, Sen15 and Sen54.
Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site.
Peltz et al., South Plainfield, United States. In Nature, 2006
The first step of splicing, intron recognition and cleavage, is performed by the tRNA-splicing endonuclease, a tetrameric enzyme composed of the protein subunits Sen54, Sen2, Sen34 and Sen15.
Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.
Trotta et al., South Plainfield, United States. In Cell, 2004
This enzyme consists of HsSen2, HsSen34, HsSen15, and HsSen54, homologs of the yeast tRNA endonuclease subunits.
Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria.
Endo et al., Nagoya, Japan. In Mol Biol Cell, 2003
In yeast, the tRNA splicing endonuclease that cleaves the exon-intron junctions of pre-tRNAs consists of Sen54p, Sen2p, Sen34p, and Sen15p and was thought to be an integral membrane protein of the inner nuclear envelope.
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