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BRICK1, SCAR/WAVE actin-nucleating complex subunit

HSPC300, BRK1, C3orf10
Component of the WAVE protein complex which act as activators of ARP2/3 complex involved in actin nucleation. Required for trichome morphogenesis. Required for accumulation of SCAR1 protein in vivo. Selectively stabilizes SCAR2. (from NCBI)
Top mentioned proteins: Actin, Arp2, WAVE, Wasp, VHL
Papers on HSPC300
MD and Docking Studies Reveal That the Functional Switch of CYFIP1 is Mediated by a Butterfly-like Motion.
New
Bagni et al., Leuven, Belgium. In J Chem Theory Comput, Aug 2015
Cytoplasmic FMRP interacting protein 1 (CYFIP1), also known as specifically RAC1 activated protein 1 (Sra1), plays a dual role: together with fragile X mental retardation protein (FMRP) and eIF4E it forms a complex that inhibits mRNA translation, while together with WAVE1, NCKAP1, ABI2, and HSPC300 it forms the WAVE regulatory complex (WRC) that upon RAC1 activation initiates actin polymerization.
Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis.
Favery et al., Antibes, France. In New Phytol, 2015
We show that Arabidopsis SAC proteins BUB3.1, MAD2, BUBR1/MAD3s and BRK1 interact with each other and with MAP65-3.
Sp1 transcriptionally regulates BRK1 expression in non-small cell lung cancer cells.
Zhang et al., Beijing, China. In Gene, 2014
Following a previous study reporting that BRK1 is upregulated in non-small cell lung cancer (NSCLC), the present study sought to clarify the role of specificity protein 1 (Sp1) in the transcriptional regulation of the BRK1 gene.
Molecular evidence for convergent evolution and allopolyploid speciation within the Physcomitrium-Physcomitrella species complex.
Rensing et al., Freiburg, Germany. In Bmc Evol Biol, 2013
RESULTS: Molecular analysis of the nuclear single copy gene BRK1 reveals that three Physcomitrium species feature larger genome sizes than Physcomitrella patens and encode two expressed BRK1 homeologs (polyploidization-derived paralogs), indicating that they may be allopolyploid hybrids.
Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.
Huang et al., Tainan City, Taiwan. In Gene, 2013
Three hypothetical genes, C3orf10, FAM134C, and ENOX1, were investigated because their NRF-1 response elements are 100% conserved in humans and mice.
BRK1, a Bub1-related kinase, is essential for generating proper tension between homologous kinetochores at metaphase I of rice meiosis.
Cheng et al., Beijing, China. In Plant Cell, 2012
Here, we identify a plant Bub1-related kinase 1 (BRK1) in rice (Oryza sativa).
Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions.
Zhu et al., Shanghai, China. In Cell Res, 2012
The WAVE regulatory complex (WRC), consisting of WAVE, Sra, Nap, Abi, and HSPC300, activates the Arp2/3 complex to control branched actin polymerization in response to Rac activation.
FusionFinder: a software tool to identify expressed gene fusion candidates from RNA-Seq data.
Beesley et al., Perth, Australia. In Plos One, 2011
These included two isoforms of a fusion involving the genes BRK1 and VHL, whose co-deletion has previously been associated with the prevalence and severity of renal-cell carcinoma.
SCAR mediates light-induced root elongation in Arabidopsis through photoreceptors and proteasomes.
Blancaflor et al., Ardmore, United States. In Plant Cell, 2011
The involvement of the ARP2/3-SCAR complex in light-regulated root growth is supported by our finding that mutants of the SCAR complex subunit BRK1/HSPC300, or other individual subunits of the ARP2/3-SCAR complex, showed a dramatic inhibition of root elongation in the light, which mirrored reduced growth of wild-type roots in the dark.
WAVE forms hetero- and homo-oligomeric complexes at integrin junctions in Drosophila visualized by bimolecular fluorescence complementation.
Bogdan et al., Münster, Germany. In J Biol Chem, 2011
WAVE (Wiskott-Aldrich syndrome protein family verprolin-homologous protein) proteins are found in a conserved pentameric heterocomplex that contains Abi, Kette/Nap1, Sra-1/CYFIP, and HSPC300.
High-resolution X-ray structure of the trimeric Scar/WAVE-complex precursor Brk1.
Faix et al., Hannover, Germany. In Plos One, 2010
The heteropentameric Scar/WAVE-complex is composed of Scar/WAVE, Abi, Nap, Pir and a small polypeptide Brk1/HSPC300, and recent work suggested that free Brk1 serves as a homooligomeric precursor in the assembly of this complex.
Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation.
GeneRIF
Malumbres et al., Madrid, Spain. In Cancer Res, 2010
Data show that Brk1 downregulation results in defective directional migration and invasive growth in renal cell carcinoma cells as well as in other tumor cell types.
Genotype-phenotype correlations in VHL exon deletions.
GeneRIF
Maher et al., Birmingham, United Kingdom. In Am J Med Genet A, 2009
Growing body of evidence suggesting that patients with VHL syndrome caused by large VHL deletions that include C3orf10 may be designated as having a specific subtype (Type 1B) of the disorder.
Metastatic potential of lung squamous cell carcinoma associated with HSPC300 through its interaction with WAVE2.
GeneRIF
Zhang et al., Beijing, China. In Lung Cancer, 2009
higher expression in primary lung tumours with lymph node metastases and also in tumours from patients with more advanced disease
Lilliputians get into the limelight: novel class of small peptide genes in morphogenesis.
Review
Kageyama et al., Okazaki, Japan. In Dev Growth Differ, 2008
Brick1/HSPC300 is an evolutionarily conserved component of the actin reorganization complex.
Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients.
GeneRIF
Robledo et al., Madrid, Spain. In Hum Mutat, 2007
Von Hippel-Lindau (VHL) locus deletion of the HSPC300 actin regulator gene greatly lowers risk of clear cell renal cell carcinoma development in Spanish VHL syndrome patients studied.
Arabidopsis BRICK1/HSPC300 is an essential WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2.
GeneRIF
Szymanski et al., West Lafayette, United States. In Curr Biol, 2006
member of the "distorted group" of trichome morphology mutants and a critical WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2
Regulation of actin assembly by SCAR/WAVE proteins.
Review
Insall et al., Birmingham, United Kingdom. In Biochem Soc Trans, 2005
SCAR/WAVEs are thought to be regulated by a pentameric complex which also contains Abi (Abl-interactor), Nap (Nck-associated protein), PIR121 (p53-inducible mRNA 121) and HSPC300 (haematopoietic stem progenitor cell 300), but the structural organization of the complex and the contribution of its individual components to the regulation of SCAR/WAVE function remain unclear.
The ARP2/3 complex: giving plant cells a leading edge.
Review
Mathur, Guelph, Canada. In Bioessays, 2005
The findings supporting a global conservation of molecular mechanisms for membrane protrusion have been further strengthened by the identification of plant homologs of upstream regulators of the complex such as PIR121, NAP125 and HSPC300.
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.
Impact
Kirschner et al., Boston, United States. In Nature, 2002
WAVE1 exists in a heterotetrameric complex that includes orthologues of human PIR121 (p53-inducible messenger RNA with a relative molecular mass (M(r)) of 140,000), Nap125 (NCK-associated protein with an M(r) of 125,000) and HSPC300.
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