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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Heat shock 70kDa protein 4

HSP70
Top mentioned proteins: CAN, Hsp90, HAD, V1a, ACID
Papers using HSP70 antibodies
Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.
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Cai Huaibin, In PLoS ONE, 2009
... (D88H11) CAT# 4180, anti-Atg7 CAT# 2631, anti-LC3B (D11) XP CAT# 3868, anti-mTOR (7C10) CAT# 2983, anti-Hsp70 CAT# 4872, anti-Hsp90β CAT# 5087, from Cell Signaling Technology, Inc ...
Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.
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Zimmer Jacques, In PLoS ONE, 2006
... for FACS and blocking experiments; BH1-2A as anti-NKp30 isotype control (kindly provided by Lemke, Kiel), anti-Hsp70 (WB-analysis-SPA810, Biomol, Hamburg, Germany), anti-LAMP2b (WB-analysis-ab18529, ...
EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin.
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Neyrolles Olivier, In PLoS ONE, 2006
... The following antibodies were used: anti-p65 (Santa-Cruz, Heidelberg, Germany), anti-Hsp70 (BD Biosciences & Assay Designs, Ann ...
Association of MBP peptides with Hsp70 in normal appearing human white matter
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Eiz-Vesper Britta et al., In Journal of Translational Medicine, 2005
... For the experiment, 33 mg mg purified HSP70 were conjugated with FITC (Fluoro tag FITC conjugation Kit, Sigma-Aldrich, Hamburg, Germany) as well as using FITC-labeled HLA-A*02:01-restricted CMVpp65495-503 peptide (CMV[FITC], GL Biochem) in a complex with HSP70 ...
Insulin inhibits platelet-derived growth factor-induced cell proliferation
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Friedmann Theodore et al., In Proteome Science, 2004
... Rad50, enolase, IκBKb and RhoGDI were from Santa Cruz Biotechnology (Santa Cruz, CA) and the Hsp70 antibody was from BD Biosciences (San Jose, CA) ...
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Papers on HSP70
The impact of genetic factors on response to glucocorticoids therapy in IBD.
New
Dobrowolska et al., Poznań, Poland. In Scand J Gastroenterol, Feb 2016
To those genes belong: NR3C1 - responsible for the synthesis of GC receptor (GR); Hsp90, HSP70, STIP1, FKB5 - genes of GR protein complex; ABCB1 and IPO13 coding glycoprotein p170; and importin 13 - involved in GCs transport; IL1A, IL1B, IL2, IL4, IL8, IL10, TNF, and MIF - genes of the epithelial pro-inflammatory factors synthesis, which excessive activation causes steroid resistance as well as CYP3A4 and CYP3A5 - encoding GCs biotransformation enzymes.
Recent progress in therapeutic strategy for ischemic stroke.
New
Abe et al., In Cell Transplant, Feb 2016
First, we studied temporal and spatial expression pattern of c-fos, hypoxia inducible factor-1α (HIF-1α), heat shock protein 70 (HSP70), and annexin V after 90 min of transient middle cerebral occlusion in rats, and concluded that there is a time window for neuroprotection from 12 to 48 h after ischemia.
Novel players in β-thalassemia dyserythropoiesis and new therapeutic strategies.
New
Courtois et al., Paris, France. In Curr Opin Hematol, Feb 2016
Blocking GDF11 alleviates anemia in a mouse model of β-thalassemia and also in humans, most likely by promoting cells of 'good' erythroblastic lineage containing an α-/non-α-globin chain ratio of close to 1. Maturation arrest at the polychromatophilic stage (step 3) is associated with the depletion of GATA binding protein 1 (GATA-1) from the nucleus, which results from cytoplasmic sequestration of heat shock protein 70 (HSP70) by α-globin chains.
Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin Resistance.
Review
New
Manucha et al., Mendoza, Argentina. In Curr Hypertens Rep, Jan 2016
Moreover, reduced NO release induces heat shock protein 70 kDa (HSP70) expression in IR and diabetes, mediating beneficial effects against oxidative stress injury, inflammation and apoptosis.
[Role of Heat Shock Protein 70 in Retinitis Pigmentosa and a Novel Strategy for Treatment].
Review
New
Furukawa et al., Suzuka, Japan. In Brain Nerve, Dec 2015
Heat shock protein 70 (HSP70) has been shown to function as a chaperone molecule that protects cells against environmental and physiological stresses.
Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
New
Impact
Bukau et al., Heidelberg, Germany. In Nature, Sep 2015
However, metazoans lack the key heat-shock protein disaggregase HSP100 of non-metazoan HSP70-dependent protein disaggregation systems, and the human HSP70 system alone, even with the crucial HSP110 nucleotide exchange factor, has poor disaggregation activity in vitro.
[The role of heat shock protein 70 in regulating neuroinflammation].
Review
New
Zhang et al., In Yao Xue Xue Bao, Aug 2015
Heat shock protein 70 (HSP70) is originally described as intracellular chaperone, which plays an important role in protein quality control in cells.
miRNA-mediated regulation of heat shock proteins in human ejaculated spermatozoa.
Hui et al., In Turk J Med Sci, 2014
Results: HSP40, HSP60, HSP70, and HSP90 were all found to be expressed in human ejaculated spermatozoa.
[The Concept of Immunogenic Cell Death in Antitumor Immunity].
Review
Špíšek et al., In Klin Onkol, 2014
The immunogenic characteristics of immunogenic cell death are mainly mediated by damage-associated molecular patterns represented by preapoptotic exposure of calreticulin and heat shock proteins (HSP70 and HSP90) from endoplasmic reticulum at the cell surface and active secretion of adenosintriphospate.
RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.
Review
Arroyo et al., Mexico. In Biomolecules, 2014
The tvcp4 and tvcp12 mRNAs have a stem-loop structure in the 5'-coding region or in the 3'-UTR, respectively that interacts with T. vaginalis multifunctional proteins HSP70, α-Actinin, and Actin under iron starvation condition, causing translation inhibition or mRNA stabilization similar to the previously characterized IRE-IRP system in eukaryotes.
Heat shock protein 70 polymorphisms in Chinese patients with Graves' disease.
Jin et al., Kunming, China. In Genet Mol Res, 2014
However, the correlation between the development of GD and HSP70 alleles has not been reported in the Chinese population.
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia.
Impact
Courtois et al., Paris, France. In Nature, 2014
We have shown that, in human erythroblasts, the chaperone heat shock protein70 (HSP70) is constitutively expressed and, at later stages of maturation, translocates into the nucleus and protects GATA-1 from caspase-3 cleavage.
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
Impact
Youle et al., Bethesda, United States. In Nature, 2014
We also discovered that HSPA1L (HSP70 family member) and BAG4 have mutually opposing roles in the regulation of parkin translocation.
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.
Impact
Casanova et al., New York City, United States. In Immunity, 2013
SEFIR-independent interactions of ACT1 with other proteins, such as CD40, heat shock protein 70 (HSP70) and HSP90, were not affected by the T536I mutation.
Chaperone machines for protein folding, unfolding and disaggregation.
Review
Impact
Saibil, London, United Kingdom. In Nat Rev Mol Cell Biol, 2013
The structural basis of their mechanism of action is being unravelled (in particular for the heat shock proteins HSP60, HSP70, HSP90 and HSP100) and typically involves massive displacements of 20-30 kDa domains over distances of 20-50 Å and rotations of up to 100°.
DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
GeneRIF
Dickey et al., Tampa, United States. In J Mol Biol, 2012
Moreover, the levels of DnaJA1 and Hsp70 seem to play against each other with regard to tau: as DnaJA1 levels increase, tau levels are reduced, but this can be prevented if Hsp70 levels are simultaneously induced.
Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells.
GeneRIF
Darie et al., United States. In Febs J, 2012
Studies suggest that GRP78, and perhaps HSP70s, are strong tumor differentiation factor receptor candidates.
Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia.
GeneRIF
Srinivasan et al., Chennai, India. In Toxicol Mech Methods, 2012
Protective role of chaperones (HSP70 and 90) in preeclampsia.
Hsp70 protein positively regulates rabies virus infection.
GeneRIF
Blondel et al., Gif-sur-Yvette, France. In J Virol, 2012
Hsp70 has a proviral function during rabies virus infection and suggest that Hsp70 is involved in at least one stage(s) of the viral life cycle, such as viral transcription, translation, and/or production.
The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.
GeneRIF
Hu et al., Shanghai, China. In J Biol Chem, 2012
an alternative mechanism of allosteric activation for functional regulation of HSP70 by its J-domain co-chaperones
More papers using HSP70 antibodies
Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response
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Burzyński Marek et al., In Journal of Experimental Botany, 2003
anti-HSP70, and anti-HSP101 (Agrisera).
Human keratinocytes respond to osmotic stress by p38 map kinase regulated induction of HSP70 and HSP27
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Szilard John et al., In Journal of Biomedicine and Biotechnology, 2000
... (cat number) SI00042462, cat number SI00025263, Qiagen, Hombrechtikon, Switzerland] or with siRNA for Hsp40 and Hsp70 (Qiagen), the final concentration of ...
Insights into the function of Hsp70 chaperones
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Tukaj Zbigniew et al., In Bulletin of Environmental Contamination and Toxicology, 2000
... and HSP70 synthesis; b) cadmium (CdCl2*H2O, analytical grade; Merck, Germany) was dissolved in ...
Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment
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Kim Seok Hyeon et al., In Psychiatry Investigation, 1999
... Louis, MO, USA), and the antibody for HSP70 was obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4
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Humphries Martin J. et al., In The Journal of Cell Biology, 1999
... Mouse monoclonal antibodies raised against p190-A and phosphotyrosine (4G10; Millipore), vinculin (Sigma-Aldrich), HSP70 (Affinity BioReagents), PKCα (BD Biosciences), and transferrin receptor (Invitrogen); ...
Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
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Jäättelä Marja et al., In The Journal of Experimental Medicine, 1988
... Murine embryonic fibroblasts (MEFs) explanted from days 14–16 wild type or homozygote Hsp70 transgenic CBA × C57Bl/6 mice ...
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