Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.more suppliers
In PLoS ONE, 2009
... (D88H11) CAT# 4180, anti-Atg7 CAT# 2631, anti-LC3B (D11) XP CAT# 3868, anti-mTOR (7C10) CAT# 2983, anti-Hsp70 CAT# 4872, anti-Hsp90β CAT# 5087, from Cell Signaling Technology, Inc ...
The impact of genetic factors on response to glucocorticoids therapy in IBD.
Poznań, Poland. In Scand J Gastroenterol, Feb 2016
To those genes belong: NR3C1 - responsible for the synthesis of GC receptor (GR); Hsp90, HSP70, STIP1, FKB5 - genes of GR protein complex; ABCB1 and IPO13 coding glycoprotein p170; and importin 13 - involved in GCs transport; IL1A, IL1B, IL2, IL4, IL8, IL10, TNF, and MIF - genes of the epithelial pro-inflammatory factors synthesis, which excessive activation causes steroid resistance as well as CYP3A4 and CYP3A5 - encoding GCs biotransformation enzymes.
Recent progress in therapeutic strategy for ischemic stroke.
In Cell Transplant, Feb 2016
First, we studied temporal and spatial expression pattern of c-fos, hypoxia inducible factor-1α (HIF-1α), heat shock protein 70 (HSP70), and annexin V after 90 min of transient middle cerebral occlusion in rats, and concluded that there is a time window for neuroprotection from 12 to 48 h after ischemia.
Novel players in β-thalassemia dyserythropoiesis and new therapeutic strategies.
Paris, France. In Curr Opin Hematol, Feb 2016
Blocking GDF11 alleviates anemia in a mouse model of β-thalassemia and also in humans, most likely by promoting cells of 'good' erythroblastic lineage containing an α-/non-α-globin chain ratio of close to 1. Maturation arrest at the polychromatophilic stage (step 3) is associated with the depletion of GATA binding protein 1 (GATA-1) from the nucleus, which results from cytoplasmic sequestration of heat shock protein 70 (HSP70) by α-globin chains.
Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
Heidelberg, Germany. In Nature, Sep 2015
However, metazoans lack the key heat-shock protein disaggregase HSP100 of non-metazoan HSP70-dependent protein disaggregation systems, and the human HSP70 system alone, even with the crucial HSP110 nucleotide exchange factor, has poor disaggregation activity in vitro.
RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.
Mexico. In Biomolecules, 2014
The tvcp4 and tvcp12 mRNAs have a stem-loop structure in the 5'-coding region or in the 3'-UTR, respectively that interacts with T. vaginalis multifunctional proteins HSP70, α-Actinin, and Actin under iron starvation condition, causing translation inhibition or mRNA stabilization similar to the previously characterized IRE-IRP system in eukaryotes.
[The Concept of Immunogenic Cell Death in Antitumor Immunity].
In Klin Onkol, 2014
The immunogenic characteristics of immunogenic cell death are mainly mediated by damage-associated molecular patterns represented by preapoptotic exposure of calreticulin and heat shock proteins (HSP70 and HSP90) from endoplasmic reticulum at the cell surface and active secretion of adenosintriphospate.
Chaperone machines for protein folding, unfolding and disaggregation.
London, United Kingdom. In Nat Rev Mol Cell Biol, 2013
The structural basis of their mechanism of action is being unravelled (in particular for the heat shock proteins HSP60, HSP70, HSP90 and HSP100) and typically involves massive displacements of 20-30 kDa domains over distances of 20-50 Å and rotations of up to 100°.
Hsp70 protein positively regulates rabies virus infection.
More papers using
Gif-sur-Yvette, France. In J Virol, 2012
Hsp70 has a proviral function during rabies virus infection and suggest that Hsp70 is involved in at least one stage(s) of the viral life cycle, such as viral transcription, translation, and/or production.