The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.
United States. In J Biol Chem, 04 Jan 2015
Screening a focused library of compounds containing redox-directed electrophilic pharmacophores employing the Stress & Toxicity PathwayFinderTM PCR-array technology as a discovery tool, a drug-like triphenylmethane-derivative [aurin; 4-[bis(p-hydroxyphenyl)methylene]-2,5-cyclohexadien-1-one] was identified as an experimental cell stress modulator that causes (i) heat shock factor transcriptional activation, (ii) upregulation of heat shock response gene expression (HSPA6, HSPA1A, DNAJB4, HMOX1), (iii) early unfolded protein response (UPR) signaling (phospho-PERK, phospho-eIF2α, CHOP), (iv) proteasome impairment with increased protein-ubiquitination, and (v) oxidative stress with glutathione depletion.
234 new culture media affects blastocyst development and gene expression levels in in vitro-produced bovine embryos.
Copenhagen, Denmark. In Reprod Fertil Dev, 31 Dec 2014
The high-quality blastocysts from each group were analysed by RT-qPCR, on single blastocysts using earlier verified primers, for BAX, BCL2L1, DNMT3A, FASN, G6PD, HSPA1A, SLC2A1, and SLC2A3.
Transcriptome Analysis of the Human Corneal Endothelium.
Los Angeles, United States. In Invest Ophthalmol Vis Sci, 06 Dec 2014
Nine genes displayed the most significant differential expression between pediatric and adult HCEnC: CAPN6, HIST1H3A, HIST1H4E and HSPA2 were expressed at higher levels in pediatric HCEnC, while ITGBL1, NALCN, PREX2, TAC1 and TMOD1 were expressed at higher levels in adult HCEnC.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Hastings, United Kingdom. In Schizophr Bull, 2009
Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE).