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Heat shock protein 2

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, HAD, POLYMERASE, AGE
Papers using HSP70-2 antibodies
Hsp70-2 is required for tumor cell growth and survival
O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal antibody to HSPA2 (ab55290) was purchased from Abcam Inc ...
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
Okada Hitoshi et al., In The Journal of Cell Biology, 1998
... ), Hsp70-2/HspA2 (M06; Abnova Corp.), calretinin (Santa Cruz ...
Papers on HSP70-2
Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes.
Jacobs et al., Hilo, United States. In Pharm Biol, Feb 2016
FKA and FKB also activated HSF1, increasing HSPA1A and DNAJA4 expression.
Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
Ghayour-Mobarhan et al., Mashhad, Iran. In Ann Hum Biol, Feb 2016
Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however there are little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.
Proteomic signatures of infertile men with clinical varicocele and their validation studies reveal mitochondrial dysfunction leading to infertility.
Sabanegh et al., Cleveland, United States. In Asian J Androl, Jan 2016
Expression levels of 5 key proteins (PKAR1A, AK7, CCT6B, HSPA2, and ODF2) involved in stress response and sperm function including molecular chaperones were validated by Western blotting.
Evaluation of mRNA markers for estimating blood deposition time: Towards alibi testing from human forensic stains with rhythmic biomarkers.
Kayser et al., Rotterdam, Netherlands. In Forensic Sci Int Genet, Jan 2016
We found that although in general mRNA-based estimation of time categories was less accurate than hormone-based estimation, the use of three mRNA markers HSPA1B, MKNK2 and PER3 together with melatonin and cortisol generally enhanced the time prediction accuracy relative to the use of the two hormones alone.
Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa.
Nixon et al., Newcastle, Australia. In Mol Hum Reprod, Jan 2016
STUDY HYPOTHESIS: Given the importance of the chaperone Heat Shock Protein A2 (HSPA2) in the regulation of male fertility, this study aimed to identify and characterize additional proteins that may rely on the activity of this chaperone in human spermatozoa.
Testis-enriched heat shock protein A2 (HSPA2): Adaptive advantages of the birds with internal testes over the mammals with testicular descent.
Ma et al., College Park, United States. In Sci Rep, Dec 2015
The molecular chaperone heat shock protein A2 (HSPA2), a member of the 70 kDa heat shock protein (HSP70) family, plays an important role in spermatogenesis and male fertility.
Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping.
Barbe et al., Philadelphia, United States. In Bmc Musculoskelet Disord, Dec 2015
The aim of this study was to evaluate: 1) OA expression in an operant rat model of repetitive overuse; 2) expression of MMPs; 3) inflammatory cytokines indicative of injury or inflammation; and 4) the inducible form of heat shock protein 70 (HSPA1A/HSP72) as the latter is known to increase during metabolic stress and to be involved in cellular repair.
Effects of Sequence Variations in Innate Immune Response Genes on Infectious Outcome in Trauma Patients: A Comprehensive Review.
Van Lieshout et al., Rotterdam, Netherlands. In Shock, Nov 2015
The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA.
Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy.
Witkin et al., New York City, United States. In Cell Stress Chaperones, Sep 2015
A consequence of hsp70 (HSPA1A) induction is the inhibition of autophagy.
The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.
Aitken et al., Newcastle, Australia. In Asian J Androl, Jul 2015
HSPA2 is a testis-enriched member of the 70 kDa heat shock protein family that promotes the folding, transport, and assembly of protein complexes and has been positively correlated with in vitro fertilization (IVF) success.
Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans.
Krawczyk et al., Gliwice, Poland. In Cell Stress Chaperones, Mar 2015
The HSPA2 gene is a poorly characterized member of the HSPA (HSP70) family.
Association of Plasma Heat Shock Protein 70, Interleukin 6, and Creatine Kinase Concentrations in a Healthy, Young Adult Population.
Deuster et al., Bethesda, United States. In J Biomark, 2014
Mean protein levels of CK, HSP70, and IL-6 were compared by sex, ethnicity, genetic variants-CKMM Nco1 (rs1803285), HSPA1B +A1538G (rs1061581), and IL6 G-174C (rs1800795)-self-reported history of exercise, oral contraceptive use, and dietary supplement use.
Heat shock protein 70 polymorphisms in Chinese patients with Graves' disease.
Jin et al., Kunming, China. In Genet Mol Res, 2014
HSP70 polymorphisms at positions HSP70-1 +190, HSP70-2 +1267, and HSP70-hom +2437 were genotyped by polymerase chain reaction-restriction fragment length polymorphism.
Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones.
Goloubinoff et al., Lausanne, Switzerland. In Front Mol Biosci, 2014
The heat-inducible form HSP70 (HSPA1A) and its major cognates, cytosolic HSC70 (HSPA8), endoplasmic reticulum BIP (HSPA5), mitochondrial mHSP70 (HSPA9) and related HSP110s (HSPHs), contribute about 3% of the total protein mass of human cells.
Differential expression of heat shock protein (HSP) 70-2 gene polymorphism in benign and malignant pancreatic disorders and its relationship with disease severity and complications.
Gupta et al., Chandīgarh, India. In Jop, 2012
significantly higher frequency of HSP 70-2 gene mutant allele (G allele) in patients with acute pancreatitis and pancreatic carcinoma as compared to control population.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
Müller et al., Budapest, Hungary. In Cancer Invest, 2012
Decreased expression of HSP72 was at least partly the result of HSP72 [HSPA1B A(1267)G] gene polymorphism in small cell lung cancer
HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.
Scieglinska et al., Gliwice, Poland. In Biochem Cell Biol, 2012
In somatic cells HSPA2 can be a part of a system protecting cells against cytotoxic stimuli inducing proteotoxic stress.
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
Fontenay et al., Paris, France. In Blood, 2012
Data show that expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues Expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues myelodysplastic syndromes erythroid cell differentiation.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
Wu et al., China. In Cancer Res, 2012
Fndings show that the HSPA1B variants are associated with lung cancer risk and survival.
Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance.
Saito et al., Kyoto, Japan. In Nat Biotechnol, 2001
Furthermore, this assay was found applicable for the detection of SNP existing in PCR amplification products of a 652-nucleotide sequence of the HSP70-2 gene.
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