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Heat shock protein 2

HSP70-2, HSPA2, HSPA1B, HSPA1A
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, HAD, POLYMERASE, AGE
Papers using HSP70-2 antibodies
Hsp70-2 is required for tumor cell growth and survival
Supplier
O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal antibody to HSPA2 (ab55290) was purchased from Abcam Inc ...
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
Supplier
Okada Hitoshi et al., In The Journal of Cell Biology, 1998
... ), Hsp70-2/HspA2 (M06; Abnova Corp.), calretinin (Santa Cruz ...
Papers on HSP70-2
Expression profiling of major heat shock protein genes during different seasons in cattle (Bos indicus) and buffalo (Bubalus bubalis) under tropical climatic condition.
New
Upadhyay et al., Karnāl, India. In J Therm Biol, 31 Jul 2015
Quantitative real time polymerase chain reaction was performed to analyze the transcript variants of three HSP70 family genes (HSPA1A, HSPA1B, and HSPA8) and HSP10, HSP60, HSP90 and HSF1 in each breed.
Heat shock decreases the embryonic quality of frozen-thawed bovine blastocysts produced in vitro.
New
Sakatani et al., Fukuoka, Japan. In J Reprod Dev, 21 Jul 2015
HSPA1A expression as a reflection of stress was increased by heat shock (P<0.05),
Treatment of textile wastewater by submerged membrane bioreactor: In vitro bioassays for the assessment of stress response elicited by raw and reclaimed wastewater.
New
Sayadi et al., Sfax, Tunisia. In J Environ Manage, 21 Jul 2015
Moreover, the effect of RTWW and treated wastewater on stress response was investigated using different stress genes: AHSA1, HSPD1, HSPA1A, HSPA5 and HSPA8.
Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy.
New
Witkin et al., New York City, United States. In Cell Stress Chaperones, 18 Jul 2015
UNASSIGNED: A consequence of hsp70 (HSPA1A) induction is the inhibition of autophagy.
Transcription factor FOXA2-centered transcriptional regulation network in non-small cell lung cancer.
New
Choi et al., Seoul, South Korea. In Biochem Biophys Res Commun, 17 Jul 2015
Additionally, the proteins including highly similar to heat shock protein HSP 90-beta (HSP90A), heat shock 70kDa protein 1A variant (HSPA1A), histone deacetylase 1 (HDAC1) and HDAC3 were identified as novel interacting partners of FOXA2.
Polyglutamine aggregation in Huntington's disease and Spinocerebellar Ataxia type 3: similar mechanisms in aggregate formation.
New
den Dunnen et al., Frankfurt am Main, Germany. In Neuropathol Appl Neurobiol, 11 Jul 2015
A subset of neurons with intranuclear inclusions bodies exhibited signs of proteasomal dysfunction, up-regulation of HSPA1A and re-distribution of DNAJB1.
Early inflammatory response in polytraumatized patients: Cytokines and heat shock proteins. A pilot study.
New
Vaquero et al., Madrid, Spain. In Orthop Traumatol Surg Res, 08 Jul 2015
The objectives of this study were to analyze if some inflammatory mediators can be considered prognostic biomarkers of outcome, and the possible role of HSPA1A in posttraumatic immunosuppression.
Acute heat stress induces differential gene expressions in the testes of a broiler-type strain of taiwan country chickens.
New
Huang et al., T'ai-chung-shih, Taiwan. In Plos One, Dec 2014
The mRNA expressions of upregulated genes, including HSP25, HSP90AA1, HSPA2, and LPAR2, and of downregulated genes, including CDH5, CTNNA3, EHF, CIRBP, SLA, and NTF3, were confirmed through quantitative real-time polymerase chain reaction (qRT-PCR).
Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones.
Review
New
Goloubinoff et al., Lausanne, Switzerland. In Front Mol Biosci, Dec 2014
The heat-inducible form HSP70 (HSPA1A) and its major cognates, cytosolic HSC70 (HSPA8), endoplasmic reticulum BIP (HSPA5), mitochondrial mHSP70 (HSPA9) and related HSP110s (HSPHs), contribute about 3% of the total protein mass of human cells.
Mining the key regulatory genes of chicken inosine 5'-monophosphate metabolism based on time series microarray data.
New
Chen et al., Yangzhou, China. In J Anim Sci Biotechnol, Dec 2014
We found 15 crucial co-expression genes, which are Hspa2, Pten, Gabpa, Bpi, Mkl1, Srf, Cd34, Hspa4, Etv6, Bmpr2, Gde1, Igfbp5, Cd28, Pecam1 and Gja1, that may directly or indirectly regulate IMP metabolism.
Differential expression of heat shock protein (HSP) 70-2 gene polymorphism in benign and malignant pancreatic disorders and its relationship with disease severity and complications.
GeneRIF
Gupta et al., Chandīgarh, India. In Jop, 2012
significantly higher frequency of HSP 70-2 gene mutant allele (G allele) in patients with acute pancreatitis and pancreatic carcinoma as compared to control population.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
GeneRIF
Müller et al., Budapest, Hungary. In Cancer Invest, 2012
Decreased expression of HSP72 was at least partly the result of HSP72 [HSPA1B A(1267)G] gene polymorphism in small cell lung cancer
HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.
GeneRIF
Scieglinska et al., Gliwice, Poland. In Biochem Cell Biol, 2012
In somatic cells HSPA2 can be a part of a system protecting cells against cytotoxic stimuli inducing proteotoxic stress.
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
GeneRIF
Fontenay et al., Paris, France. In Blood, 2012
Data show that expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues Expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues myelodysplastic syndromes erythroid cell differentiation.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
GeneRIF
Wu et al., Taiwan. In Cancer Res, 2012
Fndings show that the HSPA1B variants are associated with lung cancer risk and survival.
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.
Review
Hightower et al., München, Germany. In Cell Stress Chaperones, 2011
In this review, we will focus on Hsp70 (HSPA1A), the major stress-inducible member of the human Hsp70 family.
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Review
Rigó et al., Budapest, Hungary. In Cell Stress Chaperones, 2010
However, Hsp70 (HSPA1A) is present in the peripheral circulation of healthy nonpregnant and pregnant individuals.
Genetic risk for recurrent urinary tract infections in humans: a systematic review.
Review
Fanos et al., Verona, Italy. In J Biomed Biotechnol, 2009
In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Review
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE).
Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance.
Impact
Saito et al., Kyoto, Japan. In Nat Biotechnol, 2001
Furthermore, this assay was found applicable for the detection of SNP existing in PCR amplification products of a 652-nucleotide sequence of the HSP70-2 gene.
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