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Heat shock protein 2

HSP70-2, HSPA2, HSPA1B, HSPA1A
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, HAD, POLYMERASE, AGE
Papers using HSP70-2 antibodies
Hsp70-2 is required for tumor cell growth and survival
Supplier
O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal antibody to HSPA2 (ab55290) was purchased from Abcam Inc ...
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
Supplier
Okada Hitoshi et al., In The Journal of Cell Biology, 1998
... ), Hsp70-2/HspA2 (M06; Abnova Corp.), calretinin (Santa Cruz ...
Papers on HSP70-2
Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?
New
Bergamaschi et al., Pavia, Italy. In J Neuroimmunol, 15 Apr 2014
We focused our attention on HSP70-2, an inducible chaperon induced under stress conditions.
Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.
New
Espejo et al., Barcelona, Spain. In Autoimmunity, 31 Mar 2014
Abstract Inducible heat shock protein (HSP)70 (HSP70-1A and HSP70-1B proteins) is a chaperone responsible for assisting proper protein folding.
SHCBP1L, a conserved protein in mammals, is predominantly expressed in male germ cells and maintains spindle stability during meiosis in testis.
New
Sha et al., Nanjing, China. In Mol Hum Reprod, 20 Mar 2014
Using this model, we showed that SHCBP1L binds to another protein, HSPA2, and maintains stability of the spindle.
Post-maturation zona perforation improves porcine parthenogenetic trophoblast culture.
New
Lee et al., Seoul, South Korea. In Placenta, 18 Mar 2014
Quantitative real-time PCR analysis showed significant differences in BAX, BAX/BCL2L1 and HSP70-2 mRNA expression between the experimental groups.
Expressions of miR-15a and its target gene HSPA1B in spermatozoa of patients with varicocele.
New
Cai et al., Shenzhen, China. In Reproduction, 02 Mar 2014
Furthermore, miR-15a repressed the expression of HSPA1B, which is a typical stress-induced chaperone protein, through directly binding its 3'UTR.
Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
New
Gestwicki et al., Ann Arbor, United States. In J Biol Chem, 17 Feb 2014
Toward these questions, we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105.
Nucleolin involved in myocardial ischemic preconditioning via posttranscriptional control of HSPA1A expression.
New
Xiao et al., Changsha, China. In Cardiovasc Res, 16 Feb 2014
On the other hand, nucleolin overexpression increased the stabilization of the HSPA1A mRNA and the expression of HSPA1A protein in cardiomyocytes, while nucleolin ablation abrogated the upregulation of HSPA1A induced by H2O2-PC in cardiomyocytes.
Association of HSPA1B SNP rs6457452 with Alopecia Areata in the Korean Population.
New
Sim et al., Seoul, South Korea. In Immunol Invest, Dec 2013
The heat shock 70 kDa protein 1B (HSPA1B), which has been well-studied among the famous heat shock proteins HSPA1A/B/L, is related to autoimmune diseases, including Alopecia Areata (AA).
Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness.
Weickert et al., Sydney, Australia. In Sci Rep, 2012
There were no diagnostic differences in steady-state FKBP51 protein levels, nor in HSPA1A, HSP90AA1, DNAJB1 or HSPB1 mRNA levels.
Differential expression of heat shock protein (HSP) 70-2 gene polymorphism in benign and malignant pancreatic disorders and its relationship with disease severity and complications.
GeneRIF
Gupta et al., Chandīgarh, India. In Jop, 2012
significantly higher frequency of HSP 70-2 gene mutant allele (G allele) in patients with acute pancreatitis and pancreatic carcinoma as compared to control population.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
GeneRIF
Müller et al., Budapest, Hungary. In Cancer Invest, 2012
Decreased expression of HSP72 was at least partly the result of HSP72 [HSPA1B A(1267)G] gene polymorphism in small cell lung cancer
HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.
GeneRIF
Scieglinska et al., Gliwice, Poland. In Biochem Cell Biol, 2012
In somatic cells HSPA2 can be a part of a system protecting cells against cytotoxic stimuli inducing proteotoxic stress.
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
GeneRIF
Fontenay et al., Paris, France. In Blood, 2012
Data show that expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues Expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues myelodysplastic syndromes erythroid cell differentiation.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
GeneRIF
Wu et al., China. In Cancer Res, 2012
Fndings show that the HSPA1B variants are associated with lung cancer risk and survival.
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.
Review
Hightower et al., München, Germany. In Cell Stress Chaperones, 2011
In this review, we will focus on Hsp70 (HSPA1A), the major stress-inducible member of the human Hsp70 family.
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Review
Rigó et al., Budapest, Hungary. In Cell Stress Chaperones, 2010
However, Hsp70 (HSPA1A) is present in the peripheral circulation of healthy nonpregnant and pregnant individuals.
Genetic risk for recurrent urinary tract infections in humans: a systematic review.
Review
Fanos et al., Verona, Italy. In J Biomed Biotechnol, 2009
In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Review
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE).
Fertility testing and ICSI sperm selection by hyaluronic acid binding: clinical and genetic aspects.
Review
Ozkavukcu et al., New Haven, United States. In Reprod Biomed Online, 2007
The testis-expressed chaperone protein, HspA2 (previously creatine kinase M isoform) was established as a measure of human sperm cellular maturity, function and fertility.
Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance.
Impact
Saito et al., Kyoto, Japan. In Nat Biotechnol, 2001
Furthermore, this assay was found applicable for the detection of SNP existing in PCR amplification products of a 652-nucleotide sequence of the HSP70-2 gene.
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