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Heat shock protein 2

HSP70-2, HSPA2, HSPA1B, HSPA1A
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, HAD, POLYMERASE, AGE
Papers using HSP70-2 antibodies
Hsp70-2 is required for tumor cell growth and survival
Supplier
O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal antibody to HSPA2 (ab55290) was purchased from Abcam Inc ...
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
Supplier
Okada Hitoshi et al., In The Journal of Cell Biology, 1998
... ), Hsp70-2/HspA2 (M06; Abnova Corp.), calretinin (Santa Cruz ...
Papers on HSP70-2
Localization of heat shock protein HSPA6 (HSP70B') to sites of transcription in cultured differentiated human neuronal cells following thermal stress.
New
Brown et al., Toronto, Canada. In J Neurochem, 15 Nov 2014
In order to identify potential stress-sensitive sites in differentiated SH-SY5Y human neuronal cells, localization of two inducible members of the HSPA (HSP70) family was investigated, namely HSPA6 (HSP70B') and HSPA1A (HSP70-1).
Depression of HspA2 in human testis is associated with spermatogenic impairment and fertilization rate in ICSI treatment for azoospermic individuals.
New
Xu et al., Hangzhou, China. In J Assist Reprod Genet, 12 Nov 2014
PURPOSE: Heat shock protein A2 (HspA2) expression was quantitatively measured in human testis and its relationship with the spermatogenetic status and laboratory outcomes of intracytoplasmic sperm injection (ICSI) was investigated.
Reporter Mice Express Green Fluorescent Protein at Initiation of Meiosis in Spermatocytes.
New
Eddy et al., Lyon, France. In Genesis, 08 Nov 2014
UNLABELLED: Transgenic mice were generated using a heat shock protein 2 (Hspa2) gene promoter to express green fluorescent protein (GFP) at the beginning of meiotic prophase I in spermatocytes.
TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.
New
Calderwood et al., Boston, United States. In Nat Struct Mol Biol, 31 Oct 2014
An unbiased search for new human proteins that could regulate paused Pol II at the HSPA1B gene identified TRIM28.
Polymorphism of heat shock protein 70-2 and enterocutaneous fistula in Chinese population.
New
Li et al., Nanjing, China. In World J Gastroenterol, 21 Oct 2014
AIM: To investigate whether the heat shock protein 70-2 (HSP70-2) polymorphism is associated with enterocutaneous fistulas in a Chinese population.
Integrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on non-fibrotic livers.
New
Chevet et al., Bordeaux, France. In Mol Cell Proteomics, 15 Oct 2014
The functional analysis of the two data sets pointed towards the deregulation of a protein homeostasis (proteostasis) network including the upregulation of the Endoplasmic Reticulum (ER) resident HSPA5, HSP90B1, PDIA6 and P4HB and of the cytosolic HSPA1B, HSP90AA1, HSPA9, UBC, CNDP2, TXN and VCP as well as the increased phosphorylation of the ER resident calnexin at Ser583.
Targeting the testis-specific heat-shock protein 70-2 (HSP70-2) reduces cellular growth, migration, and invasion in renal cell carcinoma cells.
New
Suri et al., New Delhi, India. In Tumour Biol, 12 Oct 2014
Testis-specific heat-shock protein 70-2 (HSP70-2), a member of HSP70 chaperone family, has been shown to be associated with various cancers.
Expression of stress-dependent genes in hepatocytes spheroids after Cisplatin treatment.
New
Shkurnikov et al., Moscow, Russia. In Bull Exp Biol Med, 30 Sep 2014
An increase in expression of genes of GSR and HSPA1A proteins at the early stages of incubation with cisplatin can serve as a marker of the cytotoxic effects of cisplatin and other agents with similar mechanisms of action.
Association between the HSPA1B ±1267A/G polymorphism and cancer risk: a meta-analysis of 14 case-control studies.
New
Tang et al., Chengdu, China. In Asian Pac J Cancer Prev, Dec 2013
Overall, the results indicated that the G allele of HSPA1B gene ±1267A/G was significantly associated with an increased cancer risk in all genetic models (G vs A: OR=1.51, 95%CI 1.17-1.95,
Differential expression of heat shock protein (HSP) 70-2 gene polymorphism in benign and malignant pancreatic disorders and its relationship with disease severity and complications.
GeneRIF
Gupta et al., Chandīgarh, India. In Jop, 2012
significantly higher frequency of HSP 70-2 gene mutant allele (G allele) in patients with acute pancreatitis and pancreatic carcinoma as compared to control population.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
GeneRIF
Müller et al., Budapest, Hungary. In Cancer Invest, 2012
Decreased expression of HSP72 was at least partly the result of HSP72 [HSPA1B A(1267)G] gene polymorphism in small cell lung cancer
HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.
GeneRIF
Scieglinska et al., Gliwice, Poland. In Biochem Cell Biol, 2012
In somatic cells HSPA2 can be a part of a system protecting cells against cytotoxic stimuli inducing proteotoxic stress.
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
GeneRIF
Fontenay et al., Paris, France. In Blood, 2012
Data show that expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues Expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues myelodysplastic syndromes erythroid cell differentiation.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
GeneRIF
Wu et al., China. In Cancer Res, 2012
Fndings show that the HSPA1B variants are associated with lung cancer risk and survival.
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.
Review
Hightower et al., München, Germany. In Cell Stress Chaperones, 2011
In this review, we will focus on Hsp70 (HSPA1A), the major stress-inducible member of the human Hsp70 family.
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Review
Rigó et al., Budapest, Hungary. In Cell Stress Chaperones, 2010
However, Hsp70 (HSPA1A) is present in the peripheral circulation of healthy nonpregnant and pregnant individuals.
Genetic risk for recurrent urinary tract infections in humans: a systematic review.
Review
Fanos et al., Verona, Italy. In J Biomed Biotechnol, 2009
In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Review
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE).
Fertility testing and ICSI sperm selection by hyaluronic acid binding: clinical and genetic aspects.
Review
Ozkavukcu et al., New Haven, United States. In Reprod Biomed Online, 2007
The testis-expressed chaperone protein, HspA2 (previously creatine kinase M isoform) was established as a measure of human sperm cellular maturity, function and fertility.
Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance.
Impact
Saito et al., Kyoto, Japan. In Nat Biotechnol, 2001
Furthermore, this assay was found applicable for the detection of SNP existing in PCR amplification products of a 652-nucleotide sequence of the HSP70-2 gene.
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