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Heat shock protein 2

HSP70-2, HSPA2, HSPA1B, HSPA1A
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, HAD, POLYMERASE, AGE
Papers using HSP70-2 antibodies
Hsp70-2 is required for tumor cell growth and survival
Supplier
O'Rand Michael G et al., In Reproductive Biology and Endocrinology : RB&E, 2004
... Mouse monoclonal antibody to HSPA2 (ab55290) was purchased from Abcam Inc ...
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis
Supplier
Okada Hitoshi et al., In The Journal of Cell Biology, 1998
... ), Hsp70-2/HspA2 (M06; Abnova Corp.), calretinin (Santa Cruz ...
Papers on HSP70-2
Expression profiling of major heat shock protein genes during different seasons in cattle (Bos indicus) and buffalo (Bubalus bubalis) under tropical climatic condition.
New
Upadhyay et al., Karnāl, India. In J Therm Biol, 31 Jul 2015
Quantitative real time polymerase chain reaction was performed to analyze the transcript variants of three HSP70 family genes (HSPA1A, HSPA1B, and HSPA8) and HSP10, HSP60, HSP90 and HSF1 in each breed.
The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.
New
Aitken et al., Newcastle, Australia. In Asian J Androl, 10 May 2015
HSPA2 is a testis-enriched member of the 70 kDa heat shock protein family that promotes the folding, transport, and assembly of protein complexes and has been positively correlated with in vitro fertilization (IVF) success.
Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs.
New
Goloubinoff et al., Lausanne, Switzerland. In Cell Stress Chaperones, 08 May 2015
Unexpectedly, heat-treated cells accumulated 55 times more new molecules of HSPA8 (HSC70) than of the acknowledged heat-inducible isoform HSPA1A (HSP70), implying that when expressed as net copy number differences, rather than as mere "fold change" ratios, new biologically relevant information can be extracted from quantitative proteomic data.
Activation of HSPA1A promoter by environmental pollutants: An early and rapid response to cellular damage.
New
Guo et al., Suzhou, China. In Environ Toxicol Pharmacol, 22 Apr 2015
UNASSIGNED: We established the HepG2-luciferase cells containing a luciferase reporter gene regulated by human HSPA1A promoter.
[Relationship between HSP70 gene polymorphisms and susceptibility to lung function injury of cock-oven workers].
New
Zheng et al., Taiyuan, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, Mar 2015
HSP70-1 G190C, HSP70-2 A1267G, HSP70- hom T2437C genotypes were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
Using the gene expression signature of scutebarbalactone VN isolated from Scutellaria barbata to elucidate its anticancer activities.
New
Minh et al., In Nat Prod Commun, Feb 2015
BalA also showed the potential to reactivate downregulated genes in hepatocellular carcinoma cells and genes in antioxidant pathways such as HMOX1 and HSPA1A.
Acute heat stress induces differential gene expressions in the testes of a broiler-type strain of taiwan country chickens.
New
Huang et al., T'ai-chung-shih, Taiwan. In Plos One, Dec 2014
The mRNA expressions of upregulated genes, including HSP25, HSP90AA1, HSPA2, and LPAR2, and of downregulated genes, including CDH5, CTNNA3, EHF, CIRBP, SLA, and NTF3, were confirmed through quantitative real-time polymerase chain reaction (qRT-PCR).
Copper excess in liver HepG2 cells interferes with apoptosis and lipid metabolic signaling at the protein level.
New
Gu et al., Changsha, China. In Turk J Gastroenterol, Dec 2014
Copper overload significantly induced the expression of HSPA1A (heat shock 70kDa protein 1A), an oxidative stress-responsive signal gene, and BAG3 (BCL2 associated athanogene3), an anti-apoptotic gene, while expression of HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase), a lipid biosynthesis and lipid metabolism gene, was inhibited.
Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma.
New
Zhang et al., Beijing, China. In Diagn Pathol, Dec 2014
BACKGROUND: It has been shown that heat shock-related 70-kDa protein 2 (HSPA2), a member of the HSP70 family of heat shock proteins, is important for cancer cell growth and metastasis.
Differential expression of heat shock protein (HSP) 70-2 gene polymorphism in benign and malignant pancreatic disorders and its relationship with disease severity and complications.
GeneRIF
Gupta et al., Chandīgarh, India. In Jop, 2012
significantly higher frequency of HSP 70-2 gene mutant allele (G allele) in patients with acute pancreatitis and pancreatic carcinoma as compared to control population.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
GeneRIF
Müller et al., Budapest, Hungary. In Cancer Invest, 2012
Decreased expression of HSP72 was at least partly the result of HSP72 [HSPA1B A(1267)G] gene polymorphism in small cell lung cancer
HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis.
GeneRIF
Scieglinska et al., Gliwice, Poland. In Biochem Cell Biol, 2012
In somatic cells HSPA2 can be a part of a system protecting cells against cytotoxic stimuli inducing proteotoxic stress.
Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.
GeneRIF
Fontenay et al., Paris, France. In Blood, 2012
Data show that expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues Expression of a nucleus-targeted mutant of Hsp70 protects GATA-1 and rescues myelodysplastic syndromes erythroid cell differentiation.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
GeneRIF
Wu et al., China. In Cancer Res, 2012
Fndings show that the HSPA1B variants are associated with lung cancer risk and survival.
Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies.
Review
Hightower et al., München, Germany. In Cell Stress Chaperones, 2011
In this review, we will focus on Hsp70 (HSPA1A), the major stress-inducible member of the human Hsp70 family.
Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.
Review
Rigó et al., Budapest, Hungary. In Cell Stress Chaperones, 2010
However, Hsp70 (HSPA1A) is present in the peripheral circulation of healthy nonpregnant and pregnant individuals.
Genetic risk for recurrent urinary tract infections in humans: a systematic review.
Review
Fanos et al., Verona, Italy. In J Biomed Biotechnol, 2009
In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels.
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Review
Carter, Hastings, United Kingdom. In Schizophr Bull, 2009
Other viral or bacterial components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by Apolipoprotein E (APOE).
Fertility testing and ICSI sperm selection by hyaluronic acid binding: clinical and genetic aspects.
Review
Ozkavukcu et al., New Haven, United States. In Reprod Biomed Online, 2007
The testis-expressed chaperone protein, HspA2 (previously creatine kinase M isoform) was established as a measure of human sperm cellular maturity, function and fertility.
Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance.
Impact
Saito et al., Kyoto, Japan. In Nat Biotechnol, 2001
Furthermore, this assay was found applicable for the detection of SNP existing in PCR amplification products of a 652-nucleotide sequence of the HSP70-2 gene.
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