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Tumor necrosis factor receptor superfamily, member 1A

HSP60, Shc, p55, Chaperonin 60, TNFR1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, PrP, HSP70
Papers using HSP60 antibodies
A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging
Supplier
Demignot Sylvie et al., In Biology of the Cell, 2008
... Rabbit polyclonal antibodies to LDH, prohibitin and HSP60 were obtained from Abcam.
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Supplier
Rocchi S et al., In Cell Death & Disease, 2008
... p21, p27, beclin1, HSP60 antibodies were purchased from Santa Cruz Biotechnology (TEBU; Le Perray en ...
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Supplier
Roh Gu Seob et al., In Anatomy & Cell Biology, 2008
... Antibodies against TNF-α, TNFR1 (H-5), TNFR2 (H-202), and lamin A (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2006
... Monoclonal anti-phospho-p42/p44 ERK1/2 antibody (610032) and polyclonal anti-Shc antibody (610082) were purchased from BD (BD Biosciences, Erembodegem, Belgium) ...
Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells.
Supplier
Schneider Guenter, In PLoS ONE, 2006
... Monoclonal anti-phospho-p42/p44 Erk1/2 and polyclonal anti-Shc were purchased from BD (BD Biosciences, Belgium) ...
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Papers on HSP60
Different EGF Receptor Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Protein.
New
Pike et al., Washington, D.C., United States. In J Biol Chem, Feb 2016
To determine the basis for these differences, we used luciferase fragment complementation imaging to monitor the recruitment of Cbl, CrkL, Gab1, Grb2, PI3K, p52 Shc, p66 Shc and Shp2 to the EGF receptor when stimulated by the seven EGF receptor ligands.
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.
New
Hörkkö et al., Oulu, Finland. In Immunol Res, Feb 2016
It is more intriguing that the binding molecule of Aa to Aa_Mab IgM was found to be Aa chaperonin 60 or HSP60, a member of heat-shock protein family, behaving not only as a chaperone for correct protein folding but also as a powerful virulence factor of the bacteria for inducing bone resorption and as a putative pathogenic factor in atherosclerosis.
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
New
Watanabe et al., In Digestion, Feb 2016
The upregulated MLCK expression was also observed in TNF-stimulated colonic epithelial cells in vitro in association with the upregulation of TNFR2 but not TNFR1/TNFRSF1a/p55.
Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease.
Review
New
Lüscher et al., Zürich, Switzerland. In Eur Heart J, Jan 2016
The mitochondrial adaptor protein p66(Shc) and the family of deacetylase enzymes, the sirtuins, regulate the aging process, determine lifespan of many species and are involved in CV diseases.
Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling.
New
Impact
Volterra et al., Lausanne, Switzerland. In Cell, Jan 2016
Here, we show that local increase of TNFα in the hippocampal dentate gyrus activates astrocyte TNF receptor type 1 (TNFR1), which in turn triggers an astrocyte-neuron signaling cascade that results in persistent functional modification of hippocampal excitatory synapses.
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
New
Impact
Dixit et al., San Francisco, United States. In Nature, Jan 2016
Mechanistically, linear ubiquitin chains preserve the architecture of the TNFR1 signalling complex by blocking A20-mediated disassembly of Lys63-linked polyubiquitin scaffolds.
Disturbances in apoptosis of lamina propria lymphocytes in Crohn's disease.
New
Linke et al., Poznań, Poland. In Arch Med Sci, Jan 2016
Each CD patient underwent colonoscopy with tissue sampling from inflamed areas of the colon with the assessment of immunohistochemical expression of active caspase 3, Fas, tumour necrosis factor receptor 1 (TNFR1), Bcl-2, Bax, CD4 and CD8.
S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer.
Review
New
Bettaieb et al., Dijon, France. In Redox Biol, Dec 2015
In the tumor microenvironment, stimulation of Fas, Death receptor 4 (DR4) and tumor necrosis factor receptor 1 (TNFR1) can initiate multiple signaling pathways driving either tumor promotion or elimination.
ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors.
New
Miaczynska et al., Warsaw, Poland. In Sci Signal, Dec 2015
These effects depended on cytokine receptors, such as the lymphotoxin β receptor (LTβR) and tumor necrosis factor receptor 1 (TNFR1).
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
New
Impact
Pasparakis et al., Köln, Germany. In Cancer Cell, Dec 2015
Knock-in expression of kinase inactive receptor-interacting protein kinase 1 (RIPK1) prevented hepatocyte apoptosis and HCC, while RIPK1 ablation induced TNFR1-associated death domain protein (TRADD)-dependent hepatocyte apoptosis and liver tumors in NEMO(LPC-KO) mice, revealing distinct kinase-dependent and scaffolding functions of RIPK1.
IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.
New
Impact
Pacifici et al., Atlanta, United States. In Cell Metab, Dec 2015
Mechanistically, cPTH stimulates conventional T cell production of TNFα (TNF), which increases the differentiation of IL-17A-producing Th17 cells via TNF receptor 1 (TNFR1) signaling in CD4(+) cells.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Review
New
Golemis et al., Philadelphia, United States. In Gene, Nov 2015
For these family members, additional mechanisms of action have been defined in receptor tyrosine kinase (RTK) signaling, estrogen receptor signaling or cell cycle progression, involving discrete partner proteins such as SHC, NSP proteins, or AURKA.
[Participation of heat shock proteins in modulation of NF-кB transcription factor activation during bacterial infections].
Review
Niemiałtowski et al., Warsaw, Poland. In Postepy Hig Med Dosw (online), 2014
Bacterial HSP, such as HSP60 of Chlamydia pneumophila and Helicobacter pylori, or GroL of Porphyromonas gingivalis, as well as HSP65 and HSP70 of Mycobacterium tuberculosis and DnaK of Francisella tularensis activate NF-κB and inflammation.
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
Impact
Pasparakis et al., Köln, Germany. In Nature, 2014
This pathology developed independently of the microbiota and of MyD88 signalling but was partly rescued by TNFR1 (also known as TNFRSF1A) deficiency.
[CHAPERONES FUNCTION HSP60 AND HSP90 AND THEIR ROLE IN CARDIAC PATHOLOGY].
Review
Silanteva et al., In Lik Sprava, 2014
In review provides information about the function oft the body of chaperones and their role in the development of pathological processes, including--atherosclerosis and coronary heart disease.
TNF-α influences the lateral dynamics of TNF receptor I in living cells.
GeneRIF
Heilemann et al., Würzburg, Germany. In Biochim Biophys Acta, 2012
Lateral dynamics of TNF-R1 before and after ligand binding, was investigated.
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
GeneRIF
LaFerla et al., Irvine, United States. In J Biol Chem, 2012
a novel interaction between APP and HSP60, which accounts for its translocation to the mitochondria.
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
GeneRIF
Stamenkovic et al., Lausanne, Switzerland. In Genes Dev, 2012
oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGF2BP2) regulates oxidative phosphorylation (OXPHOS) in primary glioblastoma (GBM) sphere cultures (gliomaspheres)
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
Impact
GeneRIF
Fugger et al., Oxford, United Kingdom. In Nature, 2012
analysis of multiple sclerosis GWAS data in conjunction with the 1000 Genomes Project data, shows genetic evidence that strongly implicates SNP rs1800693 as the causal variant in the TNFRSF1A region; further functional studies show that this MS risk allele directs expression of a novel, soluble form of TNFR1 that can block TNF
Increased immune reactivity towards human hsp60 in patients with primary Sjögren's syndrome is associated with increased cytokine levels and glandular inflammation.
GeneRIF
van Roon et al., In Clin Exp Rheumatol, 2012
Immune reactivity to human hsp60 contributes to immunopathology in primary Sjogren's syndrome.
More papers using HSP60 antibodies
Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells.
Supplier
Di Cunto Ferdinando, In PLoS ONE, 2004
... Primary antibodies used for immunocytochemistry were rabbit polyclonal Hsp60 from Abcam (Cambridge, USA); mouse monoclonal ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Supplier
Navarro Alfons, In PLoS ONE, 2003
... Anti-COX IV, anti-VDAC, anti-Hsp60, anti-SDHA, anti-AIF and anti-ND 6 antibodies were purchased from Abcam (Cambridge, MA, USA) ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Supplier
Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... anti-phospho-JAK1, anti-phospho-STAT1, STAT1, anti-phospho-IκBα and anti-SOCS3 (Cell Signalling, Danvers, MA, USA), anti-phospho-c-jun and anti-TNFα receptor (TNFR1) (Santa Cruz Biotechnology, Heidelberg, Germany, and anti-actin ...
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Supplier
Bate Michael, In PLoS Biology, 2002
... The antibodies against Trk (C-14), Cdk5 (DC-17), p35, and Shc were purchased from Santa Cruz Biotechnology ( ...
TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF-kappaB signaling pathways
Supplier
Mobasheri Ali et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... Monoclonal anti-ERK antibody and polyclonal anti-Shc antibody were purchased from Becton Dickinson (Heidelberg, Germany) ...
Cellular Prion Protein Promotes Brucella Infection into Macrophages
Supplier
Katamine Shigeru et al., In The Journal of Experimental Medicine, 2001
... Anti-Hsp60 rabbit polyclonal antibody was obtained from MBL International Corporation ...
Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the “cooperative end structures” model
Supplier
Cavallaro Ugo et al., In The Journal of Cell Biology, 2000
... anti-phospho–FRS-2α, rabbit anti–phospho-Src (recognizing the activated form of most Src kinases), rabbit anti-phospho–PLC-γ, anti–phospho-Shc, and anti-Shc (Cell Signaling Technology); rabbit anti-Erk1/2 and ...
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3
Supplier
Kholodenko Boris N et al., In Molecular Systems Biology, 2000
... (Beverly, MA), anti-phospho-Shc (Tyr317) and anti-Shc antibodies were purchased from Upstate Biotechnology (Lake Placid, NY), and all anti-ErbB receptor antibodies and anti-phosphotyrosine antibody (PY20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Regulation of the cell cycle by focal adhesion kinase
Supplier
Ossowski Liliana et al., In The Journal of Cell Biology, 1997
... 1/2 (anti-phospho-Tyr 204; clone E4), anti-NH2-Jun Kinase (JNK) (clone G7, phospho-Thr 183, and phospho-Tyr 185), anti-Shc (clone PG-797) were from Santa Cruz Biotechnology Inc ...
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
Supplier
Cheresh David et al., In The Journal of Cell Biology, 1994
... Mouse monoclonal Shc antibodies were from Santa Cruz Biotechnology.
Integrin transmembrane signaling and cytoskeletal control
Supplier
Yamada Kenneth M. et al., In The Journal of Cell Biology, 1994
... Monoclonal anti-H-Ras, anti-phospho-JNK and anti-Shc, as well as polyclonal anti-EGF receptor, anti-Grb2 and anti-Shc antibodies were purchased from Santa Cruz Biotechnology ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Supplier
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... p21 and TNFR1 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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