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Tumor necrosis factor receptor superfamily, member 1A

HSP60, Shc, p55, Chaperonin 60, TNFR1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, PrP, HSP70
Papers using HSP60 antibodies
A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging
Supplier
Demignot Sylvie et al., In Biology of the Cell, 2008
... Rabbit polyclonal antibodies to LDH, prohibitin and HSP60 were obtained from Abcam.
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Supplier
Rocchi S et al., In Cell Death & Disease, 2008
... p21, p27, beclin1, HSP60 antibodies were purchased from Santa Cruz Biotechnology (TEBU; Le Perray en ...
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Supplier
Roh Gu Seob et al., In Anatomy & Cell Biology, 2008
... Antibodies against TNF-α, TNFR1 (H-5), TNFR2 (H-202), and lamin A (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2006
... Monoclonal anti-phospho-p42/p44 ERK1/2 antibody (610032) and polyclonal anti-Shc antibody (610082) were purchased from BD (BD Biosciences, Erembodegem, Belgium) ...
Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells.
Supplier
Schneider Guenter, In PLoS ONE, 2006
... Monoclonal anti-phospho-p42/p44 Erk1/2 and polyclonal anti-Shc were purchased from BD (BD Biosciences, Belgium) ...
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Papers on HSP60
A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF Receptor Associated Periodic Syndrome (TRAPS).
New
Tighe et al., Nottingham, United Kingdom. In Eur J Immunol, 25 Apr 2014
UNLABELLED: Mutations in TNFRSF1A encoding TNF Receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder.
Urokinase Receptor (uPAR) Ligation Induces a Raft-Localized Integrin Signaling Switch that Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts.
New
Olman et al., Cleveland, United States. In J Biol Chem, 18 Apr 2014
The biological consequences of this translocation were an increase in fibroblast motility, and a switch of the integrin-initiated signal pathway for migration away from the lipid raft-independent focal adhesion kinase pathway, and towards a lipid raft-dependent caveolin-Fyn-Shc pathway.
The TNF family in T cell differentiation and function - Unanswered questions and future directions.
Review
New
Croft, Los Angeles, United States. In Semin Immunol, 05 Apr 2014
UNLABELLED: Proteins in the TNF/TNFR superfamily are recognized as major regulators of the activity of conventional CD4 and CD8 T cells, and also of regulatory T cells (Treg).
[Effect of shenxiong huayu capsule on cerebral ischemia/reperfusion injury and the expression of GAP43 in hippocampal CA1 of rats].
New
Zhao et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, 28 Feb 2014
OBJECTIVE: To explore the effect of Shenxiong Huayu Capsule (SHC) on the cerebral ischemia-reperfusion (IR) injury and the expression of growth associated protein 43 (GAP43) after total cerebral IR in the hippocampal CA1 region of rats.
Role of exosomes in myocardial remodeling.
Review
New
Ronquist et al., Umeå, Sweden. In Circ Res, 17 Feb 2014
Little is known and written about cardiac exosomes, although Gupta and Knowlton described exosomes containing HSP60 in 2007.
Involvement of IRS-1 Interaction with ADAM10 in the Regulation of Neurite Extension.
New
Amini et al., Philadelphia, United States. In J Cell Physiol, Jan 2014
The level of ADAM10 was found to be increased in immunohistochemical studies of HIV encephalitis clinical samples and is present with TNF-α and TNFR1 in both astrocytes and neurons.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
New
Impact
De Felice et al., Rio de Janeiro, Brazil. In Cell Metab, Jan 2014
Oligomers failed to trigger eIF2α-P and cognitive impairment in PKR(-/-) and TNFR1(-/-) mice.
Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants.
New
Goukassian et al., Tampa, United States. In Plos One, Dec 2013
Tumor necrosis factor-alpha (TNF) binds to two receptors: TNFR1/p55-cytotoxic and TNFR2/p75-pro-survival.
Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity.
New
Liu et al., Jinan, China. In Plos One, Dec 2013
Similar to TNFR1 and TNFR2, DR3 also directly bound to Atsttrin.
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.
New
Impact
Haase et al., Köln, Germany. In Immunity, Dec 2013
Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-κB was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of transcription 3 (STAT3) signaling in keratinocytes.
Chaperone machines for protein folding, unfolding and disaggregation.
Review
New
Impact
Saibil, London, United Kingdom. In Nat Rev Mol Cell Biol, Oct 2013
The structural basis of their mechanism of action is being unravelled (in particular for the heat shock proteins HSP60, HSP70, HSP90 and HSP100) and typically involves massive displacements of 20-30 kDa domains over distances of 20-50 Å and rotations of up to 100°.
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
New
Impact
Shao et al., Beijing, China. In Nature, Oct 2013
These cytokines are recognized by members of the TNF receptor (TNFR) family of death receptors, including TNFR1 and TNFR2, and FAS and TNF-related apoptosis-inducing ligand (TRAIL) receptors.
PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
New
Impact
Schneider et al., Paris, France. In Nat Med, Sep 2013
This dysregulation of TACE increases PrP(Sc) and Aβ accumulation and reduces shedding of TNF-α receptor type 1 (TNFR1).
Innate and Adaptive Responses to Heat Shock Proteins in Behcet's Disease.
Review
Direskeneli, İstanbul, Turkey. In Genet Res Int, 2012
60-kD HSP (HSP60) is also shown to be recognized by pattern recognition receptors such as toll-like receptors (TLR) and is suggested to be an endogenous "danger" signal to the immune system with rapid inflammatory cytokine releases and enhancement of adaptive Th1-type responses.
TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.
Review
Davis et al., Boston, United States. In Front Immunol, 2012
UNLABELLED: THE REGULATORY CYTOKINE TUMOR NECROSIS FACTOR (TNF) EXERTS ITS EFFECTS THROUGH TWO RECEPTORS: TNFR1 and TNFR2.
TNF-α influences the lateral dynamics of TNF receptor I in living cells.
GeneRIF
Heilemann et al., Würzburg, Germany. In Biochim Biophys Acta, 2012
Lateral dynamics of TNF-R1 before and after ligand binding, was investigated.
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
GeneRIF
LaFerla et al., Irvine, United States. In J Biol Chem, 2012
a novel interaction between APP and HSP60, which accounts for its translocation to the mitochondria.
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
GeneRIF
Stamenkovic et al., Lausanne, Switzerland. In Genes Dev, 2012
oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGF2BP2) regulates oxidative phosphorylation (OXPHOS) in primary glioblastoma (GBM) sphere cultures (gliomaspheres)
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
Impact
GeneRIF
Fugger et al., Oxford, United Kingdom. In Nature, 2012
analysis of multiple sclerosis GWAS data in conjunction with the 1000 Genomes Project data, shows genetic evidence that strongly implicates SNP rs1800693 as the causal variant in the TNFRSF1A region; further functional studies show that this MS risk allele directs expression of a novel, soluble form of TNFR1 that can block TNF
Increased immune reactivity towards human hsp60 in patients with primary Sjögren's syndrome is associated with increased cytokine levels and glandular inflammation.
GeneRIF
van Roon et al., In Clin Exp Rheumatol, 2012
Immune reactivity to human hsp60 contributes to immunopathology in primary Sjogren's syndrome.
More papers using HSP60 antibodies
Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells.
Supplier
Di Cunto Ferdinando, In PLoS ONE, 2004
... Primary antibodies used for immunocytochemistry were rabbit polyclonal Hsp60 from Abcam (Cambridge, USA); mouse monoclonal ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Supplier
Navarro Alfons, In PLoS ONE, 2003
... Anti-COX IV, anti-VDAC, anti-Hsp60, anti-SDHA, anti-AIF and anti-ND 6 antibodies were purchased from Abcam (Cambridge, MA, USA) ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Supplier
Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... anti-phospho-JAK1, anti-phospho-STAT1, STAT1, anti-phospho-IκBα and anti-SOCS3 (Cell Signalling, Danvers, MA, USA), anti-phospho-c-jun and anti-TNFα receptor (TNFR1) (Santa Cruz Biotechnology, Heidelberg, Germany, and anti-actin ...
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Supplier
Bate Michael, In PLoS Biology, 2002
... The antibodies against Trk (C-14), Cdk5 (DC-17), p35, and Shc were purchased from Santa Cruz Biotechnology ( ...
TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF-kappaB signaling pathways
Supplier
Mobasheri Ali et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... Monoclonal anti-ERK antibody and polyclonal anti-Shc antibody were purchased from Becton Dickinson (Heidelberg, Germany) ...
Cellular Prion Protein Promotes Brucella Infection into Macrophages
Supplier
Katamine Shigeru et al., In The Journal of Experimental Medicine, 2001
... Anti-Hsp60 rabbit polyclonal antibody was obtained from MBL International Corporation ...
Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the “cooperative end structures” model
Supplier
Cavallaro Ugo et al., In The Journal of Cell Biology, 2000
... anti-phospho–FRS-2α, rabbit anti–phospho-Src (recognizing the activated form of most Src kinases), rabbit anti-phospho–PLC-γ, anti–phospho-Shc, and anti-Shc (Cell Signaling Technology); rabbit anti-Erk1/2 and ...
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3
Supplier
Kholodenko Boris N et al., In Molecular Systems Biology, 2000
... (Beverly, MA), anti-phospho-Shc (Tyr317) and anti-Shc antibodies were purchased from Upstate Biotechnology (Lake Placid, NY), and all anti-ErbB receptor antibodies and anti-phosphotyrosine antibody (PY20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Regulation of the cell cycle by focal adhesion kinase
Supplier
Ossowski Liliana et al., In The Journal of Cell Biology, 1997
... 1/2 (anti-phospho-Tyr 204; clone E4), anti-NH2-Jun Kinase (JNK) (clone G7, phospho-Thr 183, and phospho-Tyr 185), anti-Shc (clone PG-797) were from Santa Cruz Biotechnology Inc ...
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
Supplier
Cheresh David et al., In The Journal of Cell Biology, 1994
... Mouse monoclonal Shc antibodies were from Santa Cruz Biotechnology.
Integrin transmembrane signaling and cytoskeletal control
Supplier
Yamada Kenneth M. et al., In The Journal of Cell Biology, 1994
... Monoclonal anti-H-Ras, anti-phospho-JNK and anti-Shc, as well as polyclonal anti-EGF receptor, anti-Grb2 and anti-Shc antibodies were purchased from Santa Cruz Biotechnology ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Supplier
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... p21 and TNFR1 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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