Role of oxidative stress in endothelial insulin resistance.
Stockholm, Sweden. In World J Diabetes, Apr 2015
Complex molecular circuits including endothelial nitric oxide synthase, prostacyclin synthase, mitochondrial adaptor p66(Shc), nicotinamide adenine dinucleotide phosphate-oxidase oxidase and nuclear factor kappa-B are discussed.
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
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Oxford, United Kingdom. In Nature, 2012
analysis of multiple sclerosis GWAS data in conjunction with the 1000 Genomes Project data, shows genetic evidence that strongly implicates SNP rs1800693 as the causal variant in the TNFRSF1A region; further functional studies show that this MS risk allele directs expression of a novel, soluble form of TNFR1 that can block TNF
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
In Journal of Neuroinflammation, 2003
... anti-phospho-JAK1, anti-phospho-STAT1, STAT1, anti-phospho-IκBα and anti-SOCS3 (Cell Signalling, Danvers, MA, USA), anti-phospho-c-jun and anti-TNFα receptor (TNFR1) (Santa Cruz Biotechnology, Heidelberg, Germany, and anti-actin ...