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Tumor necrosis factor receptor superfamily, member 1A

HSP60, Shc, p55, Chaperonin 60, TNFR1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, PrP, HSP70
Papers using HSP60 antibodies
A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging
Supplier
Demignot Sylvie et al., In Biology of the Cell, 2008
... Rabbit polyclonal antibodies to LDH, prohibitin and HSP60 were obtained from Abcam.
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Supplier
Rocchi S et al., In Cell Death & Disease, 2008
... p21, p27, beclin1, HSP60 antibodies were purchased from Santa Cruz Biotechnology (TEBU; Le Perray en ...
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Supplier
Roh Gu Seob et al., In Anatomy & Cell Biology, 2008
... Antibodies against TNF-α, TNFR1 (H-5), TNFR2 (H-202), and lamin A (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress
Supplier
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2006
... Monoclonal anti-phospho-p42/p44 ERK1/2 antibody (610032) and polyclonal anti-Shc antibody (610082) were purchased from BD (BD Biosciences, Erembodegem, Belgium) ...
Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells.
Supplier
Schneider Guenter, In PLoS ONE, 2006
... Monoclonal anti-phospho-p42/p44 Erk1/2 and polyclonal anti-Shc were purchased from BD (BD Biosciences, Belgium) ...
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Papers on HSP60
Electroacupuncture inhibits apoptosis of splenic lymphocytes in traumatized rats through modulation of the TNF-α/NF-κB signaling pathway.
New
Li et al., Harbin, China. In Mol Med Report, 22 Nov 2014
The apoptotic rate of the lymphocytes was measured by flow cytometric analysis, and western blotting was used to determine the protein expression levels of caspase‑3, caspase‑8, tumor necrosis factor (TNF)‑α and TNF receptor 1 (TNFR1).
Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways.
New
Lüscher et al., Zürich, Switzerland. In Eur Heart J, 21 Nov 2014
Here, we focused on the potential role of the adaptor protein p66(Shc) as a regulator of myocardial injury in a mouse model of cardiac ischaemia and reperfusion.
p16(INK4A) mediates age-related changes in mesenchymal stem cells derived from human dental pulp through the DNA damage and stress response.
New
Gu et al., Nantong, China. In Mech Ageing Dev, 07 Nov 2014
Meanwhile, the expression of p16(INK4A) and γ-H2A.X significantly increased with age, whereas heat shock protein 60 (HSP60) was decreased in the senescent DP-MSCs.
In-depth proteomic analysis of carp (Cyprinus carpio L) spermatozoa.
New
Ciereszko et al., Olsztyn, Poland. In Comp Biochem Physiol Part D Genomics Proteomics, 28 Oct 2014
Dynein, tubulin, HSP90, HSP70, HSP60, adenosylhomocysteinase, NKEF-B, brain type creatine kinase, mitochondrial ATP synthase, and valosin containing enzyme represent high abundance proteins in carp spermatozoa.
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
New
Impact
Pasparakis et al., Köln, Germany. In Nature, 04 Oct 2014
This pathology developed independently of the microbiota and of MyD88 signalling but was partly rescued by TNFR1 (also known as TNFRSF1A) deficiency.
Regulation of a TrkB Alternative Transcript by microRNAs.
New
Wong, Wollongong, Australia. In Dement Geriatr Cogn Dis Extra, 30 Sep 2014
In this study, the focus was placed on TrkB-Shc, a neuron-specific transcript, to determine if microRNAs (miRNAs) play a role in TrkB-Shc regulation.
Emerging role of protein kinase C in energy homeostasis: A brief overview.
Review
New
Mehta, Columbus, United States. In World J Diabetes, Jul 2014
Available data support the model in which PKCβ functions as a "diet-sensitive" metabolic sensor whose induction in adipose tissue by high-fat diet is among the initiating event disrupting mitochondrial homeostasis via intersecting with p66(Shc) signaling to amplify adipose dysfunction and have systemic consequences.
Activation of benign autoimmunity as both tumor and autoimmune disease immunotherapy: A comprehensive review.
Review
New
Cohen, Israel. In J Autoimmun, Jul 2014
With regard to the therapy of autoimmune diseases, I cite examples of immune system down-regulation of autoimmune diseases by T cell vaccination or HSP60 peptide treatment.
Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism.
Review
New
Cordonier et al., Lincoln, United States. In Nutr Rev, Jun 2014
Evidence is presented linking biotinylation of heat-shock proteins HSP60 and HSP72 with redox biology and immune function, respectively, and biotinylation of the two ENO1 gene products MBP-1 and ENO1 with tumor suppression and glycolysis, respectively.
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
New
Impact
Green et al., Memphis, United States. In Cell, Jun 2014
RIPK1 functions in vitro to limit caspase-8-dependent, TNFR-induced apoptosis, and animals lacking RIPK1, RIPK3, and TNFR1 survive to adulthood.
Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.
New
Impact
Liu et al., Tianjin, China. In Cancer Cell, Jun 2014
Aiolos also reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo.
Role of exosomes in myocardial remodeling.
Review
New
Ronquist et al., Umeå, Sweden. In Circ Res, Feb 2014
Little is known and written about cardiac exosomes, although Gupta and Knowlton described exosomes containing HSP60 in 2007.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
New
Impact
De Felice et al., Rio de Janeiro, Brazil. In Cell Metab, Jan 2014
Oligomers failed to trigger eIF2α-P and cognitive impairment in PKR(-/-) and TNFR1(-/-) mice.
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.
New
Impact
Haase et al., Köln, Germany. In Immunity, Dec 2013
Here we report that the development of psoriasis-like skin inflammation in mice with epidermis-specific inhibition of the transcription factor NF-κB was triggered by TNF receptor 1 (TNFR1)-dependent upregulation of interleukin-24 (IL-24) and activation of signal transducer and activator of transcription 3 (STAT3) signaling in keratinocytes.
Innate and Adaptive Responses to Heat Shock Proteins in Behcet's Disease.
Review
Direskeneli, İstanbul, Turkey. In Genet Res Int, 2012
60-kD HSP (HSP60) is also shown to be recognized by pattern recognition receptors such as toll-like receptors (TLR) and is suggested to be an endogenous "danger" signal to the immune system with rapid inflammatory cytokine releases and enhancement of adaptive Th1-type responses.
TNF-α influences the lateral dynamics of TNF receptor I in living cells.
GeneRIF
Heilemann et al., Würzburg, Germany. In Biochim Biophys Acta, 2012
Lateral dynamics of TNF-R1 before and after ligand binding, was investigated.
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
GeneRIF
LaFerla et al., Irvine, United States. In J Biol Chem, 2012
a novel interaction between APP and HSP60, which accounts for its translocation to the mitochondria.
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
GeneRIF
Stamenkovic et al., Lausanne, Switzerland. In Genes Dev, 2012
oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGF2BP2) regulates oxidative phosphorylation (OXPHOS) in primary glioblastoma (GBM) sphere cultures (gliomaspheres)
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
Impact
GeneRIF
Fugger et al., Oxford, United Kingdom. In Nature, 2012
analysis of multiple sclerosis GWAS data in conjunction with the 1000 Genomes Project data, shows genetic evidence that strongly implicates SNP rs1800693 as the causal variant in the TNFRSF1A region; further functional studies show that this MS risk allele directs expression of a novel, soluble form of TNFR1 that can block TNF
Increased immune reactivity towards human hsp60 in patients with primary Sjögren's syndrome is associated with increased cytokine levels and glandular inflammation.
GeneRIF
van Roon et al., In Clin Exp Rheumatol, 2012
Immune reactivity to human hsp60 contributes to immunopathology in primary Sjogren's syndrome.
More papers using HSP60 antibodies
Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells.
Supplier
Di Cunto Ferdinando, In PLoS ONE, 2004
... Primary antibodies used for immunocytochemistry were rabbit polyclonal Hsp60 from Abcam (Cambridge, USA); mouse monoclonal ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Supplier
Navarro Alfons, In PLoS ONE, 2003
... Anti-COX IV, anti-VDAC, anti-Hsp60, anti-SDHA, anti-AIF and anti-ND 6 antibodies were purchased from Abcam (Cambridge, MA, USA) ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Supplier
Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... anti-phospho-JAK1, anti-phospho-STAT1, STAT1, anti-phospho-IκBα and anti-SOCS3 (Cell Signalling, Danvers, MA, USA), anti-phospho-c-jun and anti-TNFα receptor (TNFR1) (Santa Cruz Biotechnology, Heidelberg, Germany, and anti-actin ...
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Supplier
Bate Michael, In PLoS Biology, 2002
... The antibodies against Trk (C-14), Cdk5 (DC-17), p35, and Shc were purchased from Santa Cruz Biotechnology ( ...
TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF-kappaB signaling pathways
Supplier
Mobasheri Ali et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... Monoclonal anti-ERK antibody and polyclonal anti-Shc antibody were purchased from Becton Dickinson (Heidelberg, Germany) ...
Cellular Prion Protein Promotes Brucella Infection into Macrophages
Supplier
Katamine Shigeru et al., In The Journal of Experimental Medicine, 2001
... Anti-Hsp60 rabbit polyclonal antibody was obtained from MBL International Corporation ...
Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the “cooperative end structures” model
Supplier
Cavallaro Ugo et al., In The Journal of Cell Biology, 2000
... anti-phospho–FRS-2α, rabbit anti–phospho-Src (recognizing the activated form of most Src kinases), rabbit anti-phospho–PLC-γ, anti–phospho-Shc, and anti-Shc (Cell Signaling Technology); rabbit anti-Erk1/2 and ...
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3
Supplier
Kholodenko Boris N et al., In Molecular Systems Biology, 2000
... (Beverly, MA), anti-phospho-Shc (Tyr317) and anti-Shc antibodies were purchased from Upstate Biotechnology (Lake Placid, NY), and all anti-ErbB receptor antibodies and anti-phosphotyrosine antibody (PY20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Regulation of the cell cycle by focal adhesion kinase
Supplier
Ossowski Liliana et al., In The Journal of Cell Biology, 1997
... 1/2 (anti-phospho-Tyr 204; clone E4), anti-NH2-Jun Kinase (JNK) (clone G7, phospho-Thr 183, and phospho-Tyr 185), anti-Shc (clone PG-797) were from Santa Cruz Biotechnology Inc ...
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
Supplier
Cheresh David et al., In The Journal of Cell Biology, 1994
... Mouse monoclonal Shc antibodies were from Santa Cruz Biotechnology.
Integrin transmembrane signaling and cytoskeletal control
Supplier
Yamada Kenneth M. et al., In The Journal of Cell Biology, 1994
... Monoclonal anti-H-Ras, anti-phospho-JNK and anti-Shc, as well as polyclonal anti-EGF receptor, anti-Grb2 and anti-Shc antibodies were purchased from Santa Cruz Biotechnology ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Supplier
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... p21 and TNFR1 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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