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Tumor necrosis factor receptor superfamily, member 1A

HSP60, Shc, p55, Chaperonin 60, TNFR1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, PrP, HSP70
Papers using HSP60 antibodies
A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging
Demignot Sylvie et al., In Biology of the Cell, 2008
... Rabbit polyclonal antibodies to LDH, prohibitin and HSP60 were obtained from Abcam.
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death
Rocchi S et al., In Cell Death & Disease, 2008
... p21, p27, beclin1, HSP60 antibodies were purchased from Santa Cruz Biotechnology (TEBU; Le Perray en ...
Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats
Roh Gu Seob et al., In Anatomy & Cell Biology, 2008
... Antibodies against TNF-α, TNFR1 (H-5), TNFR2 (H-202), and lamin A (C-20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress
Shakibaei Mehdi et al., In Arthritis Research & Therapy, 2006
... Monoclonal anti-phospho-p42/p44 ERK1/2 antibody (610032) and polyclonal anti-Shc antibody (610082) were purchased from BD (BD Biosciences, Erembodegem, Belgium) ...
Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells.
Schneider Guenter, In PLoS ONE, 2006
... Monoclonal anti-phospho-p42/p44 Erk1/2 and polyclonal anti-Shc were purchased from BD (BD Biosciences, Belgium) ...
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Papers on HSP60
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
Pasparakis et al., Köln, Germany. In Cancer Cell, 09 Dec 2015
Knock-in expression of kinase inactive receptor-interacting protein kinase 1 (RIPK1) prevented hepatocyte apoptosis and HCC, while RIPK1 ablation induced TNFR1-associated death domain protein (TRADD)-dependent hepatocyte apoptosis and liver tumors in NEMO(LPC-KO) mice, revealing distinct kinase-dependent and scaffolding functions of RIPK1.
Increased expressions of ADAMTS-13 and apoptosis contribute to neuropathology during Toxoplasma gondii encephalitis in mice.
Atmaca et al., Gümüşhane, Turkey. In Neuropathology, 06 Dec 2015
Mice were infected with ME49 strain T. gondii and the levels of ADAMTS-13, caspase 3, caspase 8, caspase 9, TNFR1 and Bcl-xL expressions were examined in brain tissues by immunohistochemistry, during the development and establishment of chronic infections at 10, 30 and 60 days post-infection.
Grating coupled SPR microarray analysis of proteins and cells in blood from mice with breast cancer.
Lawrence et al., Albany, United States. In Analyst, 05 Dec 2015
Furthermore, cytokines such as IL-6, IL-10 and TNF-α, along with heat shock proteins HSP60, HSP27, HSc70(HSP73), HSP90 total, HSP70/HSc70, HSP90, HSP70, HSP90 alpha, phosphotyrosine and HSF-1 were overexpressed in MMTV-PyVT mice.
TNF-α produced by SEC2 mutant (SAM-3)-activated human T cells induces apoptosis of HepG2 cells.
Zhang et al., Shenyang, China. In Appl Microbiol Biotechnol, 04 Dec 2015
Meanwhile, SAM-3 upregulated the expression of tumor necrosis factor receptor 1 (TNFR1) mRNA and activity of caspase-3 and caspase-8.
Molecular mechanism of endothelial and vascular aging: implications for cardiovascular disease.
Lüscher et al., Zürich, Switzerland. In Eur Heart J, 04 Dec 2015
The mitochondrial adaptor protein p66(Shc) and the family of deacetylase enzymes, the sirtuins, regulate the aging process, determine lifespan of many species and are involved in CV diseases.
IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.
Pacifici et al., Atlanta, United States. In Cell Metab, 03 Dec 2015
Mechanistically, cPTH stimulates conventional T cell production of TNFα (TNF), which increases the differentiation of IL-17A-producing Th17 cells via TNF receptor 1 (TNFR1) signaling in CD4(+) cells.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Golemis et al., Philadelphia, United States. In Gene, 01 Nov 2015
For these family members, additional mechanisms of action have been defined in receptor tyrosine kinase (RTK) signaling, estrogen receptor signaling or cell cycle progression, involving discrete partner proteins such as SHC, NSP proteins, or AURKA.
S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer.
Bettaieb et al., Dijon, France. In Redox Biol, 08 Oct 2015
In the tumor microenvironment, stimulation of Fas, Death receptor 4 (DR4) and tumor necrosis factor receptor 1 (TNFR1) can initiate multiple signaling pathways driving either tumor promotion or elimination.
TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects.
Probert, Athens, Greece. In Neuroscience, Sep 2015
TNF signaling comprises at minimum a two-ligand (soluble and transmembrane TNF) and two-receptor (TNFR1 and TNFR2) system, with ligands and receptors both differentially expressed and regulated on different cell types.
Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy.
Chen et al., Chicago, United States. In Nephron Extra, Jan 2015
TNF-α signaling of MCP-1 was elucidated by antibodies against TNF receptor (TNFR) 1 or TNFR2 or inhibitors of nuclear factor-kappaB (NF-κB), phosphatidylinositol 3-kinase (PI3K) or Akt.
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Lang et al., Düsseldorf, Germany. In Sci Signal, Dec 2014
Using a genetic screen, we found that the presence of either iRhom1 or iRhom2 lacking part of their extended amino-terminal cytoplasmic domain (herein referred to as ΔN) increases ADAM17 activity, TNFR shedding, and resistance to TNF-induced cell death in fibrosarcoma cells.
Heat shock protein HSP60 and the perspective for future using as vaccine antigens.
Stefaniak et al., Laizhou, China. In Postepy Hig Med Dosw (online), Dec 2014
HSPs have been classified in 10 families, one of them is the HSP60 family.
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis.
Pasparakis et al., Köln, Germany. In Nature, Oct 2014
This pathology developed independently of the microbiota and of MyD88 signalling but was partly rescued by TNFR1 (also known as TNFRSF1A) deficiency.
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Green et al., Memphis, United States. In Cell, Jun 2014
RIPK1 functions in vitro to limit caspase-8-dependent, TNFR-induced apoptosis, and animals lacking RIPK1, RIPK3, and TNFR1 survive to adulthood.
Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.
Liu et al., Tianjin, China. In Cancer Cell, Jun 2014
Aiolos also reconfigures chromatin structure within the SHC1 gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo.
TNF-α influences the lateral dynamics of TNF receptor I in living cells.
Heilemann et al., Würzburg, Germany. In Biochim Biophys Acta, 2012
Lateral dynamics of TNF-R1 before and after ligand binding, was investigated.
Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid.
LaFerla et al., Irvine, United States. In J Biol Chem, 2012
a novel interaction between APP and HSP60, which accounts for its translocation to the mitochondria.
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
Stamenkovic et al., Lausanne, Switzerland. In Genes Dev, 2012
oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGF2BP2) regulates oxidative phosphorylation (OXPHOS) in primary glioblastoma (GBM) sphere cultures (gliomaspheres)
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.
Fugger et al., Oxford, United Kingdom. In Nature, 2012
analysis of multiple sclerosis GWAS data in conjunction with the 1000 Genomes Project data, shows genetic evidence that strongly implicates SNP rs1800693 as the causal variant in the TNFRSF1A region; further functional studies show that this MS risk allele directs expression of a novel, soluble form of TNFR1 that can block TNF
Increased immune reactivity towards human hsp60 in patients with primary Sjögren's syndrome is associated with increased cytokine levels and glandular inflammation.
van Roon et al., In Clin Exp Rheumatol, 2012
Immune reactivity to human hsp60 contributes to immunopathology in primary Sjogren's syndrome.
More papers using HSP60 antibodies
Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells.
Di Cunto Ferdinando, In PLoS ONE, 2004
... Primary antibodies used for immunocytochemistry were rabbit polyclonal Hsp60 from Abcam (Cambridge, USA); mouse monoclonal ...
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Navarro Alfons, In PLoS ONE, 2003
... Anti-COX IV, anti-VDAC, anti-Hsp60, anti-SDHA, anti-AIF and anti-ND 6 antibodies were purchased from Abcam (Cambridge, MA, USA) ...
Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10–a role for IL-1 beta?
Lynch Marina A et al., In Journal of Neuroinflammation, 2003
... anti-phospho-JAK1, anti-phospho-STAT1, STAT1, anti-phospho-IκBα and anti-SOCS3 (Cell Signalling, Danvers, MA, USA), anti-phospho-c-jun and anti-TNFα receptor (TNFR1) (Santa Cruz Biotechnology, Heidelberg, Germany, and anti-actin ...
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Bate Michael, In PLoS Biology, 2002
... The antibodies against Trk (C-14), Cdk5 (DC-17), p35, and Shc were purchased from Santa Cruz Biotechnology ( ...
TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role of MEK1/2 and NF-kappaB signaling pathways
Mobasheri Ali et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... Monoclonal anti-ERK antibody and polyclonal anti-Shc antibody were purchased from Becton Dickinson (Heidelberg, Germany) ...
Cellular Prion Protein Promotes Brucella Infection into Macrophages
Katamine Shigeru et al., In The Journal of Experimental Medicine, 2001
... Anti-Hsp60 rabbit polyclonal antibody was obtained from MBL International Corporation ...
Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: evidence in support of the “cooperative end structures” model
Cavallaro Ugo et al., In The Journal of Cell Biology, 2000
... anti-phospho–FRS-2α, rabbit anti–phospho-Src (recognizing the activated form of most Src kinases), rabbit anti-phospho–PLC-γ, anti–phospho-Shc, and anti-Shc (Cell Signaling Technology); rabbit anti-Erk1/2 and ...
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3
Kholodenko Boris N et al., In Molecular Systems Biology, 2000
... (Beverly, MA), anti-phospho-Shc (Tyr317) and anti-Shc antibodies were purchased from Upstate Biotechnology (Lake Placid, NY), and all anti-ErbB receptor antibodies and anti-phosphotyrosine antibody (PY20) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Regulation of the cell cycle by focal adhesion kinase
Ossowski Liliana et al., In The Journal of Cell Biology, 1997
... 1/2 (anti-phospho-Tyr 204; clone E4), anti-NH2-Jun Kinase (JNK) (clone G7, phospho-Thr 183, and phospho-Tyr 185), anti-Shc (clone PG-797) were from Santa Cruz Biotechnology Inc ...
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
Cheresh David et al., In The Journal of Cell Biology, 1994
... Mouse monoclonal Shc antibodies were from Santa Cruz Biotechnology.
Integrin transmembrane signaling and cytoskeletal control
Yamada Kenneth M. et al., In The Journal of Cell Biology, 1994
... Monoclonal anti-H-Ras, anti-phospho-JNK and anti-Shc, as well as polyclonal anti-EGF receptor, anti-Grb2 and anti-Shc antibodies were purchased from Santa Cruz Biotechnology ...
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
Peppelenbosch M P et al., In Cell Death & Disease, 1991
... p21 and TNFR1 antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
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