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Serpin peptidase inhibitor, clade H

HSP47, gp46
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: CD45, Envelope Protein, Phosphogluconate Dehydrogenase, CAN, HAD
Papers on HSP47
Extracellular heat shock proteins protect U937 cells from H2O2-induced apoptotic cell death.
New
Pariente et al., Badajoz, Spain. In Mol Cell Biochem, Jan 2016
In the present study, we investigated the effect of extracellular exposure to four HSPs (HSP90, HSP70, HSP60, and HSP47) on apoptotic cell death induced by either oxidative stress (hydrogen peroxide) or endoplasmic reticulum stress-mediated intracellular calcium overload.
Thermal stress and the heat shock response in embryonic and young of the year juvenile lake whitefish.
New
Manzon et al., Regina, Canada. In Comp Biochem Physiol A Mol Integr Physiol, Jan 2016
By comparison, all three typically inducible hsps, hsp90α, hsp70 and hsp47, were upregulated in the YOY juveniles.
In vivo histological evaluation of fractional ablative microplasma radio frequency technology using a roller tip: an animal study.
New
Huang et al., Beijing, China. In Lasers Med Sci, Dec 2015
Heat shock protein (HSP) was also detected using immunohistochemistry.
Dermal fibroblast expression of stromal cell-derived factor-1 (SDF-1) promotes epidermal keratinocyte proliferation in normal and diseased skin.
New
Quan et al., Yanji, China. In Protein Cell, Dec 2015
Double immunostaining for SDF-1 and HSP47 (heat shock protein 47), a marker of fibroblasts, revealed that fibroblasts were the major source of stroma-cell-derived SDF-1 in both normal and diseased skin.
Effects of heat stress on respiratory burst, oxidative damage and SERPINH1 (HSP47) mRNA expression in rainbow trout Oncorhynchus mykiss.
New
Jiang et al., Lanzhou, China. In Fish Physiol Biochem, Dec 2015
In this study, spleen macrophage respiratory burst (RB), serum superoxide dismutase (SOD), serum malondialdehyde (MDA) and mRNA expression of the SERPINH1 (HSP47) gene in different tissues (liver, spleen, head kidney and heart) were measured in unstressed (18 °C) and heat-stressed (25 °C) fish.
Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice.
New
Fang et al., Chenzhou, China. In Mol Med Report, Oct 2015
It was found that after administration of ISO in Kunming and HSF1-/+ mice, there was a large number of fibers deposited around blood vessels and among cardiocytes, accompanied with an obvious increase in the protein expressions of type I or III collagen and heat shock protein 47 (HSP47), as indicated by western blot analysis.
Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain.
New
Nelson et al., Ames, United States. In J Biol Chem, Oct 2015
Rad50 and Mre11 form a complex involved in the detection and processing of DNA double strand breaks.
Osteogenesis imperfecta due to mutations in non-collagenous genes: lessons in the biology of bone formation.
Review
Smith et al., Bethesda, United States. In Curr Opin Pediatr, 2014
Heat shock protein 47 (HSP47) and FK506-binding protein-65 (FKBP65) defects cause types X and XI osteogenesis imperfecta via aberrant collagen crosslinking, folding, and chaperoning, while defects in SP7 transcription factor, wingless-type MMTV integration site family member 1 (WNT1), trimeric intracellular cation channel type b (TRIC-B), and old astrocyte specifically induced substance (OASIS) disrupt osteoblast development.
Bone collagen: new clues to its mineralization mechanism from recessive osteogenesis imperfecta.
Review
Weis et al., Seattle, United States. In Calcif Tissue Int, 2013
They include CRTAP, LEPRE1, and PPIB, which encode three proteins forming the prolyl 3-hydroxylase complex; PLOD2 and FKBP10, which encode, respectively, lysyl hydroxylase 2 and a foldase required for its activity in forming mature cross-links in bone collagen; SERPINH1, which encodes the collagen chaperone HSP47; SERPINF1, which encodes pigment epithelium-derived factor required for osteoid mineralization; and BMP1, which encodes the type I procollagen C-propeptidase.
New genes in bone development: what's new in osteogenesis imperfecta.
Review
Blissett et al., Bethesda, United States. In J Clin Endocrinol Metab, 2013
Next, defects in collagen chaperones, HSP47 and FKBP65, lead to improper procollagen folding and deficient collagen cross-linking in matrix, respectively.
HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways.
GeneRIF
Sun et al., Changsha, China. In Am J Physiol Renal Physiol, 2012
HSP47 specifically modulates TGF-beta1-induced extracellular matrix protein synthesis in HK-2 cells
The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation.
GeneRIF
Nagata et al., Kyoto, Japan. In J Cell Sci, 2012
These results demonstrate that Hsp47 is indispensable for well-organized cartilage and normal endochondral bone formation.
Direct in vitro and in vivo evidence for interaction between Hsp47 protein and collagen triple helix.
GeneRIF
Nagata et al., Yokohama, Japan. In J Biol Chem, 2012
Hsp47 recognizes the triple-helix form of procollagen in vitro and in vivo.
[Mutations of noncollagen genes in osteogenesis imperfecta--implications of the gene products in collagen biosynthesis and pathogenesis of disease].
Review
Galicka, In Postepy Hig Med Dosw (online), 2011
The latest findings added to the spectrum of OI-causing and collagen-influencing factors other chaperones (HSP47 and FKBP65) and protein BMP-1, which emphasizes the complexity of collagen folding and secretion as well as their importance in bone formation.
Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction.
GeneRIF
Noguchi et al., Ōita, Japan. In Thorac Cardiovasc Surg, 2011
Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction.
The prevalence and significance of HTLV-I/II seroindeterminate Western blot patterns.
Review
Jacobson et al., Bethesda, United States. In Viruses, 2011
HTLV-I seropositive results are defined by the presence of antibodies against either gp46 or gp62/68 (both Env protein bands) and either p19, p24, or p53 (one of the gag bands).
Effect of heat shock protein 47 on collagen synthesis of keloid in vivo.
GeneRIF
Wang et al., China. In Anz J Surg, 2011
overexpression of HSP47 in keloid fibroblast cells could induce excessive collagen accumulation by enhancing collagen synthesis, which not only presents a possible mechanism of keloid formation
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone.
Impact
Niitsu et al., Sapporo, Japan. In Nat Biotechnol, 2008
We used vitamin A-coupled liposomes to deliver small interfering RNA (siRNA) against gp46, the rat homolog of human heat shock protein 47, to hepatic stellate cells.
Antibody profile of early HTLV-I infection.
Impact
Essex et al., Boston, United States. In Lancet, 1990
The confirmatory tests identified 8 seroconverters (7 women, 1 man); their serum samples were used to study the antibody reactivity by western blot assays to HTLV-I specific antigens (three recombinant proteins spanning the N-terminal, middle, and C-terminal env glycoprotein gp46; a recombinant transmembrane protein gp21; a recombinant tax protein; and three gag proteins [p28, p24, and p19]).
Type-specific antigens for serological discrimination of HTLV-I and HTLV-II infection.
Impact
Essex et al., Boston, United States. In Lancet, 1990
Recombinant protein (RP) B1 contains aminoacids 166-201 from HTLV-I exterior glycoprotein gp46 and was reactive with HTLV-I samples only.
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