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Heat shock 27kDa protein 1

HSP27, HSP25
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HSP70, p38, CAN, V1a, MAPK
Papers using HSP27 antibodies
The structure of native G-actin
Supplier
Graceffa Philip, In Biochemistry Research International, 2009
... Full-length Hsp27 was prepared by bacterial expression and purification using the New England Biolabs IMPACT-CN intein system, as ...
Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise.
Supplier
Saks Valdur, In PLoS ONE, 2008
... Rabbit polyclonal anti-phospho-Hsp27 (Ser 15) antibody, rabbit polyclonal anti-Hsp27 antibody and horseradish peroxidase–conjugated secondary goat anti-rabbit IgG were purchased from Santa Cruz (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Regulation of p21Waf1 expression and TNFa biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
Supplier
Moens Ugo et al., In Journal of Molecular Signaling, 2006
... PhosphoSer-15 Hsp27 antibody was from Cell Signaling technology (cat ...
Polyethylenimine, a cost-effective transfection reagent.
Supplier
Kampinga Harm, In PLoS ONE, 2005
... ERK2 (sc-1647) and Hsp27 (sc-1048) antibodies were from Santa Cruz Biotechnology, Other antibodies used were ...
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
Supplier
Costanzo Vincenzo et al., In The EMBO Journal, 2005
... The antibodies used were anti-human G6PD goat polyclonal (Abcam), anti-Hsp27 mouse monoclonal (Santa Cruz Biotechnology) for immunoprecipitation, anti-Hsp27 rabbit ...
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Papers on HSP27
Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells.
New
Zheng et al., Hangzhou, China. In Mol Med Report, 31 May 2014
Adenovirus (~2.5x1012 viral particles) bearing the human heat shock protein 27 (HSP27) gene was injected into rat liver through the ileocecal vein.
OVA66 Increases Cell Growth, Invasion, and Survival via Regulation of IGF-1R-MAPK Signaling in Human Cancer Cells.
New
Ge et al., Shanghai, China. In Carcinogenesis, 25 Apr 2014
Stable knockdown of OVA66 in cancer cells attenuated phosphorylation of IGF-1R and ERK1/2-Hsp27; similarly, a higher level of p-IGF-1R and ERK1/2-Hsp27 signaling were also detected after OVA66 overexpression in HO8910 cells.
Anti-ribosomal-P antibodies accelerate lupus glomerulonephritis and induce lupus nephritis in naïve mice.
New
Shoenfeld et al., Tel Aviv-Yafo, Israel. In J Autoimmun, 21 Apr 2014
Primary mesangial cells exposed to mouse anti-Ribos.P mAb originated from the immunized lupus mice and to human anti-Ribos.P Abs, induced activation of mesangial cells via p38α, JNK, AKT and HSP27 MAPKs expression pathway.
miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma.
New
Yun et al., Guangzhou, China. In Oncogene, 17 Apr 2014
Interference of the PTEN/HSP27 pathway contributed to miR-625-mediated metastasis inhibition.
Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins.
New
Pichika et al., Kuala Lumpur, Malaysia. In Eur J Med Chem, 03 Apr 2014
The results showed that 20 apoptotic markers (Bad, Bax, Bcl-2, Bcl-w, Bid, Bim, CD40, Fas, HSP27, IGF-1, IGFBP-4, IGFBP-5, Livin, p21, Survivin, sTNF-R2, TRAIL-R2, XIAP, caspase-3 and caspase-8) were either up regulated or down regulated.
Transient hypoxia leads to increased serum levels of heat shock protein-27, -70 and caspase-cleaved cytokeratin 18.
New
Jung et al., In Clin Lab, Dec 2013
We have previously shown that elevated levels of heat shock protein-27 (HSP27), -70 (HSP70), and caspase-cleaved cytokeratin 18 (ccCK-18) were found in serum of COPD patients correlating with disease severity.
Melatonin influences pancreatic cancerogenesis.
Review
New
Leja-Szpak et al., Kraków, Poland. In Histol Histopathol, Dec 2013
On the contrary, low concentrations of melatonin turn on the production of anti-apoptotic heat shock proteins: HSP27, HSP70, and HSP90, which prevents the activation of caspase-3.
The role of heat shock proteins in bladder cancer.
Review
New
So et al., Vancouver, Canada. In Nat Rev Urol, Jul 2013
A combination of OGX-427 (an antisense oligonucleotide that targets HSP27), gemcitabine, and cisplatin is currently being investigated in a phase II trial of patients with advanced bladder cancer.
Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function.
Review
New
Arrigo et al., Lyon, France. In Philos Trans R Soc Lond B Biol Sci, Jun 2013
Human HSP27 (HSPB1) is a molecular chaperone sensor which, through dynamic changes in its phosphorylation and oligomerization, allows cells to adapt to changes in their physiology and/or mount a protective response to injuries.
Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets.
Review
New
McAlpine et al., Sydney, Australia. In Bioorg Med Chem Lett, May 2013
Examples of efficacious strategies include the inhibition of hsp27, which prevents protein aggregation, controlling hsp40's role as an ATPase modulator, and inhibiting hsp70 from acting as a molecular chaperone.
HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.
GeneRIF
Liao et al., Changsha, China. In Int J Radiat Oncol Biol Phys, 2012
results demonstrate significant associations between overall survival and SNPs in HSPB1 rs2868371 in USA patients with NSCLC after radio(chemo)therapy.
[Safty action of heat shock protein 27 in reperfusion after spinal marrow ischemia].
Review
Lin et al., Putian, China. In Zhongguo Gu Shang, 2012
Heat shock protein 27 belongs to the heat shock protein family in the small molecular weight family.
The protective roles of phosphorylated heat shock protein 27 in human cells harboring myoclonus epilepsy with ragged-red fibers A8344G mtDNA mutation.
GeneRIF
Hsieh et al., China. In Febs J, 2012
our results demonstrate that p-HSP27 provides significant protection when cells are exposed to different stresses in the cell model of MERRF syndrome
Increased expression of heat shock protein 27 correlates with peritoneal metastasis in epithelial ovarian cancer.
GeneRIF
Chen et al., Wuxi, China. In Reprod Sci, 2012
Data suggest that higher levels of HSP27 in tumor tissue from patients with epithelial ovarian cancer are associated with peritoneal metastasis; thus, tumor HSP27 level may be useful prognostic marker of poor survival.
p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression.
GeneRIF
Sakurai et al., Ōsaka, Japan. In Free Radic Biol Med, 2012
p38MAPK suppresses chronic pancreatitis by upregulating HSP27 expression and downregulating BAD expression.
A novel p.Glu175X premature stop mutation in the C-terminal end of HSP27 is a cause of CMT2.
GeneRIF
Reilly et al., London, United Kingdom. In J Peripher Nerv Syst, 2012
we present a family with a novel mutation in the C-terminus of HSP27 (p.Glu175X) with a motor predominant distal neuropathy but with definite sensory involvement compatible with axonal Charcot-Marie-Tooth disease
Large potentials of small heat shock proteins.
Review
Impact
Gusev et al., Moscow, Russia. In Physiol Rev, 2011
Ubiquitously expressed HSPB1 (HSP27) is involved in the control of protein folding and, when mutated, plays a significant role in the development of certain neurodegenerative disorders.
High-mobility group box 1 is essential for mitochondrial quality control.
Impact
Lotze et al., Pittsburgh, United States. In Cell Metab, 2011
We show that heat shock protein beta-1 (HSPB1 or HSP27) is the downstream mediator of this effect.
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Impact
GeneRIF
Timmerman et al., New York City, United States. In Nat Genet, 2004
missense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) that segregates in a family with Charcot-Marie-Tooth disease
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
Impact
Saklatvala et al., Cambridge, United Kingdom. In Cell, 1994
An IL-1-stimulated protein kinase cascade resulting in phosphorylation of the small heat shock protein hsp27 has been identified in KB cells.
More papers using HSP27 antibodies
The PANTHER database of protein families, subfamilies, functions and pathways
Supplier
Weiss Robert H et al., In Molecular Cancer, 2004
... Goat polyclonal Hsp-27 and rabbit polyclonal phospho-Hsp27 antibodies were obtained from Santa Cruz Biotechnology and used at a 1:1000 ...
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
Supplier
Sugden Peter H. et al., In The Journal of Cell Biology, 1994
... The antibody to HSP25/27 (sc-1049) was from Santa Cruz Biotechnology Inc. ...
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