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Heat shock 27kDa protein 1

HSP27, HSP25
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, p38, V1a, HAD
Papers using HSP27 antibodies
The structure of native G-actin
Supplier
Graceffa Philip, In Biochemistry Research International, 2009
... Full-length Hsp27 was prepared by bacterial expression and purification using the New England Biolabs IMPACT-CN intein system, as ...
Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise.
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Saks Valdur, In PLoS ONE, 2008
... Rabbit polyclonal anti-phospho-Hsp27 (Ser 15) antibody, rabbit polyclonal anti-Hsp27 antibody and horseradish peroxidase–conjugated secondary goat anti-rabbit IgG were purchased from Santa Cruz (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Regulation of p21Waf1 expression and TNFa biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
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Moens Ugo et al., In Journal of Molecular Signaling, 2006
... PhosphoSer-15 Hsp27 antibody was from Cell Signaling technology (cat ...
Polyethylenimine, a cost-effective transfection reagent.
Supplier
Kampinga Harm, In PLoS ONE, 2005
... ERK2 (sc-1647) and Hsp27 (sc-1048) antibodies were from Santa Cruz Biotechnology, Other antibodies used were ...
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
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Costanzo Vincenzo et al., In The EMBO Journal, 2005
... The antibodies used were anti-human G6PD goat polyclonal (Abcam), anti-Hsp27 mouse monoclonal (Santa Cruz Biotechnology) for immunoprecipitation, anti-Hsp27 rabbit ...
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Papers on HSP27
HEK293 cells exposed to microcystin-LR show reduced protein phosphatase 2A activity and more stable cytoskeletal structure when overexpressing α4 protein.
New
Xu et al., Hangzhou, China. In Environ Toxicol, Feb 2016
However, the assembly of actin filament and microtubules remained unchanged and the expression and phosphorylation of the cytoskeleton-related proteins HSP27 and VASP did not increase significantly.
Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas.
New
Svasti et al., Bangkok, Thailand. In Oncol Rep, Feb 2016
Eight biomarkers could distinguish PTC from normal tissues, namely enolase 1, triose phosphate isomerase, cathepsin D, annexin A2, cofilin 1, proliferating cell nuclear antigen (PCNA), copine 1 and heat shock protein 27 kDa (HSP27).
Weight loss-induced stress in subcutaneous adipose tissue is related to weight regain.
New
Mariman et al., Maastricht, Netherlands. In Br J Nutr, Feb 2016
WR showed increased expressions of β-actin, calnexin, heat shock protein (HSP) 27, HSP60 and HSP70.
Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism.
New
Kaman et al., Elazığ, Turkey. In Blood Coagul Fibrinolysis, Feb 2016
UNASSIGNED: We determined the levels of some heat shock proteins (HSP27, HSP70, and HSP90), L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) levels in patients with acute pulmonary embolism.
Human cytomegalovirus stimulates the synthesis of select Akt-dependent antiapoptotic proteins during viral entry to promote survival of infected monocytes.
New
Chan et al., Chapel Hill, United States. In J Virol, Feb 2016
Mechanistically, HCMV upregulated two specific cellular antiapoptotic proteins, myeloid leukemia sequence 1 (Mcl-1) and heat shock protein 27 (HSP27), to block the two proteolytic cleavages necessary for the formation of fully active caspase 3 and the subsequent initiation of apoptosis.
Multifaceted roles of HSF1 in cancer.
Review
New
Zhao et al., Chengdu, China. In Tumour Biol, Jul 2015
First, HSF1 regulates the expression of heat shock proteins (HSPs) including HSP90, HSP70, and HSP27.
The role of heat shock proteins in cancer.
Review
New
Roukos et al., Ioánnina, Greece. In Cancer Lett, Jun 2015
According to their size they have been classified into the following families; HSP90, HSP70, HSP60, HSP40 and HSP27.
Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse.
Marzban et al., Winnipeg, Canada. In Int J Mol Sci, 2014
Despite massive Pc degeneration that was observed in the nax mouse cerebellum, p75NTR pattern expression was similar to the HSP25 pattern in nax mice and comparable with wild type sibling cerebellum.
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review).
Review
Zhang et al., Nanjing, China. In Int J Oncol, 2014
Among the heat shock proteins (HSP), HSP27, HSP70 and HSP90 are the most studied stress-inducible HSPs, and are induced in response to a wide variety of physiological and environmental insults, thus allowing cells to survive to lethal conditions based on their powerful cytoprotective functions.
Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells: possible involvement of stress proteins and gene expression.
Review
Croute et al., Toulouse, France. In Neural Regen Res, 2014
Besides, western blot analysis of stress proteins (HSP27, HSP70, GRP78 and GRP94) showed an over-expression of two proteins: a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27.
Melatonin influences pancreatic cancerogenesis.
Review
Leja-Szpak et al., Kraków, Poland. In Histol Histopathol, 2014
On the contrary, low concentrations of melatonin turn on the production of anti-apoptotic heat shock proteins: HSP27, HSP70, and HSP90, which prevents the activation of caspase-3.
HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.
GeneRIF
Liao et al., Changsha, China. In Int J Radiat Oncol Biol Phys, 2012
results demonstrate significant associations between overall survival and SNPs in HSPB1 rs2868371 in USA patients with NSCLC after radio(chemo)therapy.
The protective roles of phosphorylated heat shock protein 27 in human cells harboring myoclonus epilepsy with ragged-red fibers A8344G mtDNA mutation.
GeneRIF
Hsieh et al., Taiwan. In Febs J, 2012
our results demonstrate that p-HSP27 provides significant protection when cells are exposed to different stresses in the cell model of MERRF syndrome
Increased expression of heat shock protein 27 correlates with peritoneal metastasis in epithelial ovarian cancer.
GeneRIF
Chen et al., Wuxi, China. In Reprod Sci, 2012
Data suggest that higher levels of HSP27 in tumor tissue from patients with epithelial ovarian cancer are associated with peritoneal metastasis; thus, tumor HSP27 level may be useful prognostic marker of poor survival.
p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression.
GeneRIF
Sakurai et al., Ōsaka, Japan. In Free Radic Biol Med, 2012
p38MAPK suppresses chronic pancreatitis by upregulating HSP27 expression and downregulating BAD expression.
A novel p.Gln175X [corrected] premature stop mutation in the C-terminal end of HSP27 is a cause of CMT2.
GeneRIF
Reilly et al., London, United Kingdom. In J Peripher Nerv Syst, 2012
we present a family with a novel mutation in the C-terminus of HSP27 (p.Glu175X) with a motor predominant distal neuropathy but with definite sensory involvement compatible with axonal Charcot-Marie-Tooth disease
Large potentials of small heat shock proteins.
Review
Impact
Gusev et al., Moscow, Russia. In Physiol Rev, 2011
Ubiquitously expressed HSPB1 (HSP27) is involved in the control of protein folding and, when mutated, plays a significant role in the development of certain neurodegenerative disorders.
High-mobility group box 1 is essential for mitochondrial quality control.
Impact
Lotze et al., Pittsburgh, United States. In Cell Metab, 2011
We show that heat shock protein beta-1 (HSPB1 or HSP27) is the downstream mediator of this effect.
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Impact
GeneRIF
Timmerman et al., New York City, United States. In Nat Genet, 2004
missense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) that segregates in a family with Charcot-Marie-Tooth disease
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
Impact
Saklatvala et al., Cambridge, United Kingdom. In Cell, 1994
An IL-1-stimulated protein kinase cascade resulting in phosphorylation of the small heat shock protein hsp27 has been identified in KB cells.
More papers using HSP27 antibodies
The PANTHER database of protein families, subfamilies, functions and pathways
Supplier
Weiss Robert H et al., In Molecular Cancer, 2004
... Goat polyclonal Hsp-27 and rabbit polyclonal phospho-Hsp27 antibodies were obtained from Santa Cruz Biotechnology and used at a 1:1000 ...
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
Supplier
Sugden Peter H. et al., In The Journal of Cell Biology, 1994
... The antibody to HSP25/27 (sc-1049) was from Santa Cruz Biotechnology Inc. ...
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