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Heat shock 27kDa protein 1

HSP27, HSP25
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: HSP70, CAN, p38, V1a, HAD
Papers using HSP27 antibodies
The structure of native G-actin
Supplier
Graceffa Philip, In Biochemistry Research International, 2009
... Full-length Hsp27 was prepared by bacterial expression and purification using the New England Biolabs IMPACT-CN intein system, as ...
Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise.
Supplier
Saks Valdur, In PLoS ONE, 2008
... Rabbit polyclonal anti-phospho-Hsp27 (Ser 15) antibody, rabbit polyclonal anti-Hsp27 antibody and horseradish peroxidase–conjugated secondary goat anti-rabbit IgG were purchased from Santa Cruz (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Regulation of p21Waf1 expression and TNFa biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
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Moens Ugo et al., In Journal of Molecular Signaling, 2006
... PhosphoSer-15 Hsp27 antibody was from Cell Signaling technology (cat ...
Polyethylenimine, a cost-effective transfection reagent.
Supplier
Kampinga Harm, In PLoS ONE, 2005
... ERK2 (sc-1647) and Hsp27 (sc-1048) antibodies were from Santa Cruz Biotechnology, Other antibodies used were ...
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
Supplier
Costanzo Vincenzo et al., In The EMBO Journal, 2005
... The antibodies used were anti-human G6PD goat polyclonal (Abcam), anti-Hsp27 mouse monoclonal (Santa Cruz Biotechnology) for immunoprecipitation, anti-Hsp27 rabbit ...
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Papers on HSP27
Ischemic postconditioning prevents renal ischemia reperfusion injury through the induction of heat shock proteins in rats.
New
Wang et al., Shijiazhuang, China. In Mol Med Report, 31 Dec 2014
This study tested the hypothesis that IPo attenuates renal IRI through the upregulation of heat shock protein (HSP)70, HSP27 and heme oxygenase‑1 (HO‑1, also known as HSP 32) expression.
HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat-shock.
New
Claire et al., Grenoble, France. In Mol Biol Cell, 08 Nov 2014
UNLABELLED: After heat-shock, HSF1 controls a major cellular transcriptional response involving the activation of early (Hsp70) and late (Hsp25) heat shock gene expression.
Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training.
New
Paulsen et al., Oslo, Norway. In Physiol Rep, 01 Nov 2014
Eleven weeks of endurance training decreased muscle GPx1, HSP27 and αB-crystallin, while mnSOD, HSP70 and GSH remained unchanged, with no influence of supplementation.
Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
New
Shen et al., Shanghai, China. In Eur J Med Chem, 22 Oct 2014
Compound 108 exhibited its functional inhibition of HSP90 by depleting key signaling pathways and concomitantly elevating of HSP70 and HSP27 in U-87MG cells.
Chronic neuroprotective effects of low concentration lithium on SH-SY5Y cells: possible involvement of stress proteins and gene expression.
Review
New
Croute et al., Toulouse, France. In Neural Regen Res, May 2014
Besides, western blot analysis of stress proteins (HSP27, HSP70, GRP78 and GRP94) showed an over-expression of two proteins: a 105 kDa protein which is a hyper-phosphorylated isoform of GRP94, and a 108 kDa protein which is a phosphorylated tetramer of HSP27.
Atrazine Affects Phosphoprotein and Protein Expression in MCF-10A Human Breast Epithelial Cells.
New
Song et al., Jefferson City, United States. In Int J Mol Sci, Dec 2013
MALDI-TOF MS/MS analysis revealed that the differentially expressed proteins belong to various cellular compartments (nucleus, cytosol, membrane) and varied in function, including those regulating the stress response such as peroxiredoxin I, HSP70 and HSP27; structural proteins such as tropomyosin and profilin 1; and oncogenesis proteins such as ANP32A.
Expression of heat shock proteins in brain tumors.
New
Vartholomatos et al., Ioánnina, Greece. In Turk Neurosurg, Dec 2013
MATERIAL AND METHODS: Simultaneous detection of HSP27, HSP40, HSP60, HSP70, HSP90a, total Akt and phospho- Akt in 19 brain tumor specimens was performed using the multiplex bead array assay.
The role of heat shock proteins in bladder cancer.
Review
New
So et al., Vancouver, Canada. In Nat Rev Urol, Jul 2013
A combination of OGX-427 (an antisense oligonucleotide that targets HSP27), gemcitabine, and cisplatin is currently being investigated in a phase II trial of patients with advanced bladder cancer.
Peptide aptamers: tools to negatively or positively modulate HSPB1(27) function.
Review
New
Arrigo et al., Lyon, France. In Philos Trans R Soc Lond B Biol Sci, Jun 2013
Human HSP27 (HSPB1) is a molecular chaperone sensor which, through dynamic changes in its phosphorylation and oligomerization, allows cells to adapt to changes in their physiology and/or mount a protective response to injuries.
Heat shock proteins 27, 40, and 70 as combinational and dual therapeutic cancer targets.
Review
New
McAlpine et al., Sydney, Australia. In Bioorg Med Chem Lett, May 2013
Examples of efficacious strategies include the inhibition of hsp27, which prevents protein aggregation, controlling hsp40's role as an ATPase modulator, and inhibiting hsp70 from acting as a molecular chaperone.
HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.
GeneRIF
Liao et al., Changsha, China. In Int J Radiat Oncol Biol Phys, 2012
results demonstrate significant associations between overall survival and SNPs in HSPB1 rs2868371 in USA patients with NSCLC after radio(chemo)therapy.
[Safty action of heat shock protein 27 in reperfusion after spinal marrow ischemia].
Review
Lin et al., Putian, China. In Zhongguo Gu Shang, 2012
Heat shock protein 27 belongs to the heat shock protein family in the small molecular weight family.
The protective roles of phosphorylated heat shock protein 27 in human cells harboring myoclonus epilepsy with ragged-red fibers A8344G mtDNA mutation.
GeneRIF
Hsieh et al., China. In Febs J, 2012
our results demonstrate that p-HSP27 provides significant protection when cells are exposed to different stresses in the cell model of MERRF syndrome
Increased expression of heat shock protein 27 correlates with peritoneal metastasis in epithelial ovarian cancer.
GeneRIF
Chen et al., Wuxi, China. In Reprod Sci, 2012
Data suggest that higher levels of HSP27 in tumor tissue from patients with epithelial ovarian cancer are associated with peritoneal metastasis; thus, tumor HSP27 level may be useful prognostic marker of poor survival.
p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression.
GeneRIF
Sakurai et al., Ōsaka, Japan. In Free Radic Biol Med, 2012
p38MAPK suppresses chronic pancreatitis by upregulating HSP27 expression and downregulating BAD expression.
A novel p.Glu175X premature stop mutation in the C-terminal end of HSP27 is a cause of CMT2.
GeneRIF
Reilly et al., London, United Kingdom. In J Peripher Nerv Syst, 2012
we present a family with a novel mutation in the C-terminus of HSP27 (p.Glu175X) with a motor predominant distal neuropathy but with definite sensory involvement compatible with axonal Charcot-Marie-Tooth disease
Large potentials of small heat shock proteins.
Review
Impact
Gusev et al., Moscow, Russia. In Physiol Rev, 2011
Ubiquitously expressed HSPB1 (HSP27) is involved in the control of protein folding and, when mutated, plays a significant role in the development of certain neurodegenerative disorders.
High-mobility group box 1 is essential for mitochondrial quality control.
Impact
Lotze et al., Pittsburgh, United States. In Cell Metab, 2011
We show that heat shock protein beta-1 (HSPB1 or HSP27) is the downstream mediator of this effect.
Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
Impact
GeneRIF
Timmerman et al., New York City, United States. In Nat Genet, 2004
missense mutation in the gene encoding 27-kDa small heat-shock protein B1 (HSPB1, also called HSP27) that segregates in a family with Charcot-Marie-Tooth disease
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
Impact
Saklatvala et al., Cambridge, United Kingdom. In Cell, 1994
An IL-1-stimulated protein kinase cascade resulting in phosphorylation of the small heat shock protein hsp27 has been identified in KB cells.
More papers using HSP27 antibodies
The PANTHER database of protein families, subfamilies, functions and pathways
Supplier
Weiss Robert H et al., In Molecular Cancer, 2004
... Goat polyclonal Hsp-27 and rabbit polyclonal phospho-Hsp27 antibodies were obtained from Santa Cruz Biotechnology and used at a 1:1000 ...
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
Supplier
Sugden Peter H. et al., In The Journal of Cell Biology, 1994
... The antibody to HSP25/27 (sc-1049) was from Santa Cruz Biotechnology Inc. ...
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