Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation.
Heidelberg, Germany. In Nature, Sep 2015
However, metazoans lack the key heat-shock protein disaggregase HSP100 of non-metazoan HSP70-dependent protein disaggregation systems, and the human HSP70 system alone, even with the crucial HSP110 nucleotide exchange factor, has poor disaggregation activity in vitro.
Microsatellite instability: an update.
Kawasaki, Japan. In Arch Toxicol, Jun 2015
Moreover, microsatellite repeats in miRNA genes, such as hsa-miR-1273c, may be novel MSI targets for CRC, and mutations in noncoding regulatory regions of MRE11, BAX (BaxΔ2), and HSP110 (HSP110ΔE9) may affect the efficiency of chemotherapy.
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Boston, United States. In Nature, 2014
Here we show in mice that whereas bone-marrow-derived CD1d signals contribute to NKT-cell-mediated intestinal inflammation, engagement of epithelial CD1d elicits protective effects through the activation of STAT3 and STAT3-dependent transcription of IL-10, heat shock protein 110 (HSP110; also known as HSP105), and CD1d itself.
Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer.
Seoul, South Korea. In World J Gastroenterol, 2014
Here, we have reviewed and discussed the molecular and prognostic features of MSI-H CRCs, as well as several putative prognostic or predictive molecular markers, including HSP110 expression, beta2-microglobulin mutations, myosin 1a expression, CDX2/CK20 expression, SMAD4 expression, CIMP status and LINE-1 methylation levels.