Mitochondrial dynamics and inherited peripheral nerve diseases.
Milano, Italy. In Neurosci Lett, Jul 2015
Abnormalities of mitochondrial dynamics produced by mutations in proteins involved in mitochondrial fusion (mitofusin-2, MFN2), fission (ganglioside-induced differentiation-associated protein-1, GDAP1), and mitochondrial axonal transport usually present with a Charcot-Marie-Tooth disease (CMT) phenotype.
Mitochondrial dynamics in pulmonary arterial hypertension.
Salt Lake City, United States. In J Mol Med (berl), Mar 2015
The molecular basis of this structural change includes upregulation and activation of fission mediators, notably dynamin-related protein 1 (DRP-1), and downregulation of fusion mediators, especially mitofusin-2 (MFN2).