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Heat shock transcription factor 2

HSF2, heat shock factor 2
The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: HSP70, CAN, ACID, Hsp90, HAD
Papers on HSF2
Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.
Thiele et al., Durham, United States. In Nat Struct Mol Biol, Feb 2016
We present crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA, revealing an unprecedented view of HSFs that provides insights into their unique biology.
Anti-inflammatory potential of β-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells.
Yang et al., Wuhan, China. In Reprod Toxicol, Jan 2016
In addition, CX significantly limited the LPS-induced down-regulation of AR, HSF2, CREB, FSHR, INHBB and ABP in Sertoli cells.
Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice.
Goto et al., Toyohashi, Japan. In Acta Physiol (oxf), Dec 2015
Neither type of mice exhibited much effect of heat stress on HSF mRNA expression (HSF1, HSF2 and HSF4).
Overexpression of a novel SbMYB15 from Salicornia brachiata confers salinity and dehydration tolerance by reduced oxidative damage and improved photosynthesis in transgenic tobacco.
Agarwal et al., Bhāvnagar, India. In Planta, Dec 2015
In the transgenic plants, the expression of stress-responsive genes such as LEA5, ERD10D, PLC3, LTP1, HSF2, ADC, P5CS, SOD and CAT was enhanced in the presence of salinity, dehydration and heat.
Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2.
Hayashida, Ube, Japan. In Biochem Biophys Res Commun, Dec 2015
Heat shock transcription factor 2 (HSF2) is one of four mammalian HSFs, and it is essential in neurogenesis and gametogenesis.
HSF2 autoregulates its own transcription.
Ahn et al., Kwangju, South Korea. In Int J Mol Med, Oct 2015
Heat shock factor 2 (HSF2) is one of the most important regulators affecting stress mechanisms, and is frequently amplified in the ubiquitin proteasome pathway.
The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144.
Liu et al., Shenyang, China. In Oncotarget, Sep 2015
Furthermore, Knockdown of TUG1 also down-regulated Heat shock transcription factor 2 (HSF2), a transcription factor of the heat shock transcription factor family, which was defined as a direct and functional downstream target of miR-144.
Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy.
Ahn et al., Seoul, South Korea. In Biochem Biophys Res Commun, Aug 2015
A previous study demonstrated that nuclear HSF1 and HSF2 molecules in live cells interacted with target DNAs on the stress granules.
Heat-shock factor 2 is a suppressor of prostate cancer invasion.
Nees et al., Turku, Finland. In Oncogene, Jul 2015
Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not been explored in malignancies.
Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approach.
Lau et al., Shantou, China. In J Proteome Res, 2012
Sumoylation of HSF2 on K82 regulates its DNA-binding ability, whereas sumoylation of HSF4B on K293 represses its transcriptional activity.
Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity.
Ahn et al., Kyŏngju, South Korea. In J Cell Physiol, 2012
our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a.
Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4.
Cohen et al., Stanford, United States. In Oncogene, 2011
HSF2 and HSF4 regulate transcription of HIF-1alpha and that a critical balance between these HSFs is required to maintain HIF-alpha expression in a repressed state.
HSFs and regulation of Hsp70.1 (Hspa1b) in oocytes and preimplantation embryos: new insights brought by transgenic and knockout mouse models.
Christians et al., Toulouse, France. In Cell Stress Chaperones, 2011
The roles of trans (HSF 1 and 2) and cis (HSE) regulatory elements in the control of Hsp70.1 (Hspa1b) through several developmental steps from oocytes to blastocysts, was investigated.
Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing cryptorchid-induced apoptosis in rat testes.
Huang et al., Beijing, China. In Mol Reprod Dev, 2011
The Hsf2 is mainly expressed in round spermatids in control testis. Hsf2 expression is significantly increased in both nuclei and cytoplasm of spermatocytes in 7-day cryptorchid testis.
miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis.
Sistonen et al., Turku, Finland. In Development, 2010
results reveal that miR-18 regulates HSF2 activity in spermatogenesis and link miR-18 to HSF2-mediated physiological processes such as male germ cell maturation.
The heat shock factor family and adaptation to proteotoxic stress.
Nakai et al., Ube, Japan. In Febs J, 2010
Furthermore, HSF2 and HSF4, as well as HSF1, shown to have roles in development, were also revealed to be necessary for the expression of certain nonclassical heat shock genes.
Heat shock factors at a crossroad between stress and development.
Sistonen et al., Turku, Finland. In Ann N Y Acad Sci, 2007
Mammals have three different HSFs that have been considered functionally distinct: HSF1 is essential for the heat shock response and is also required for developmental processes, whereas HSF2 and HSF4 are important for differentiation and development.
Heat shock response: lessons from mouse knockouts.
Benjamin et al., Toulouse, France. In Handb Exp Pharmacol, 2005
Yet Hsf2 knockouts by three independent laboratories have not fully clarified the role of mammalian HSF2 for normal development, fertility, and postnatal neuronal function.
Regulation of heat shock gene transcription in neuronal cells.
Calderwood et al., Boston, United States. In Int J Hyperthermia, 2005
HSF1 transcriptional activity has been discussed in neuronal cells, concentrating on the regulation and activity of HSF1 and HSF2 and their role in HSP expression, during neurodegenerative diseases and as mediators of cell survival.
Mechanism of hsp70i gene bookmarking.
Sarge et al., Lexington, United States. In Science, 2005
results show hsp70i bookmarking is mediated by HSF2 which binds this promoter in mitotic cells, recruits protein phosphatase 2A & interacts with the CAP-G subunit of condensin to promote dephosphorylation & inactivation of condensin complexes
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