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Heat shock 70kDa protein 8

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HSP70, Hsp90, CAN, ACID, HAD
Papers using HSC70 antibodies
Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.
Cai Huaibin, In PLoS ONE, 2009
... MA]; anti-Beclin 1 CAT# NBP1-45382 from Novus Biologicals, LLC [Littleton, CO]; anti-beta Synuclein CAT# ab25650 and anti-Hsc70 [N27F34] CAT# ab90347 from Abcam PLC [Cambridge, MA]; and ...
Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria
Eng Charis et al., In Human Molecular Genetics, 2005
... Antibodies used were α-PTEN monoclonal antibody clone 6H2.1 (Cascade Biosciences, Portland, OR, USA), α-Hsc70, α-tubulin and PARP-1 (Cell Signaling Technologies, Danvers, MA, USA) ...
Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation.
Rieux-Laucat Frederic, In PLoS ONE, 1999
... For Western blotting experiments, anti-GAPDH, anti-PI3K, anti-HSC70 were obtained from Santa Cruz Biotechnology (CA, USA), anti-phospho-Akt from ...
Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling
Katsoris Panagiotis et al., In Molecular Cancer, 1997
... Polyclonal antibodies against HSC70 were purchased from Santa Cruz Biotechnology, Inc ...
Papers on HSC70
Growth hormone transgenesis and polyploidy increase metabolic rate, alter the cardiorespiratory response and influence HSP expression in response to acute hypoxia in Atlantic salmon (Salmo salar) yolk-sac alevins.
Frappell et al., Hobart, Australia. In J Exp Biol, Aug 2014
Following hypoxia, the constitutive isoform of HSP70, HSC70, decreased in transgenics and HSP90 expression decreased in all genotypes.
Differential impacts of ocean acidification and warming on winter and summer progeny of a coastal squid (Loligo vulgaris).
Repolho et al., Cascais, Portugal. In J Exp Biol, Mar 2014
Concomitantly, there was a significant enhancement of the heat shock response (HSP70/HSC70) with warming in both pH treatments and developmental stages.
Comparative proteomics and expression analysis of five genes in Epicauta chinensis larvae from the first to fifth instar.
Zhang et al., China. In Plos One, Dec 2013
Among the five genes and their corresponding proteins' expression, only hsc70 gene showed a good correspondence with the protein level.
HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells.
Huang et al., Shanghai, China. In Plos One, Dec 2013
HSP40-PKM2 association destabilized PKM2 protein through HSC70.
Evidence for a Clathrin-independent mode of endocytosis at a continuously active sensory synapse.
Regus-Leidig et al., Erlangen, Germany. In Front Cell Neurosci, Dec 2013
These clusters labeled for Dynamin3, Endophilin1, and Synaptojanin1, but not for AP180, Clathrin LC, and hsc70.
Ultrasound targeted microbubble destruction for novel dual targeting of HSP72 and HSC70 in prostate cancer.
Du et al., Shanghai, China. In Asian Pac J Cancer Prev, Dec 2013
UTMD combined with dual targeting of HSP72 and HSC70 siRNA improve the efficiency of transfection, cell uptake of siRNA, downregulation of HSP70 and HSP90 expression in VCaP cells at the mRNA and protein level, and induction of extensive tumor-specific apoptosis.
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer.
Guan et al., Shanghai, China. In Cancer Cell, May 2013
Furthermore, the K5-acetylated LDH-A is recognized by the HSC70 chaperone and delivered to lysosomes for degradation.
Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential.
Cao et al., Saint Louis, United States. In Pharmacol Ther, 2012
Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone which belongs to the heat shock protein 70 (HSP70) family.
Integrated pathways of parkin control over mitochondrial maintenance - relevance to Parkinson's disease pathogenesis.
Zekanowski et al., Warsaw, Poland. In Acta Neurobiol Exp (wars), 2012
We discuss possible underlying molecular mechanisms, exerted by parkin in cooperation with other mitochondrial maintenance factors such as TFAM, PGC-1alpha, mortalin, HSP70/HSC70 and LRPPRC, all of them implicated in PD pathogenesis.
Matrine modulates HSC70 levels and rescues ΔF508-CFTR.
Mazzei et al., Salerno, Italy. In J Cell Physiol, 2012
downregulation of HSC70 resulted in increased levels of DeltaF508-CFTR complexes with the co-chaperone BAG3 that in addition appeared to co-localize with the mutated protein on the cell surface.
Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.
Luo et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
Hsc70 is a prerequisite for the surface translocation and angiogenic function of nucleolin, which suggests strategies to target both Hsc70 and NCL for more effective antiangiogenic therapies.
The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function.
Parker et al., Ithaca, United States. In J Virol, 2012
Hsc70 is recruited to reovirus viral factories independently of its chaperone function.
A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.
Shin et al., Seoul, South Korea. In J Am Chem Soc, 2012
It is proposed that Az suppresses ubiquitination of DeltaF508-CFTR maybe by blocking interaction of the mutant with Hsc70 and CHIP, and, as a consequence, it enhances membrane trafficking of the mutant
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Binder et al., Chicago, United States. In Biochemistry, 2011
Addition of Hsp70 to a mixture of oligomeric and fibrillar tau aggregates prevents the toxic effect of these tau species on fast axonal transport.
Molecular mechanism and physiological functions of clathrin-mediated endocytosis.
Boucrot et al., Cambridge, United Kingdom. In Nat Rev Mol Cell Biol, 2011
The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating.
The role of AUF1 in regulated mRNA decay.
Brewer et al., United States. In Wiley Interdiscip Rev Rna, 2010
These factors include translation initiation factor eIF4G, chaperones hsp27 and hsp70, heat-shock cognate protein hsc70, lactate dehydrogenase, poly(A)-binding protein, and other unidentified proteins.
Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.
Merchant et al., Nashville, United States. In Expert Rev Proteomics, 2010
Src family kinases, p53, mTOR and C-terminus of HSC70 interacting protein (CHIPs) are some examples associated with protein misfolding and tumorigenesis.
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.
Nukina et al., Wako, Japan. In Nat Biotechnol, 2010
As the polyglutamine binding peptide 1 (QBP1) is known to bind an expanded polyQ tract but not the polyQ motif found in normal HTT, we selectively targeted mutant HTT for degradation by expressing a fusion molecule comprising two copies of QBP1 and copies of two different heat shock cognate protein 70 (HSC70)-binding motifs in cellular and mouse models of HD.
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.
Workman et al., United Kingdom. In Cancer Cell, 2008
Simultaneously reducing the expression of both HSC70 and HSP72 induces proteasome-dependent degradation of HSP90 client proteins, G1 cell-cycle arrest, and extensive tumor-specific apoptosis in human tumor cell lines.
Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.
Blum et al., Indianapolis, United States. In Immunity, 2005
Manipulating APC expression of heat shock cognate protein 70 (hsc70), a cofactor for Lamp-2a, also altered cytoplasmic class II peptide presentation.
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