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Heat shock 70kDa protein 8

HSC70
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HSP70, Hsp90, CAN, ACID, HAD
Papers using HSC70 antibodies
Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure.
Supplier
Cai Huaibin, In PLoS ONE, 2009
... MA]; anti-Beclin 1 CAT# NBP1-45382 from Novus Biologicals, LLC [Littleton, CO]; anti-beta Synuclein CAT# ab25650 and anti-Hsc70 [N27F34] CAT# ab90347 from Abcam PLC [Cambridge, MA]; and ...
Structural and functional consequences of c-N-Ras constitutively associated with intact mitochondria
Supplier
Eng Charis et al., In Human Molecular Genetics, 2005
... Antibodies used were α-PTEN monoclonal antibody clone 6H2.1 (Cascade Biosciences, Portland, OR, USA), α-Hsc70, α-tubulin and PARP-1 (Cell Signaling Technologies, Danvers, MA, USA) ...
Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation.
Supplier
Rieux-Laucat Frederic, In PLoS ONE, 1999
... For Western blotting experiments, anti-GAPDH, anti-PI3K, anti-HSC70 were obtained from Santa Cruz Biotechnology (CA, USA), anti-phospho-Akt from ...
Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling
Supplier
Katsoris Panagiotis et al., In Molecular Cancer, 1997
... Polyclonal antibodies against HSC70 were purchased from Santa Cruz Biotechnology, Inc ...
Papers on HSC70
Grouper heat-shock cognate protein 70 (GHSC70) is involved in the cellular entry of nervous necrosis virus (NNV).
New
Chi et al., Taipei, Taiwan. In J Virol, 15 Nov 2014
To the best of our knowledge, this is the first report identifying grouper HSC70 and its role in NNV entry into GF-1 cells.
Regulation of FSP27 protein stability by AMPK and HSC70.
New
Liu et al., In Am J Physiol Endocrinol Metab, 14 Nov 2014
Furthermore, mass spectrometry-based proteomic analysis identified heat shock cognate 70 (HSC70) as a novel binding protein of FSP27.
Trehalose Improves Human Fibroblast Deficits in a New CHIP-Mutation Related Ataxia.
New
Mena et al., Madrid, Spain. In Plos One, Dec 2013
Recent studies have revealed that mutations in STUB-1 gene lead to a growing list of molecular defects as deregulation of protein quality, inhibition of proteasome, cell death, decreased autophagy and alteration in CHIP and HSP70 levels.
STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity.
New
Johansson et al., In Orphanet J Rare Dis, Dec 2013
We show that the p.Asn65Ser substitution impairs CHIP's ability to ubiquitinate HSC70 in vitro, despite being able to self-ubiquitinate.
The critical roles of HSC70 in physiological and pathological processes.
Review
New
Tang et al., Chongqing, China. In Curr Pharm Des, Dec 2013
The heat stress cognate 70 is one of the major cytoplasmic chaperones to supply a multitude of the housekeeping chaperoning functions.
HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.
Review
New
Muller et al., Strasbourg, France. In Autophagy, Dec 2013
HSPA8/HSC70 protein is a fascinating chaperone protein.
Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer.
New
Impact
Guan et al., Shanghai, China. In Cancer Cell, May 2013
Furthermore, the K5-acetylated LDH-A is recognized by the HSC70 chaperone and delivered to lysosomes for degradation.
Integrated pathways of parkin control over mitochondrial maintenance - relevance to Parkinson's disease pathogenesis.
Review
Zekanowski et al., Warsaw, Poland. In Acta Neurobiol Exp (wars), 2012
We discuss possible underlying molecular mechanisms, exerted by parkin in cooperation with other mitochondrial maintenance factors such as TFAM, PGC-1alpha, mortalin, HSP70/HSC70 and LRPPRC, all of them implicated in PD pathogenesis.
Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential.
Review
Cao et al., Saint Louis, United States. In Pharmacol Ther, 2012
Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone which belongs to the heat shock protein 70 (HSP70) family.
Matrine modulates HSC70 levels and rescues ΔF508-CFTR.
GeneRIF
Mazzei et al., Salerno, Italy. In J Cell Physiol, 2012
downregulation of HSC70 resulted in increased levels of DeltaF508-CFTR complexes with the co-chaperone BAG3 that in addition appeared to co-localize with the mutated protein on the cell surface.
Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.
GeneRIF
Luo et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
Hsc70 is a prerequisite for the surface translocation and angiogenic function of nucleolin, which suggests strategies to target both Hsc70 and NCL for more effective antiangiogenic therapies.
The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function.
GeneRIF
Parker et al., Ithaca, United States. In J Virol, 2012
Hsc70 is recruited to reovirus viral factories independently of its chaperone function.
A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.
GeneRIF
Shin et al., Seoul, South Korea. In J Am Chem Soc, 2012
It is proposed that Az suppresses ubiquitination of DeltaF508-CFTR maybe by blocking interaction of the mutant with Hsc70 and CHIP, and, as a consequence, it enhances membrane trafficking of the mutant
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
GeneRIF
Binder et al., Chicago, United States. In Biochemistry, 2011
Addition of Hsp70 to a mixture of oligomeric and fibrillar tau aggregates prevents the toxic effect of these tau species on fast axonal transport.
Molecular mechanism and physiological functions of clathrin-mediated endocytosis.
Review
Impact
Boucrot et al., Cambridge, United Kingdom. In Nat Rev Mol Cell Biol, 2011
The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating.
The role of AUF1 in regulated mRNA decay.
Review
Brewer et al., United States. In Wiley Interdiscip Rev Rna, 2010
These factors include translation initiation factor eIF4G, chaperones hsp27 and hsp70, heat-shock cognate protein hsc70, lactate dehydrogenase, poly(A)-binding protein, and other unidentified proteins.
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.
Impact
Nukina et al., Wako, Japan. In Nat Biotechnol, 2010
As the polyglutamine binding peptide 1 (QBP1) is known to bind an expanded polyQ tract but not the polyQ motif found in normal HTT, we selectively targeted mutant HTT for degradation by expressing a fusion molecule comprising two copies of QBP1 and copies of two different heat shock cognate protein 70 (HSC70)-binding motifs in cellular and mouse models of HD.
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.
Impact
GeneRIF
Workman et al., United Kingdom. In Cancer Cell, 2008
Simultaneously reducing the expression of both HSC70 and HSP72 induces proteasome-dependent degradation of HSP90 client proteins, G1 cell-cycle arrest, and extensive tumor-specific apoptosis in human tumor cell lines.
Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.
Impact
Blum et al., Indianapolis, United States. In Immunity, 2005
Manipulating APC expression of heat shock cognate protein 70 (hsc70), a cofactor for Lamp-2a, also altered cytoplasmic class II peptide presentation.
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