Proteomic analysis of exosomes derived from human lymphoma cells.
In Eur J Med Res, 01 Mar 2015
The data showed that some important proteins involved in antigen procession and presentation as well as cell migration and adhesion were also identified in EXORaji, such as MHC-I and II, HSC70, HSP90, and ICMA-1.ConclusionsLCEXs express a discrete set of proteins involved in antigen presentation and cell migration and adhesion, suggesting that LCEXs play an important role in the regulation of immunity and interaction between lymphoma cells and their microenvironment.
Matrine modulates HSC70 levels and rescues ΔF508-CFTR.
Salerno, Italy. In J Cell Physiol, 2012
downregulation of HSC70 resulted in increased levels of DeltaF508-CFTR complexes with the co-chaperone BAG3 that in addition appeared to co-localize with the mutated protein on the cell surface.
Molecular mechanism and physiological functions of clathrin-mediated endocytosis.
Cambridge, United Kingdom. In Nat Rev Mol Cell Biol, 2011
The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating.
The role of AUF1 in regulated mRNA decay.
United States. In Wiley Interdiscip Rev Rna, 2010
These factors include translation initiation factor eIF4G, chaperones hsp27 and hsp70, heat-shock cognate protein hsc70, lactate dehydrogenase, poly(A)-binding protein, and other unidentified proteins.
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.
Wako, Japan. In Nat Biotechnol, 2010
As the polyglutamine binding peptide 1 (QBP1) is known to bind an expanded polyQ tract but not the polyQ motif found in normal HTT, we selectively targeted mutant HTT for degradation by expressing a fusion molecule comprising two copies of QBP1 and copies of two different heat shock cognate protein 70 (HSC70)-binding motifs in cellular and mouse models of HD.