Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress.
Kuopio, Finland. In Redox Biol, 24 Nov 2014
We compared fish naturally living in a hot spring with relatively high water temperature (34.4±0.6°C) to those living in normal river water temperature (25.4±4.7°C), and found that levels of all the studied HSPs (HSP70, HSP60, HSP90, HSC70 and GRP75) were higher in fish living in elevated water temperature compared with normal river water temperature.
Matrine modulates HSC70 levels and rescues ΔF508-CFTR.
Salerno, Italy. In J Cell Physiol, 2012
downregulation of HSC70 resulted in increased levels of DeltaF508-CFTR complexes with the co-chaperone BAG3 that in addition appeared to co-localize with the mutated protein on the cell surface.
Molecular mechanism and physiological functions of clathrin-mediated endocytosis.
Cambridge, United Kingdom. In Nat Rev Mol Cell Biol, 2011
The process involves the formation of a putative FCH domain only (FCHO) initiation complex, which matures through adaptor protein 2 (AP2)-dependent cargo selection, and subsequent coat building, dynamin-mediated scission and finally auxilin- and heat shock cognate 70 (HSC70)-dependent uncoating.
The role of AUF1 in regulated mRNA decay.
United States. In Wiley Interdiscip Rev Rna, 2010
These factors include translation initiation factor eIF4G, chaperones hsp27 and hsp70, heat-shock cognate protein hsc70, lactate dehydrogenase, poly(A)-binding protein, and other unidentified proteins.
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein.
Wako, Japan. In Nat Biotechnol, 2010
As the polyglutamine binding peptide 1 (QBP1) is known to bind an expanded polyQ tract but not the polyQ motif found in normal HTT, we selectively targeted mutant HTT for degradation by expressing a fusion molecule comprising two copies of QBP1 and copies of two different heat shock cognate protein 70 (HSC70)-binding motifs in cellular and mouse models of HD.