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Spectrin, beta, erythrocytic

HS-2, EL3, SPTB
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009] (from NCBI)
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Top mentioned proteins: HPP, HAD, CAN, Beta-globin, ACID
Papers on HS-2
Optimized permeation enhancer for topical delivery of 5-fluorouracil-loaded elastic liposome using Design Expert: part II.
New
Ahmed et al., New Delhi, India. In Drug Deliv, Jan 2016
In vitro characterizations dictated the EL containing Span 80 (lipid:surfactant = 7:3) (EL3-S80) for further optimization of gel.
[Post-partum: Guidelines for clinical practice - Short text].
Review
New
Marpeau et al., Le Kremlin-Bicêtre, France. In J Gynecol Obstet Biol Reprod (paris), Dec 2015
In situations of proven psychological difficulties, the impact on the psycho-emotional development of children can be important (EL3).
[Impact of simulation to reduce neonatal and maternal morbidity of shoulder dystocia].
Review
New
Sentilhes et al., Angers, France. In J Gynecol Obstet Biol Reprod (paris), Dec 2015
Practical training using simulation for shoulder dystocia allows an improvement for manoeuvres mainly for trainees, but simulation seems to benefit to all caregivers for the communication (EL3).
[How to avoid the complications associated with hysterectomy: Place of subtotal hysterectomy, prevention of venous thromboembolism risk and preoperative treatment: Guidelines].
Review
New
Agostini et al., Marseille, France. In J Gynecol Obstet Biol Reprod (paris), Dec 2015
Subtotal hysterectomy is not associated with a decreased prevalence of intraoperative Hemorrhagic or visceral complications (EL3) or to a reduction in transfusions (EL2).
[Postpartum pelvic floor muscle training and abdominal rehabilitation: Guidelines].
Review
New
Thubert et al., Clamart, France. In J Gynecol Obstet Biol Reprod (paris), Dec 2015
Postpartum pelvic-floor rehabilitation in women presenting with anal incontinence, is associated with a lower prevalence of anal incontinence symptoms in short-term (1 year) (EL3) but not long-term (6 and 12) (EL3).
Comparison of the larvicidal efficacies of moxidectin or a five-day regimen of fenbendazole in horses harboring cyathostomin populations resistant to the adulticidal dosage of fenbendazole.
New
Nielsen et al., East Ridge, United States. In Vet Parasitol, Dec 2015
The five-day regimen of FBZ achieved 44.6% fecal egg count reduction, had 56.4% activity against luminal adults and larvae, and was 38.6% and 71.2% effective against encysted early third stage (EL3) and late third stage/ fourth stage (LL3/L4) cyathostomin larvae, respectively.
Altered erythrocyte membrane protein composition mirrors pleiotropic effects of hypertension susceptibility genes and disease pathogenesis.
New
Solodilova et al., Belgorod, Russia. In J Hypertens, Nov 2015
Regardless of sex, hypertensives exhibited mainly decreased levels of alpha (SPTA1) and beta-spectrin (SPTB) and increased levels of glucose transporter (GLUT1) as compared with healthy subjects (P ≤ 0.001).
CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth.
New
Hallman et al., Oulu, Finland. In J Immunol, Oct 2015
Spontaneous preterm birth (SPTB) is a major factor associating with deaths and with lowered quality of life in humans.
Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms.
New
Ilekis et al., Bethesda, United States. In Am J Obstet Gynecol, Sep 2015
OBJECTIVE: We sought to use an innovative tool that is based on common biologic pathways to identify specific phenotypes among women with spontaneous preterm birth (SPTB) to enhance investigators' ability to identify and to highlight common mechanisms and underlying genetic factors that are responsible for SPTB.
[A case-control study on association between OAS1 polymorphism and susceptibility to spontaneous preterm birth and preterm premature rupture of membranes].
New
Wang et al., Beijing, China. In Zhongguo Dang Dai Er Ke Za Zhi, Sep 2015
OBJECTIVE: To investigate the association between the genetic polymorphism of 2',5'-oligoadenylate synthetase 1 (OAS1) and susceptibility to spontaneous preterm birth (SPTB) and preterm premature rupture of membranes (PPROM).
The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth.
New
Jorde et al., Salt Lake City, United States. In Hum Genet, Jul 2015
The etiology of spontaneous PTB (SPTB) is complex and has an important genetic component.
Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor.
New
Tate et al., Montpellier, France. In Mol Pharmacol, Jun 2015
However, an extension in CGS21680 compared with adenosine, the (2-carboxyethyl)phenylethylamino group, binds in an extended vestibule formed from transmembrane regions 2 and 7 (TM2 and TM7) and extracellular loops 2 and 3 (EL2 and EL3).
Circulating serum-derived microparticles provide novel proteomic biomarkers of spontaneous preterm birth.
New
Sibai et al., Houston, United States. In Am J Perinatol, May 2015
OBJECTIVE: The purpose of this study was to determine whether the proteomic biosignature of circulating microparticles in maternal serum obtained in the second trimester could identify pregnancies that result in spontaneous preterm birth (SPTB).
[Definitions: small for gestational age and intrauterine growth retardation].
Review
Ego, Grenoble, France. In J Gynecol Obstet Biol Reprod (paris), 2013
Customized birth weight standards are based on an intrauterine growth modeling adjusted for fetal gender, maternal height, weight and parity, and appear to be the most accurate to identify SGA births at risk (EL3).
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
GeneRIF
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.
GeneRIF
Fung et al., Chicago, United States. In Protein Sci, 2011
Results suggest that it is possible for cellular proteins to differentially associate with the C-termini of different beta-spectrin isoforms to regulate alpha- and beta-spectrin association to form functional spectrin tetramers.
The actin binding domain of βI-spectrin regulates the morphological and functional dynamics of dendritic spines.
GeneRIF
Thompson et al., Baltimore, United States. In Plos One, 2010
suggest that betaI-spectrin is a synaptic protein that can modulate both the morphological and functional dynamics of dendritic spines, perhaps via interaction with actin and Rac3.
Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin.
GeneRIF
Sikorski et al., Wrocław, Poland. In Plos One, 2010
Data postulate that direct interactions between spectrin ankBDn and PE-rich domains play an important role in stabilizing the structure of the spectrin-based membrane skeleton.
Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.
GeneRIF
Mandal et al., Calcutta, India. In Plos One, 2010
analysis of glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis
A locus control region in the T cell receptor alpha/delta locus.
Impact
Winoto et al., Berkeley, United States. In Immunity, 1994
The transgene is expressed in the alpha beta but not the gamma delta T cell subset and is activated at the right time during development.
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