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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Hepatocyte growth factor-regulated tyrosine kinase substrate

HRs, HgS
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: HAD, CIs, AGE, iMpact, CAN
Papers using HRs antibodies
Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates
Supplier
Woodman Philip et al., In The Journal of Cell Biology, 2000
... Alternatively, Hrs was cloned into the vector pEGFP (CLONTECH Laboratories, Inc.) to generate ...
Papers on HRs
Circulating Metabolites and Survival Among Patients With Pancreatic Cancer.
New
Wolpin et al., Beijing, China. In J Natl Cancer Inst, Jun 2016
Participants in the highest vs lowest quintile had hazard ratios (HRs) for death of 1.89 (95% confidence interval [CI] = 1.06 to 3.35, P trend < .001)
Associations of Breast Cancer Risk Prediction Tools With Tumor Characteristics and Metastasis.
New
Impact
Czene et al., Stockholm, Sweden. In J Clin Oncol, Feb 2016
Cox proportional hazard models were used to estimate hazard ratios (HRs) of distant metastasis.
Impact of aldo-keto reductase family 1 member B10 on the risk of hepatitis C virus-related hepatocellular carcinoma.
New
Watanabe et al., Shizuoka, Japan. In J Gastroenterol Hepatol, Feb 2016
A multivariate Cox model was used to estimate the hazard ratios (HRs) of AKR1B10 expression for HCC development, and the cumulative incidence of HCC was evaluated using the Kaplan-Meier method.
Prognostic impact of carboxylesterase 1 gene variants in patients with congestive heart failure treated with angiotensin-converting enzyme inhibitors.
New
Hansen et al., Aalborg, Denmark. In Pharmacogenet Genomics, Feb 2016
After a mean follow-up of 5.5 years, we found no difference in the risk for cardiovascular death and all-cause death between patients having three [hazard ratios (HRs) 1.06 (95% confidence interval (CI) 0.77-1.45)
Do RA or TNF inhibitors increase the risk of cervical neoplasia or of recurrence of previous neoplasia? A nationwide study from Sweden.
New
ARTIS study group et al., Stockholm, Sweden. In Ann Rheum Dis, Feb 2016
HRs were assessed through Cox regressions adjusted for age, educational level, prior cervical screens, comorbidities, marital status and prior hospitalisations.
The Efficacy of Erlotinib Versus Conventional Chemotherapy for Advanced Nonsmall-Cell Lung Cancer: A PRISMA-Compliant Systematic Review With Meta-Regression and Meta-Analysis.
Review
New
Zhou et al., Zunyi, China. In Medicine (baltimore), Jan 2016
The HRs for PFS estimated based on 10 trials involving 1101 patients were 0.22 (95% CI = 0.15, 0.29) and 1.27 (95% CI = 1.04, 1.48) in EGFR mutation-type and wild-type patients, respectively.
Transgenic plants and hairy roots: exploiting the potential of plant species to remediate contaminants.
Review
New
Agostini et al., Río Cuarto, Argentina. In N Biotechnol, Jan 2016
In this context, hairy roots (HRs) have emerged as an interesting model system to explore the potential of plants to remove inorganic and organic pollutants.
Prognostic Value of SPARC in Patients with Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Review
New
Ding et al., Kunshan, China. In Plos One, Dec 2015
The pooled hazard ratios (HRs) and corresponding 95%CI of overall survival (OS) were calculated to evaluate the prognostic value of SPARC expression in patients with pancreatic cancer.
Potential Role of Circulating MiR-21 in the Diagnosis and Prognosis of Digestive System Cancer: A Systematic Review and Meta-Analysis.
Review
New
Zhang et al., Nanjing, China. In Medicine (baltimore), Dec 2015
For prognostic meta-analysis, pooled hazard ratios (HRs) of circulating miR-21 for survival were calculated.Totally 23 eligible publications were included in this meta-analysis (15 articles for diagnosis and 8 articles for prognosis).
Haemodynamic Responses to Selective Vagal Nerve Stimulation under Enalapril Medication in Rats.
New
Plachta et al., Freiburg, Germany. In Plos One, Dec 2015
After intravenous administration of enalapril (2 mg/kg bodyweight), the animals' mean arterial blood pressures (MAPs) decreased significantly, while the heart rates (HRs) were not significantly influenced.
Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
New
Impact
Cerhan et al., Bordeaux, France. In J Clin Oncol, Dec 2015
We calculated the hazard ratios (HRs) and 95% CIs for event-free survival (EFS) and overall survival (OS) using a log-additive genetic model with adjustment for age, sex, and age-adjusted International Prognostic Index.
Cherry-picked ligands at histamine receptor subtypes.
Review
New
Stark et al., Al `Ayn, United Arab Emirates. In Neuropharmacology, Dec 2015
Currently, the HRs have gained attention as important targets for the treatment of several diseases and disorders ranging from allergy to Alzheimer's disease and immune deficiency.
Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer.
New
Impact
Davidson et al., Boston, United States. In J Clin Oncol, Aug 2015
Results are expressed as hazard ratios (HRs) from Cox proportional hazards models.
Impact of Specific Epidermal Growth Factor Receptor (EGFR) Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer: A Meta-Analysis.
New
Impact
Yang et al., Sydney, Australia. In J Clin Oncol, Jul 2015
We calculated hazard ratios (HRs) and 95% CIs for PFS for the trial population and prespecified subgroups and calculated pooled estimates of treatment efficacy using the fixed-effects inverse-variance-weighted method.
Genomic analysis reveals that immune function genes are strongly linked to clinical outcome in the North Central Cancer Treatment Group n9831 Adjuvant Trastuzumab Trial.
New
Impact
Reinholz et al., Rochester, United States. In J Clin Oncol, Apr 2015
Cox proportional hazard ratios (HRs), adjusted for significant clinicopathologic risk factors, were used to determine the association of each gene with relapse-free survival (RFS) for 433 patients who received chemotherapy alone (arm A) and 849 patients who received chemotherapy plus trastuzumab (arms B and C).
Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.
GeneRIF
Clark et al., Fort Worth, United States. In Invest Ophthalmol Vis Sci, 2012
Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness.
Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway.
GeneRIF
Sugamura et al., Japan. In Virology, 2012
These results suggested that HCV secretion from host cells requires Hrs-dependent exosomal pathway in which the viral assembly is also involved.
Regulation of alternative splicing within the supraspliceosome.
GeneRIF
Sperling et al., Jerusalem, Israel. In J Struct Biol, 2012
We show that changes in alternative splicing of hnRNP A/B, affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes.
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo.
GeneRIF
Mishina et al., United States. In Dev Dyn, 2011
A new mechanism to modify BMP signaling by Hgs during early mouse development.
Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain.
GeneRIF
Gao et al., Beijing, China. In Protein Cell, 2011
Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
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