The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010] (from
Hansen et al., Aalborg, Denmark. In Pharmacogenet Genomics, Feb 2016
After a mean follow-up of 5.5 years, we found no difference in the risk for cardiovascular death and all-cause death between patients having three [hazard ratios (HRs) 1.06 (95% confidence interval (CI) 0.77-1.45)
Zhang et al., Nanjing, China. In Medicine (baltimore), Dec 2015
For prognostic meta-analysis, pooled hazard ratios (HRs) of circulating miR-21 for survival were calculated.Totally 23 eligible publications were included in this meta-analysis (15 articles for diagnosis and 8 articles for prognosis).
Plachta et al., Freiburg, Germany. In Plos One, Dec 2015
After intravenous administration of enalapril (2 mg/kg bodyweight), the animals' mean arterial blood pressures (MAPs) decreased significantly, while the heart rates (HRs) were not significantly influenced.
Cerhan et al., Bordeaux, France. In J Clin Oncol, Dec 2015
We calculated the hazard ratios (HRs) and 95% CIs for event-free survival (EFS) and overall survival (OS) using a log-additive genetic model with adjustment for age, sex, and age-adjusted International Prognostic Index.
Yang et al., Sydney, Australia. In J Clin Oncol, Jul 2015
We calculated hazard ratios (HRs) and 95% CIs for PFS for the trial population and prespecified subgroups and calculated pooled estimates of treatment efficacy using the fixed-effects inverse-variance-weighted method.
Reinholz et al., Rochester, United States. In J Clin Oncol, Apr 2015
Cox proportional hazard ratios (HRs), adjusted for significant clinicopathologic risk factors, were used to determine the association of each gene with relapse-free survival (RFS) for 433 patients who received chemotherapy alone (arm A) and 849 patients who received chemotherapy plus trastuzumab (arms B and C).