Hwang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2014
We previously identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistant biomarker in p53 wild-type A549 cells and found that p53-dependent induction of the PUMA pathway was a critical event in regulating the radioresistant phenotype.
Hwang et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2013
Here, we identified hepatoma-derived growth factor-related protein-3 (HRP-3) as a radioresistance-related gene and characterized the molecular mechanism by which its encoded protein regulates the radio- and chemoresistant phenotype of lung cancer-derived A549 cells.
Franken et al., Bonn, Germany. In J Neurosci Res, 2010
Antibody-mediated neutralization of HRP-3 function results in neuronal degeneration; this protein also exerts a neurite outgrowth-promoting effect when it is presented as a coated substrate but not as a soluble factor.
In particular, knockdown of 3 genes, encoding the hepatoma-derived growth factor related protein 3 (HDGFRP3), the frizzled homolog 2 (FZD2), and the dual specificity phosphatase 5 (DUSP5), induced proliferative arrest in Granta 519 MCL cells.
Haldar et al., Memphis, United States. In Biochim Biophys Acta, 2007
Previously, we have found that although the hrp3 mRNA is only seen in ring-stage parasites, deletion of a specific sequence in the 5' end of the promoter region decreased ring-stage expression of hrp3 and enabled detection of its transcripts in trophozoite-stage parasites.